KEGG   PATHWAY: lper00020
Entry
lper00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Lolium perenne (perennial ryegrass)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
lper00020  Citrate cycle (TCA cycle)
lper00020

Module
lper_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:lper00020]
lper_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:lper00020]
lper_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:lper00020]
lper_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:lper00020]
lper_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:lper00020]
Other DBs
GO: 0006099
Organism
Lolium perenne (perennial ryegrass) [GN:lper]
Gene
127320773  citrate synthase, glyoxysomal-like [KO:K01647] [EC:2.3.3.1]
127307561  citrate synthase 4, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
127294597  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
127299229  ATP-citrate synthase alpha chain protein 3 isoform X1 [KO:K01648] [EC:2.3.3.8]
127342615  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
127314620  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
127325714  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
127335528  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
127342214  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
127343151  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
127335267  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
127323162  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
127307326  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
127331311  uncharacterized protein LOC127331311 [KO:K00164] [EC:1.2.4.2]
127334300  uncharacterized protein LOC127334300 [KO:K00164] [EC:1.2.4.2]
127293788  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
127331040  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
127326972  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
127327076  dihydrolipoyl dehydrogenase 1, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
127291795  dihydrolipoyl dehydrogenase 2, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
127292417  dihydrolipoyl dehydrogenase 1, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
127332909  succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
127307067  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
127333967  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
127292611  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like isoform X1 [KO:K00234] [EC:1.3.5.1]
127314355  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
127298094  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial [KO:K00235] [EC:1.3.5.1]
127333291  succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236]
127333663  succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236]
127316842  succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801]
127345580  succinate dehydrogenase subunit 4, mitochondrial-like isoform X1 [KO:K25801]
127295475  uncharacterized protein LOC127295475 isoform X1 [KO:K01679] [EC:4.2.1.2]
127331567  fumarate hydratase 1, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
127335844  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
127300519  malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
127343139  malate dehydrogenase 1, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
127301695  malate dehydrogenase, chloroplastic [KO:K00026] [EC:1.1.1.37]
127326333  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
127327740  malate dehydrogenase 1, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
127292626  malate dehydrogenase, glyoxysomal-like [KO:K00026] [EC:1.1.1.37]
127296191  phosphoenolpyruvate carboxykinase (ATP)-like [KO:K01610] [EC:4.1.1.49]
127317433  pyruvate dehydrogenase E1 component subunit alpha-2, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
127305129  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
127306173  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial [KO:K00161] [EC:1.2.4.1]
127330898  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like [KO:K00161] [EC:1.2.4.1]
127293695  pyruvate dehydrogenase E1 component subunit beta-4, chloroplastic [KO:K00162] [EC:1.2.4.1]
127316572  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
127298548  pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like [KO:K00162] [EC:1.2.4.1]
127302354  pyruvate dehydrogenase E1 component subunit beta-2, mitochondrial [KO:K00162] [EC:1.2.4.1]
127311683  dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627] [EC:2.3.1.12]
127314779  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
127299644  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
127301325  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
127301735  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627] [EC:2.3.1.12]
127308977  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
lper00010  Glycolysis / Gluconeogenesis
lper00053  Ascorbate and aldarate metabolism
lper00061  Fatty acid biosynthesis
lper00062  Fatty acid elongation
lper00071  Fatty acid degradation
lper00190  Oxidative phosphorylation
lper00220  Arginine biosynthesis
lper00250  Alanine, aspartate and glutamate metabolism
lper00280  Valine, leucine and isoleucine degradation
lper00350  Tyrosine metabolism
lper00470  D-Amino acid metabolism
lper00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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