KEGG   PATHWAY: minc00480
Entry
minc00480                   Pathway                                
Name
Glutathione metabolism - Mangifera indica (mango)
Class
Metabolism; Metabolism of other amino acids
Pathway map
minc00480  Glutathione metabolism
minc00480

Module
minc_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:minc00480]
Other DBs
GO: 0006749
Organism
Mangifera indica (mango) [GN:minc]
Gene
123205431  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
123194612  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
123222787  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
123228869  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
123194056  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
123220269  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
123204691  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
123212125  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
123209616  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
123200692  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
123194853  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
123204531  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
123211425  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
123201466  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123201546  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123201547  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123201640  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123201802  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123214403  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
123202158  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123202307  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123202759  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
123202760  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
123226122  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
123226527  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
123226539  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
123215115  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123215583  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123192861  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
123192862  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
123204692  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
123216606  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
123216607  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
123216608  glutathione S-transferase F8, chloroplastic-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123216726  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
123216728  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
123228701  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228710  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228719  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228730  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228741  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228749  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228759  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228769  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228778  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123228903  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
123217623  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
123228998  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
123229163  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
123229172  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123229182  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
123218244  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
123218461  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
123218784  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123208616  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
123219898  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123219899  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123220178  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123220500  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123220800  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123220801  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123220802  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
123210157  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
123210236  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
123211704  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
123212910  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
123224370  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
123228042  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
123230317  glutathione S-transferase DHAR1, mitochondrial-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
123197901  glutathione S-transferase DHAR3, chloroplastic isoform X1 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
123196267  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
123221935  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
123196379  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
123197283  isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
123197920  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
123222449  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like isoform X1 [KO:K00031] [EC:1.1.1.42]
123214138  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123225818  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123204591  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123205950  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123210218  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123198119  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
123213439  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123215908  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123216885  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123217666  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123196615  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123209431  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123222616  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
123200680  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic-like [KO:K00432] [EC:1.11.1.9]
123192173  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
123193308  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
123210605  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
123211147  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
123211150  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
123211151  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
123221339  LOW QUALITY PROTEIN: 1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
123229373  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
123214626  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
123215635  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
123204769  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
123206531  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
123210134  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
123198152  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
123201325  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
123224991  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
123214773  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
123203234  L-ascorbate peroxidase S, chloroplastic/mitochondrial-like isoform X1 [KO:K00434] [EC:1.11.1.11]
123228152  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
123229226  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
123194353  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
123206824  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
123207163  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
123209556  L-ascorbate peroxidase, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
123198607  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
123212144  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
123200457  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
123198525  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
123211731  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
123192521  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
123227986  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
123210301  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
minc00220  Arginine biosynthesis
minc00250  Alanine, aspartate and glutamate metabolism
minc00270  Cysteine and methionine metabolism
minc00430  Taurine and hypotaurine metabolism
minc00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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