KEGG   PATHWAY: leif00030
Entry
leif00030                   Pathway                                
Name
Pentose phosphate pathway - Leifsonia sp. PS1209
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
leif00030  Pentose phosphate pathway
leif00030

Module
leif_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:leif00030]
leif_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:leif00030]
leif_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:leif00030]
leif_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:leif00030]
leif_M00061  D-Glucuronate degradation, D-glucuronate => pyruvate + D-glyceraldehyde 3P [PATH:leif00030]
Other DBs
GO: 0006098
Organism
Leifsonia sp. PS1209 [GN:leif]
Gene
HF024_10350  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
HF024_07960  glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
HF024_10355  glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
HF024_10365  pgl; 6-phosphogluconolactonase [KO:K01057] [EC:3.1.1.31]
HF024_00860  lactonase family protein [KO:K07404] [EC:3.1.1.31]
HF024_00015  gnd; decarboxylating 6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
HF024_12840  gndA; NADP-dependent phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
HF024_10725  rpe; ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
HF024_10340  transketolase [KO:K00615] [EC:2.2.1.1]
HF024_10345  tal; transaldolase [KO:K00616] [EC:2.2.1.2]
HF024_07190  ribose-5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
HF024_08990  ribose-5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
HF024_10565  phosphoketolase family protein [KO:K01621] [EC:4.1.2.9 4.1.2.22]
HF024_02595  deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
HF024_06960  deoC; deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
HF024_02570  ribokinase [KO:K00852] [EC:2.7.1.15]
HF024_13315  ribokinase [KO:K00852] [EC:2.7.1.15]
HF024_17010  ribokinase [KO:K00852] [EC:2.7.1.15]
HF024_01530  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
HF024_12850  ribose-phosphate diphosphokinase [KO:K00948] [EC:2.7.6.1]
HF024_00790  bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
HF024_04310  glucose 1-dehydrogenase [KO:K00034] [EC:1.1.1.47]
HF024_04025  gluconate 2-dehydrogenase subunit 3 family protein [KO:K06152] [EC:1.1.99.3]
HF024_02150  gluconokinase [KO:K00851] [EC:2.7.1.12]
HF024_00780  sugar kinase [KO:K00874] [EC:2.7.1.45]
HF024_12505  fbaA; class II fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
HF024_14300  class II fructose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
HF024_12500  glpX; class II fructose-bisphosphatase [KO:K02446] [EC:3.1.3.11]
HF024_07035  6-phosphofructokinase [KO:K21071] [EC:2.7.1.11 2.7.1.90]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
leif00010  Glycolysis / Gluconeogenesis
leif00040  Pentose and glucuronate interconversions
leif00052  Galactose metabolism
leif00230  Purine metabolism
leif00240  Pyrimidine metabolism
leif00340  Histidine metabolism
leif00630  Glyoxylate and dicarboxylate metabolism
leif00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

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