KEGG   PATHWAY: minc04144
Entry
minc04144                   Pathway                                
Name
Endocytosis - Mangifera indica (mango)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
minc04144  Endocytosis
minc04144

Other DBs
GO: 0006897
Organism
Mangifera indica (mango) [GN:minc]
Gene
123225713  phosphatidylinositol 4-phosphate 5-kinase 5-like [KO:K00889] [EC:2.7.1.68]
123226664  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
123203685  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
123192671  LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase 6-like [KO:K00889] [EC:2.7.1.68]
123192755  phosphatidylinositol 4-phosphate 5-kinase 6 [KO:K00889] [EC:2.7.1.68]
123205473  phosphatidylinositol 4-phosphate 5-kinase 4-like [KO:K00889] [EC:2.7.1.68]
123206127  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
123229102  phosphatidylinositol 4-phosphate 5-kinase 1-like [KO:K00889] [EC:2.7.1.68]
123220276  phosphatidylinositol 4-phosphate 5-kinase 9-like [KO:K00889] [EC:2.7.1.68]
123198099  phosphatidylinositol 4-phosphate 5-kinase 4-like [KO:K00889] [EC:2.7.1.68]
123212951  phosphatidylinositol 4-phosphate 5-kinase 7 isoform X1 [KO:K00889] [EC:2.7.1.68]
123213376  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
123215574  phospholipase D beta 2-like [KO:K01115] [EC:3.1.4.4]
123228963  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
123194471  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
123206765  phospholipase D zeta 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
123194987  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
123207406  phospholipase D alpha 1-like [KO:K01115] [EC:3.1.4.4]
123219248  phospholipase D alpha 1-like isoform X1 [KO:K01115] [EC:3.1.4.4]
123209016  phospholipase D zeta 2-like isoform X1 [KO:K01115] [EC:3.1.4.4]
123221023  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
123221221  LOW QUALITY PROTEIN: phospholipase D zeta 1-like [KO:K01115] [EC:3.1.4.4]
123210457  phospholipase D alpha 1 [KO:K01115] [EC:3.1.4.4]
123211218  phospholipase D gamma 1-like [KO:K01115] [EC:3.1.4.4]
123223321  phospholipase D beta 2-like [KO:K01115] [EC:3.1.4.4]
123199363  phospholipase D delta-like [KO:K01115] [EC:3.1.4.4]
123211862  phospholipase D zeta 1 isoform X1 [KO:K01115] [EC:3.1.4.4]
123212511  phospholipase D alpha 4 [KO:K01115] [EC:3.1.4.4]
123202956  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
123214588  dynamin-2A-like isoform X1 [KO:K01528] [EC:3.6.5.5]
123193716  dynamin-2A-like isoform X1 [KO:K01528] [EC:3.6.5.5]
123229329  dynamin-2A-like [KO:K01528] [EC:3.6.5.5]
123227045  clathrin heavy chain 1 [KO:K04646]
123193519  clathrin heavy chain 1-like [KO:K04646]
123225697  AP-2 complex subunit alpha-1-like [KO:K11824]
123209225  AP-2 complex subunit alpha-1-like isoform X1 [KO:K11824]
123229126  AP-2 complex subunit mu-like [KO:K11826]
123196984  AP-2 complex subunit mu [KO:K11826]
123224126  AP-2 complex subunit mu-like isoform X1 [KO:K11826]
123202713  AP-2 complex subunit sigma [KO:K11827]
123229503  AP-2 complex subunit sigma-like [KO:K11827]
123201644  epsin-3-like [KO:K12471]
123192034  epsin-3-like [KO:K12471]
123192036  epsin-3-like [KO:K12471]
123205723  clathrin interactor EPSIN 2-like isoform X1 [KO:K12471]
123193953  clathrin interactor EPSIN 1 isoform X1 [KO:K12471]
123196204  clathrin interactor EPSIN 2-like isoform X1 [KO:K12471]
123221148  clathrin interactor EPSIN 2-like [KO:K12471]
123208742  epidermal growth factor receptor substrate 15-like isoform X1 [KO:K12472]
