KEGG   PATHWAY: kaf00260
Entry
kaf00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Kazachstania africana
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kaf00260  Glycine, serine and threonine metabolism
kaf00260

Module
kaf_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kaf00260]
kaf_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kaf00260]
kaf_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kaf00260]
kaf_M00621  Glycine cleavage system [PATH:kaf00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Kazachstania africana [GN:kaf]
Gene
KAFR_0L00780  KAFR0L00780; hypothetical protein [KO:K00928] [EC:2.7.2.4]
KAFR_0B05830  KAFR0B05830; hypothetical protein [KO:K00133] [EC:1.2.1.11]
KAFR_0B06920  KAFR0B06920; hypothetical protein [KO:K00003] [EC:1.1.1.3]
KAFR_0E01770  KAFR0E01770; hypothetical protein [KO:K00872] [EC:2.7.1.39]
KAFR_0J02530  KAFR0J02530; hypothetical protein [KO:K01733] [EC:4.2.3.1]
KAFR_0E00450  KAFR0E00450; hypothetical protein [KO:K01620] [EC:4.1.2.48]
KAFR_0D00990  KAFR0D00990; hypothetical protein [KO:K00600] [EC:2.1.2.1]
KAFR_0C03490  KAFR0C03490; hypothetical protein [KO:K00600] [EC:2.1.2.1]
KAFR_0C04320  KAFR0C04320; hypothetical protein [KO:K00600] [EC:2.1.2.1]
KAFR_0C03500  KAFR0C03500; hypothetical protein [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
KAFR_0C00970  KAFR0C00970; hypothetical protein [KO:K01834] [EC:5.4.2.11]
KAFR_0E01720  KAFR0E01720; hypothetical protein [KO:K01834] [EC:5.4.2.11]
KAFR_0B04030  KAFR0B04030; hypothetical protein [KO:K15918] [EC:2.7.1.31]
KAFR_0B01270  KAFR0B01270; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KAFR_0L01110  KAFR0L01110; hypothetical protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KAFR_0G02400  KAFR0G02400; hypothetical protein [KO:K00831] [EC:2.6.1.52]
KAFR_0B04060  KAFR0B04060; hypothetical protein [KO:K01079] [EC:3.1.3.3]
KAFR_0B03360  KAFR0B03360; hypothetical protein [KO:K16066] [EC:1.1.1.381 1.1.1.-]
KAFR_0E02710  KAFR0E02710; hypothetical protein [KO:K00643] [EC:2.3.1.37]
KAFR_0A07180  KAFR0A07180; hypothetical protein [KO:K00281] [EC:1.4.4.2]
KAFR_0E01140  KAFR0E01140; hypothetical protein [KO:K00605] [EC:2.1.2.10]
KAFR_0D01070  KAFR0D01070; hypothetical protein [KO:K00382] [EC:1.8.1.4]
KAFR_0K00450  KAFR0K00450; hypothetical protein [KO:K02437]
KAFR_0F04100  KAFR0F04100; hypothetical protein [KO:K17103] [EC:2.7.8.8]
KAFR_0I01230  KAFR0I01230; hypothetical protein [KO:K01697] [EC:4.2.1.22]
KAFR_0K00760  KAFR0K00760; hypothetical protein [KO:K01758] [EC:4.4.1.1]
KAFR_0K01700  KAFR0K01700; hypothetical protein [KO:K01754] [EC:4.3.1.19]
KAFR_0I00130  KAFR0I00130; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KAFR_0F04430  KAFR0F04430; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KAFR_0D00110  KAFR0D00110; hypothetical protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KAFR_0I00990  KAFR0I00990; hypothetical protein [KO:K01694] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kaf00010  Glycolysis / Gluconeogenesis
kaf00020  Citrate cycle (TCA cycle)
kaf00230  Purine metabolism
kaf00250  Alanine, aspartate and glutamate metabolism
kaf00270  Cysteine and methionine metabolism
kaf00290  Valine, leucine and isoleucine biosynthesis
kaf00300  Lysine biosynthesis
kaf00330  Arginine and proline metabolism
kaf00460  Cyanoamino acid metabolism
kaf00564  Glycerophospholipid metabolism
kaf00600  Sphingolipid metabolism
kaf00620  Pyruvate metabolism
kaf00630  Glyoxylate and dicarboxylate metabolism
kaf00640  Propanoate metabolism
kaf00680  Methane metabolism
kaf00860  Porphyrin metabolism
kaf00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system