KEGG   PATHWAY: jre04148
Entry
jre04148                    Pathway                                
Name
Efferocytosis - Juglans regia (English walnut)
Class
Cellular Processes; Transport and catabolism
Pathway map
jre04148  Efferocytosis
jre04148

Organism
Juglans regia (English walnut) [GN:jre]
Gene
109013735  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
109022242  mitogen-activated protein kinase homolog NTF6-like [KO:K04371] [EC:2.7.11.24]
109018692  mitogen-activated protein kinase kinase 6 [KO:K04368] [EC:2.7.12.2]
109002837  mitogen-activated protein kinase kinase 6-like [KO:K04368] [EC:2.7.12.2]
109009749  uncharacterized protein LOC109009749 [KO:K17398] [EC:2.1.1.37]
109007860  calcium-transporting ATPase 3, endoplasmic reticulum-type isoform X1 [KO:K05853] [EC:7.2.2.10]
109022280  protein-tyrosine-phosphatase IBR5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
109012657  protein-tyrosine-phosphatase IBR5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108983764  phospholipid-transporting ATPase 1 [KO:K14802] [EC:7.6.2.1]
108990001  phospholipid-transporting ATPase 1-like isoform X1 [KO:K14802] [EC:7.6.2.1]
108989806  phospholipid-transporting ATPase 3 [KO:K14802] [EC:7.6.2.1]
109009997  phospholipid-transporting ATPase 1-like [KO:K14802] [EC:7.6.2.1]
108990278  putative ALA-interacting subunit 2 [KO:K26935]
109010089  ALA-interacting subunit 1-like [KO:K26935]
108998976  ALA-interacting subunit 3 [KO:K26935]
108987936  ALA-interacting subunit 1-like [KO:K26935]
109000924  rac-like GTP-binding protein RAC13 [KO:K04392]
109010441  rac-like GTP-binding protein 5 [KO:K04392]
108991182  rac-like GTP-binding protein ARAC8 isoform X1 [KO:K04392]
108986802  rac-like GTP-binding protein ARAC7 [KO:K04392]
108990452  rac-like GTP-binding protein RAC2 [KO:K04392]
108981276  rac-like GTP-binding protein ARAC7 [KO:K04392]
108997691  rac-like GTP-binding protein ARAC1 isoform X2 [KO:K04392]
108993869  rac-like GTP-binding protein RAC2 [KO:K04392]
108993439  rac-like GTP-binding protein RAC1 [KO:K04392]
109020817  rac-like GTP-binding protein RHO1 [KO:K04392]
109004408  rac-like GTP-binding protein RAC13 isoform X1 [KO:K04392]
109006599  rac-like GTP-binding protein RAC1 [KO:K04392]
109011240  rac-like GTP-binding protein RHO1 [KO:K04392]
108993648  rac-like GTP-binding protein RAC2 [KO:K04392]
108999100  rac-like GTP-binding protein 3 isoform X1 [KO:K04392]
108985082  calreticulin-3-like isoform X1 [KO:K08057]
108987726  calreticulin [KO:K08057]
108997258  calreticulin-3-like isoform X1 [KO:K08057]
109019075  calreticulin-like [KO:K08057]
108988146  ras-related protein Rab5 [KO:K07889]
109006111  ras-related protein RHN1-like isoform X1 [KO:K07889]
108979382  ras-related protein RHN1-like isoform X1 [KO:K07889]
109004658  ras-related protein RHN1-like isoform X1 [KO:K07889]
118343641  ras-related protein RHN1-like isoform X1 [KO:K07889]
109006449  vacuolar sorting protein 3 [KO:K20177]
108992639  vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
108984271  vacuolar protein-sorting-associated protein 11 homolog [KO:K20179]
108994650  protein VACUOLELESS1 [KO:K20180]
108984575  vacuolar sorting protein 18 isoform X1 [KO:K20181]
108992757  vacuolar protein-sorting-associated protein 33 homolog [KO:K20182]
108995337  vacuolar sorting protein 39 [KO:K20183]
109001078  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
109000658  vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
108981172  ras-related protein Rab7 [KO:K07897]
108988685  ras-related protein Rab7-like [KO:K07897]
108989111  ras-related protein Rab7-like isoform X1 [KO:K07897]
108979369  ras-related protein Rab7-like [KO:K07897]
108983544  ras-related protein Rab7-like [KO:K07897]
109003704  ras-related protein Rab7-like [KO:K07897]
109011197  ras-related protein Rab7 [KO:K07897]
109012251  ras-related protein Rab7 [KO:K07897]
108997502  probable vacuolar amino acid transporter YPQ1 isoform X1 [KO:K23678]
109008117  uncharacterized protein LOC109008117 [KO:K23678]
108995386  probable vacuolar amino acid transporter YPQ1 [KO:K23678]
109007360  arginase 1, mitochondrial [KO:K01476] [EC:3.5.3.1]
108981013  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109001852  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like isoform X1 [KO:K00411] [EC:7.1.1.8]
109006497  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
109001287  cytochrome b-c1 complex subunit Rieske-4, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
108992070  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
108996328  triacylglycerol lipase 1 [KO:K01052] [EC:3.1.1.13]
109006067  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
108995819  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
108995835  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
108998231  triacylglycerol lipase 2-like [KO:K01052] [EC:3.1.1.13]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
jre00010  Glycolysis / Gluconeogenesis
jre04145  Phagosome
KO pathway
ko04148   
LinkDB

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