123199176  epidermal growth factor receptor substrate 15-like [KO:K12472]
123214694  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
123199736  protein EARLY-RESPONSIVE TO DEHYDRATION 7, chloroplastic-like [KO:K19366]
123223715  actin-related protein 2 isoform X1 [KO:K17260]
123214800  actin-related protein 3-like [KO:K18584]
123216991  actin-related protein 3 [KO:K18584]
123196173  actin-related protein 2/3 complex subunit 1B-like [KO:K05757]
123226970  actin-related protein 2/3 complex subunit 2A [KO:K05758]
123219176  actin-related protein 2/3 complex subunit 2A-like [KO:K05758]
123210147  actin-related protein 2/3 complex subunit 2B isoform X1 [KO:K05758]
123195202  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
123199942  actin-related protein 2/3 complex subunit 3 [KO:K05756]
123212524  actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
123214708  actin-related protein 2/3 complex subunit 5A isoform X1 [KO:K05754]
123227222  actin-related protein 2/3 complex subunit 5A-like [KO:K05754]
123206646  actin-related protein 2/3 complex subunit 5A isoform X1 [KO:K05754]
123225205  heat shock cognate 70 kDa protein 2-like [KO:K03283]
123202040  heat shock 70 kDa protein 1 [KO:K03283]
123214219  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
123192511  heat shock cognate 70 kDa protein 2-like [KO:K03283]
123227671  heat shock cognate 70 kDa protein 2 [KO:K03283]
123192813  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
123192814  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
123205045  heat shock 70 kDa protein 4-like [KO:K03283]
123217347  heat shock 70 kDa protein 1-like [KO:K03283]
123194060  heat shock 70 kDa protein [KO:K03283]
123218116  heat shock 70 kDa protein-like [KO:K03283]
123211939  heat shock cognate 70 kDa protein-like [KO:K03283]
123212230  heat shock cognate 70 kDa protein-like [KO:K03283]
123198007  F-actin-capping protein subunit alpha [KO:K10364]
123202593  probable F-actin-capping protein subunit beta isoform X1 [KO:K10365]
123229993  probable F-actin-capping protein subunit beta [KO:K10365]
123215921  vacuolar protein sorting-associated protein 29-like [KO:K18467]
123207090  vacuolar protein sorting-associated protein 29 [KO:K18467]
123211749  vacuolar protein sorting-associated protein 29-like [KO:K18467]
123202029  vacuolar protein sorting-associated protein 26A [KO:K18466]
123226852  vacuolar protein sorting-associated protein 26A-like [KO:K18466]
123203192  vacuolar protein sorting-associated protein 35B-like isoform X1 [KO:K18468]
123215344  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
123199096  vacuolar protein sorting-associated protein 35A-like [KO:K18468]
123204630  AMSH-like ubiquitin thioesterase 1 isoform X1 [KO:K11866] [EC:3.4.19.12]
123207386  AMSH-like ubiquitin thioesterase 2 isoform X1 [KO:K11866] [EC:3.4.19.12]
123197070  AMSH-like ubiquitin thioesterase 1 [KO:K11866] [EC:3.4.19.12]
123221615  AMSH-like ubiquitin thioesterase 3 isoform X1 [KO:K11866] [EC:3.4.19.12]
123211977  AMSH-like ubiquitin thioesterase 3 isoform X1 [KO:K11866] [EC:3.4.19.12]
123213022  AMSH-like ubiquitin thioesterase 2 isoform X1 [KO:K11866] [EC:3.4.19.12]
123213104  ras-related protein Rab7 [KO:K07897]
123202590  ras-related protein Rab7 [KO:K07897]
123226854  ras-related protein Rab7-like [KO:K07897]
123199677  ras-related protein Rab7-like [KO:K07897]
123200511  ras-related protein Rab7 [KO:K07897]
123192176  protein ELC-like [KO:K12183]
123192328  protein ELC-like [KO:K12183]
