KEGG   PATHWAY: hvi00480
Entry
hvi00480                    Pathway                                
Name
Glutathione metabolism - Homalodisca vitripennis (glassy-winged sharpshooter)
Class
Metabolism; Metabolism of other amino acids
Pathway map
hvi00480  Glutathione metabolism
hvi00480

Module
hvi_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:hvi00480]
Other DBs
GO: 0006749
Organism
Homalodisca vitripennis (glassy-winged sharpshooter) [GN:hvi]
Gene
124352810  glutathione hydrolase 7-like isoform X1 [KO:K00681] [EC:2.3.2.2 3.4.19.13]
124363018  scoloptoxin SSD14-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124363019  scoloptoxin SSD14-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124363665  scoloptoxin SSD14-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124367297  scoloptoxin SSD14-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124367589  scoloptoxin SSD14-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124367591  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
124370945  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
124355419  gamma-glutamylcyclotransferase-like [KO:K00682] [EC:4.3.2.9]
124360093  glutathione-specific gamma-glutamylcyclotransferase 1 [KO:K07232] [EC:4.3.2.7]
124360539  putative glutathione-specific gamma-glutamylcyclotransferase 2 [KO:K07232] [EC:4.3.2.7]
124360680  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
124359551  glutamate--cysteine ligase [KO:K11204] [EC:6.3.2.2]
124368977  glutamate--cysteine ligase regulatory subunit isoform X1 [KO:K11205]
124361924  glutathione synthetase-like isoform X1 [KO:K21456] [EC:6.3.2.3]
124357898  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124359529  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124371234  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124363343  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124363384  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124357216  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124357392  cytosol aminopeptidase-like [KO:K11142] [EC:3.4.11.1 3.4.11.5]
124359054  putative aminopeptidase W07G4.4 isoform X1 [KO:K01255] [EC:3.4.11.1]
124359119  putative aminopeptidase W07G4.4 isoform X1 [KO:K01255] [EC:3.4.11.1]
124368503  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
124368927  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
124368967  membrane alanyl aminopeptidase-like [KO:K11140] [EC:3.4.11.2]
124369267  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
124369648  LOW QUALITY PROTEIN: aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
124369649  aminopeptidase N-like [KO:K11140] [EC:3.4.11.2]
124369772  glutamyl aminopeptidase-like isoform X1 [KO:K11140] [EC:3.4.11.2]
124370045  aminopeptidase N [KO:K11140] [EC:3.4.11.2]
124360785  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
124373970  aminopeptidase Ey-like [KO:K11140] [EC:3.4.11.2]
124354488  aminopeptidase N-like isoform X1 [KO:K11140] [EC:3.4.11.2]
124357962  glutathione S-transferase D5-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124368352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124358654  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124369242  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124371224  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361800  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361941  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124361943  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361944  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361945  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124373887  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124363353  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124353840  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
124366181  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124355869  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
124356706  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367172  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124367503  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
124367723  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367830  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367831  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367832  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367833  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367834  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124359197  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359713  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359714  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124372366  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373429  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373430  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124374570  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124355503  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366172  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366173  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366369  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366374  glutathione S-transferase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366381  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366382  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366747  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366896  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367539  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367541  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367542  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367544  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359571  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
124361822  isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
124359513  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
124368871  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
124355379  thioredoxin domain-containing protein 12-like [KO:K05360] [EC:1.8.4.2]
124372272  LOW QUALITY PROTEIN: probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
124373253  putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
124365921  LOW QUALITY PROTEIN: glutathione peroxidase-like [KO:K00432] [EC:1.11.1.9]
124355212  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
124355214  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
124364960  peroxiredoxin-6 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
124370452  pyrimidodiazepine synthase-like [KO:K00310] [EC:1.5.4.1]
124371540  pyrimidodiazepine synthase-like [KO:K00310] [EC:1.5.4.1]
124368768  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
124362953  spermidine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
124356724  spermine synthase-like isoform X1 [KO:K00802] [EC:2.5.1.22]
124356725  spermine synthase-like [KO:K00802] [EC:2.5.1.22]
124356673  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
124353678  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
hvi00220  Arginine biosynthesis
hvi00250  Alanine, aspartate and glutamate metabolism
hvi00270  Cysteine and methionine metabolism
hvi00430  Taurine and hypotaurine metabolism
KO pathway
ko00480   
LinkDB

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