KEGG   PATHWAY: lsq03013
Entry
lsq03013                    Pathway                                
Name
Nucleocytoplasmic transport - Lucilia sericata (common green bottle fly)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
lsq03013  Nucleocytoplasmic transport
lsq03013

Other DBs
GO: 0050658
Organism
Lucilia sericata (common green bottle fly) [GN:lsq]
Gene
119614191  aladin [KO:K14320]
119606811  nucleoporin NUP116/NSP116-like [KO:K14321]
119607638  nucleoporin Gle1 [KO:K18723]
119601473  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
119608015  mRNA export factor [KO:K14298]
119601669  nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
119609880  nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
119601379  nuclear pore complex protein Nup88 [KO:K14318]
119611151  E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
119611876  ran GTPase-activating protein [KO:K14319]
119609153  SUMO-conjugating enzyme UBC9-B [KO:K10577]
119607348  small ubiquitin-related modifier 3 [KO:K12160]
119599944  nuclear pore complex protein Nup160 homolog [KO:K14303]
119600685  nuclear pore complex protein Nup75 [KO:K14304]
119602659  protein SEC13 homolog [KO:K14004]
119606022  nuclear pore complex protein Nup107 [KO:K14301]
119609852  nuclear pore complex protein Nup133 [KO:K14300]
119615273  nucleoporin seh1 [KO:K14299]
119616116  nucleoporin seh1 [KO:K14299]
119607164  nucleoporin Nup43 [KO:K14305]
119603907  nucleoporin Nup37 [KO:K14302]
119601411  protein ELYS homolog [KO:K25129]
119603561  nuclear pore glycoprotein p62 [KO:K14306]
119613325  nuclear pore complex protein Nup58 [KO:K14307]
119606383  probable nucleoporin Nup54 isoform X1 [KO:K14308]
119603035  nuclear pore complex protein Nup205 [KO:K14310]
119603966  nucleoporin NUP188 homolog [KO:K14311]
119605425  nuclear pore complex protein Nup154 [KO:K14312]
119602239  nuclear pore complex protein Nup93-1-like [KO:K14309]
119599666  nucleoporin Nup35 isoform X1 [KO:K14313]
119604237  nucleoporin Ndc1 [KO:K14315]
119612977  nuclear pore membrane glycoprotein 210 [KO:K14314]
119604886  nuclear pore complex protein DDB_G0274915 [KO:K14316]
119604069  Krueppel homolog 2 [KO:K20724]
119616144  nucleoprotein TPR [KO:K09291]
119602009  nuclear pore complex protein Nup50 [KO:K14295]
119603161  nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
119606487  LOW QUALITY PROTEIN: importin subunit alpha [KO:K15043]
119600510  importin subunit alpha-3 [KO:K23583]
119603239  LOW QUALITY PROTEIN: importin subunit alpha-5 [KO:K15042]
119611800  importin subunit beta [KO:K14293]
119610383  transportin-1-like [KO:K18752]
119599741  transportin-3 [KO:K15436]
119608823  importin-4 [KO:K20221]
119604205  importin-5 [KO:K20222]
119607966  importin-7 [KO:K20223]
119599537  importin-11 [KO:K25201]
119600340  importin-13 [KO:K25202]
119600393  snurportin-1 [KO:K13151]
119600395  uncharacterized protein LOC119600395 isoform X1 [KO:K13151]
119616474  exportin-1 [KO:K14290]
119610930  exportin-2 [KO:K18423]
119601394  exportin-5 [KO:K14289]
119599949  exportin-6 [KO:K25204]
119603595  ran-binding protein 16 [KO:K18460]
119612287  GTP-binding nuclear protein Ran [KO:K07936]
119614804  elongation factor 1-alpha 2 [KO:K03231]
119605497  elongation factor 1-alpha 1 [KO:K03231]
119606044  phosphorylated adapter RNA export protein [KO:K14291]
119607878  nuclear cap-binding protein subunit 1 [KO:K12882]
119600333  nuclear cap-binding protein subunit 2 [KO:K12883]
119604846  60S ribosomal export protein NMD3 [KO:K07562]
119604852  60S ribosomal export protein NMD3-like [KO:K07562]
119606040  RNA-binding protein 8A [KO:K12876]
119614971  protein mago nashi [KO:K12877]
119614974  protein mago nashi [KO:K12877]
119614980  protein mago nashi [KO:K12877]
119615085  protein mago nashi [KO:K12877]
119609616  protein mago nashi [KO:K12877]
119600896  putative uncharacterized protein DDB_G0271606 [KO:K14323]
119601568  putative uncharacterized protein DDB_G0271606 [KO:K14323]
119610510  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119610512  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
119606720  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
119604847  histone deacetylase complex subunit SAP18 [KO:K14324]
119600344  RNA-binding protein with serine-rich domain 1 [KO:K14325]
119600540  THO complex subunit 4 isoform X1 [KO:K12881]
119606047  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
119601022  regulator of nonsense transcripts 2 [KO:K14327]
119614907  LOW QUALITY PROTEIN: regulator of nonsense transcripts 3B-like [KO:K14328]
119613051  LOW QUALITY PROTEIN: regulator of nonsense transcripts 3B-like [KO:K14328]
119606555  LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
119609910  NTF2-related export protein [KO:K14285]
119600406  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
119608511  serine/arginine repetitive matrix protein 1 [KO:K13171]
119605777  partner of Y14 and mago [KO:K14294]
119615962  THO complex subunit 1 [KO:K12878]
119600602  THO complex subunit 5 [KO:K13174]
119610047  THO complex subunit 6 [KO:K13175]
119606454  THO complex protein 7 isoform X1 [KO:K13176]
119606593  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
lsq03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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