KEGG   PATHWAY: mcx00630
Entry
mcx00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium canettii CIPT 140070010
Class
Metabolism; Carbohydrate metabolism
Pathway map
mcx00630  Glyoxylate and dicarboxylate metabolism
mcx00630

Module
mcx_M00012  Glyoxylate cycle [PATH:mcx00630]
mcx_M00621  Glycine cleavage system [PATH:mcx00630]
mcx_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mcx00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium canettii CIPT 140070010 [GN:mcx]
Gene
BN42_20191  icl; Isocitrate lyase Icl (isocitrase) (isocitratase) [KO:K01637] [EC:4.1.3.1]
BN42_30208  aceA; Isocitrate lyase [KO:K01637] [EC:4.1.3.1]
BN42_90179  acs; Acetyl-CoA synthetase Acs (Acetate CoA ligase) [KO:K01895] [EC:6.2.1.1]
BN42_30099  glcB; Malate synthase G GlcB [KO:K01638] [EC:2.3.3.9]
BN42_21113  mdh; Putative malate dehydrogenase Mdh [KO:K00024] [EC:1.1.1.37]
BN42_20675  citA; Putative citrate synthase II CitA [KO:K01647] [EC:2.3.3.1]
BN42_20681  gltA; Putative citrate synthase I GltA2 [KO:K01647] [EC:2.3.3.1]
BN42_20984  gltA; Putative citrate synthase I GltA I [KO:K01647] [EC:2.3.3.1]
BN42_21399  acnA; Aconitate hydratase 1 [KO:K01681] [EC:4.2.1.3]
BN42_10287  fadA; Putative acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase) [KO:K00626] [EC:2.3.1.9]
BN42_20639  fadA; Putative acyl-CoA thiolase FadA [KO:K00626] [EC:2.3.1.9]
BN42_90014  ltp; Putative lipid carrier protein or Keto acyl-CoA thiolase Ltp3 [KO:K00626] [EC:2.3.1.9]
BN42_30132  Putative Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BN42_21228  fadA; Putative Acetyl-CoA acetyltransferase FadA4 (Acetoacetyl-CoA Thiolase) [KO:K00626] [EC:2.3.1.9]
BN42_20703  Putative lipid carrier protein or keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
BN42_20922  fadA; Putative beta-ketoacyl CoA thiolase FadA3 [KO:K00626] [EC:2.3.1.9]
BN42_90041  fadA; Putative acetyl-CoA acetyltransferase FadA5 (acetoacetyl-CoA thiolase) [KO:K00626] [EC:2.3.1.9]
BN42_90051  fadA; Putative Acetyl-CoA Acetyltransferase FadA6 (Acetoacetyl-CoA Thiolase) [KO:K00626] [EC:2.3.1.9]
BN42_21227  Conserved protein of unknown function [KO:K05606] [EC:5.1.99.1]
BN42_41343  accA; Putative bifunctional protein acetyl-/propionyl-coenzyme A carboxylase (alpha chain) AccA3: biotin carboxylase + biotin carboxyl carrier protein (BCCP) [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
BN42_41337  accD; Putative propionyl-CoA carboxylase beta chain 5 AccD5 (PCCase) (propanoyl-CoA:carbon dioxide ligase) [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
BN42_41339  Conserved protein of unknown function (part 2) [KO:K27095]
BN42_40171  accD; Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
BN42_21418  mutA; Methylmalonyl-CoA mutase small subunit MutA (MCM) [KO:K01847] [EC:5.4.99.2]
BN42_21419  mutB; Putative methylmalonyl-CoA mutase large subunit MutB (mcm) [KO:K01847] [EC:5.4.99.2]
BN42_21131  Putative oxidoreductase [KO:K00104] [EC:1.1.99.14]
BN42_40199  Putative dehydrogenase [KO:K00104] [EC:1.1.99.14]
BN42_40156  Conserved protein of unknown function [KO:K01091] [EC:3.1.3.18]
BN42_30145  glnA; Putative glutamine synthetase GlnA3 (glutamine synthase) (GS-I) [KO:K01915] [EC:6.3.1.2]
BN42_40140  glnA; Glutamine synthetase GlnA1 (glutamine synthase) (GS-I) [KO:K01915] [EC:6.3.1.2]
BN42_40142  glnA; Putative glutamine synthetase GlnA2 (glutamine synthase) (GS-II) [KO:K01915] [EC:6.3.1.2]
BN42_40853  glnA; Putative glutamine synthetase GlnA4 (glutamine synthase) (GS-II) [KO:K01915] [EC:6.3.1.2]
BN42_10103  glyA; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
BN42_20940  glyA; PUTATIVE Serine hydroxymethyltransferase 1 glyA1 [KO:K00600] [EC:2.1.2.1]
BN42_30093  gcvP; Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex [KO:K00281] [EC:1.4.4.2]
BN42_40128  gcvT; Putative aminomethyltransferase GcvT (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
BN42_20186  lpd; Dihydrolipoamide dehydrogenase Lpd (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphorase) [KO:K00382] [EC:1.8.1.4]
BN42_30087  gcvH; Putative glycine cleavage system H protein GcvH [KO:K02437]
BN42_40121  Conserved protein of unknown function [KO:K00865] [EC:2.7.1.165]
BN42_21121  kgd; Oxoglutarate dehydrogenase SucA (alpha-ketoglutarate dehydrogenase) [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
BN42_40964  purU; Putative formyltetrahydrofolate deformylase PurU (formyl-FH(4) hydrolase) [KO:K01433] [EC:3.5.1.10]
BN42_10158  oxcA; Putative oxalyl-CoA decarboxylase OxcA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mcx00010  Glycolysis / Gluconeogenesis
mcx00020  Citrate cycle (TCA cycle)
mcx00030  Pentose phosphate pathway
mcx00053  Ascorbate and aldarate metabolism
mcx00071  Fatty acid degradation
mcx00230  Purine metabolism
mcx00250  Alanine, aspartate and glutamate metabolism
mcx00260  Glycine, serine and threonine metabolism
mcx00620  Pyruvate metabolism
mcx00710  Carbon fixation by Calvin cycle
mcx00750  Vitamin B6 metabolism
mcx00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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