KEGG   PATHWAY: lang00480
Entry
lang00480                   Pathway                                
Name
Glutathione metabolism - Lupinus angustifolius (narrow-leaved blue lupine)
Class
Metabolism; Metabolism of other amino acids
Pathway map
lang00480  Glutathione metabolism
lang00480

Module
lang_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:lang00480]
Other DBs
GO: 0006749
Organism
Lupinus angustifolius (narrow-leaved blue lupine) [GN:lang]
Gene
109357607  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109357608  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109351088  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109328195  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
109344182  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
109359215  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
109326518  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
109327376  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
109349277  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
109333351  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
109349964  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
109331368  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
109345789  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
109330278  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
109326907  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
109339545  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
109346442  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
109355021  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
109332852  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
109349949  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
109363329  glutathione S-transferase U19-like [KO:K00799] [EC:2.5.1.18]
109331969  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109346124  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109336433  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
109345909  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
109351973  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109351974  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
109338280  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109338283  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109342454  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
109341645  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109339124  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
109359360  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
109359364  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
109361674  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109362768  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109325832  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
109347164  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109345150  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
109339540  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109339548  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109342046  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
109327858  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
109361107  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109344899  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
109344900  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
109348042  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109348043  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109348044  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109348045  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109352610  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109352611  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109352612  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109354884  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
109361836  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
109359195  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109329084  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
109328464  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109328465  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109348406  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
109347569  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
109332763  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
109349259  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
109350063  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
109360653  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109339387  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
109339393  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
109339395  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109360477  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
109335897  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109345126  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109354486  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109359087  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
109361339  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
109340532  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
109340536  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
109360825  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
109346674  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
109335306  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109361040  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109339606  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109333594  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109357486  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
109354670  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109338455  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
109354233  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109349932  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109330303  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109331614  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
109354773  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109356564  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109336332  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109358315  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109341762  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109330040  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109345846  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109354538  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
109348485  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
109334698  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
109332749  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109340865  phospholipid hydroperoxide glutathione peroxidase, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
109349727  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109349979  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109349982  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
109330497  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
109336860  phospholipid hydroperoxide glutathione peroxidase, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
109362119  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
109343986  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109327937  LDC; ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
109327164  spermine synthase [KO:K00797] [EC:2.5.1.16]
109333444  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
109344937  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
109330471  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
109362692  spermidine synthase-like [KO:K00797] [EC:2.5.1.16]
109349203  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
109363606  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
109348741  probable L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
109328226  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
109351626  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
109328584  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
109355353  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
109325078  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
109332963  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109343738  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
109353210  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109344314  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
109355503  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
109361590  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
109360372  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
109337653  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
109338955  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
109360242  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
109356696  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
lang00220  Arginine biosynthesis
lang00250  Alanine, aspartate and glutamate metabolism
lang00270  Cysteine and methionine metabolism
lang00430  Taurine and hypotaurine metabolism
lang00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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