123212298  protein ELC-like [KO:K12183]
123193732  vacuolar protein sorting-associated protein 28 homolog 2 [KO:K12184]
123219360  vacuolar protein sorting-associated protein 28 homolog 2-like [KO:K12184]
123201609  vacuolar protein-sorting-associated protein 37 homolog 1-like [KO:K12185]
123194214  vacuolar protein-sorting-associated protein 37 homolog 1 [KO:K12185]
123201739  vacuolar protein sorting-associated protein 22 homolog 1-like [KO:K12188]
123201874  vacuolar protein sorting-associated protein 22 homolog 1-like [KO:K12188]
123201934  vacuolar protein sorting-associated protein 22 homolog 1-like [KO:K12188]
123202364  vacuolar protein sorting-associated protein 22 homolog 1 [KO:K12188]
123193616  vacuolar protein sorting-associated protein 36 [KO:K12190]
123192320  vacuolar protein sorting-associated protein 25 [KO:K12189]
123193298  vacuolar protein sorting-associated protein 25-like isoform X1 [KO:K12189]
123194986  vacuolar protein sorting-associated protein 20 homolog 2-like [KO:K12195]
123193238  vacuolar protein sorting-associated protein 32 homolog 2 [KO:K12194]
123217920  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
123206868  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
123195295  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
123200105  vacuolar protein sorting-associated protein 32 homolog 2-like [KO:K12194]
123227680  vacuolar protein sorting-associated protein 24 homolog 1-like [KO:K12193]
123224761  vacuolar protein sorting-associated protein 24 homolog 1 [KO:K12193]
123227594  vacuolar protein sorting-associated protein 2 homolog 2-like [KO:K12191]
123194102  vacuolar protein sorting-associated protein 2 homolog 1 [KO:K12191]
123206325  vacuolar protein sorting-associated protein 2 homolog 2-like isoform X1 [KO:K12191]
123199938  vacuolar protein sorting-associated protein 2 homolog 1-like [KO:K12191]
123216219  vacuolar protein sorting-associated protein 2 homolog 3 [KO:K12192]
123216761  charged multivesicular body protein 7 [KO:K15053]
123208948  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1 [KO:K12196]
123224721  protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like [KO:K12196]
123201269  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5-like [KO:K12199]
123227901  protein HOMOLOG OF MAMMALIAN LYST-INTERACTING PROTEIN 5-like [KO:K12199]
123206370  ESCRT-related protein CHMP1B-like [KO:K12197]
123219477  ESCRT-related protein CHMP1B-like [KO:K12197]
123211959  ESCRT-related protein CHMP1B [KO:K12197]
123192502  vacuolar protein sorting-associated protein 60.2-like [KO:K12198]
123193450  vacuolar protein sorting-associated protein 60.1-like [KO:K12198]
123213347  vacuolar-sorting protein BRO1 [KO:K12200]
123216918  vacuolar-sorting protein BRO1-like [KO:K12200]
123211498  maspardin isoform X1 [KO:K19367]
123227463  sorting nexin 1 [KO:K17917]
123200822  ras-related protein RHN1-like isoform X1 [KO:K07888]
123194608  ras-related protein Rab5-like isoform X1 [KO:K07888]
123224976  ras-related protein RHN1 [KO:K07889]
123211416  ras-related protein RHN1-like isoform X1 [KO:K07889]
123192393  EH domain-containing protein 1-like isoform X1 [KO:K12483]
123218845  EH domain-containing protein 1-like [KO:K12483]
123221982  EH domain-containing protein 1 [KO:K12483]
123202546  vacuolar protein sorting-associated protein 45 homolog isoform X1 [KO:K12479]
123229847  vacuolar protein sorting-associated protein 45 homolog isoform X1 [KO:K12479]
123201169  ras-related protein RABE1c-like [KO:K07901]
123201310  ras-related protein RABE1c-like [KO:K07901]
123201426  ras-related protein RABE1c [KO:K07901]
123226492  ras-related protein RABE1c-like [KO:K07901]
123216212  ras-related protein RABE1c-like [KO:K07901]
123227674  ras-related protein RABE1c-like [KO:K07901]
123193438  ras-related protein RABE1a-like [KO:K07901]
123194414  ras-related protein RABE1c-like [KO:K07901]
123209160  ras-related protein RABE1c-like [KO:K07901]
123221494  ras-related protein RABE1c-like [KO:K07901]
123213450  ras-related protein RABA2a-like isoform X1 [KO:K07904]
123224953  ras-related protein Rab11C-like [KO:K07904]
123214013  ras-related protein RABA4c-like [KO:K07904]
123227380  ras-related protein Rab11C-like [KO:K07904]
123216134  ras-related protein RABA3-like [KO:K07904]
123192728  ras-related protein Rab2BV-like [KO:K07904]
123192854  ras-related protein RABA1d-like [KO:K07904]
123193034  ras-related protein RABA1f-like [KO:K07904]
123193627  ras-related protein RABA5a [KO:K07904]
123193665  ras-related protein RABA2a [KO:K07904]
123217921  ras-related protein RABA5a-like [KO:K07904]
123206963  ras-related protein Rab11C-like [KO:K07904]
123218018  ras-related protein RABA1f-like [KO:K07904]
123219213  ras-related protein RIC2 [KO:K07904]
123195443  ras-related protein RABA1f [KO:K07904]
123207908  ras-related protein RABA1d-like [KO:K07904]
123208280  ras-related protein Rab11C [KO:K07904]
123220148  ras-related protein RABA5c-like [KO:K07904]
123196333  ras-related protein Rab11D-like isoform X1 [KO:K07904]
123197201  ras-related protein RABA4d [KO:K07904]
123210185  ras-related protein Rab11A [KO:K07904]
123221815  ras-related protein RABA5c [KO:K07904]
123199671  ras-related protein Rab11D [KO:K07904]
123223813  ras-related protein RABA3-like [KO:K07904]
123224279  ras-related protein RABA1f-like [KO:K07904]
123224333  ras-related protein Rab11D [KO:K07904]
123227455  ras-related protein RABA1f [KO:K07904]
123202072  ADP-ribosylation factor GTPase-activating protein AGD5-like [KO:K12486]
123226735  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
123227015  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
123192175  ADP-ribosylation factor GTPase-activating protein AGD5-like [KO:K12486]
123192852  probable ADP-ribosylation factor GTPase-activating protein AGD11 [KO:K12486]
123205285  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
123218618  ADP-ribosylation factor GTPase-activating protein AGD5-like [KO:K12486]
123195175  ADP-ribosylation factor GTPase-activating protein AGD5 isoform X1 [KO:K12486]
123219154  ADP-ribosylation factor GTPase-activating protein AGD12-like [KO:K12486]
123197011  probable ADP-ribosylation factor GTPase-activating protein AGD15 [KO:K12486]
123213518  ADP-ribosylation factor GTPase-activating protein AGD4-like isoform X1 [KO:K12489]
123227465  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
123192905  ADP-ribosylation factor GTPase-activating protein AGD3-like [KO:K12489]
123216814  ADP-ribosylation factor GTPase-activating protein AGD1-like isoform X1 [KO:K12489]
123222872  ADP-ribosylation factor GTPase-activating protein AGD1-like isoform X1 [KO:K12489]
123201543  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
123230108  probable ADP-ribosylation factor GTPase-activating protein AGD6 [KO:K12492]
123196805  probable ADP-ribosylation factor GTPase-activating protein AGD8 [KO:K12493]
123223863  probable ADP-ribosylation factor GTPase-activating protein AGD8 isoform X1 [KO:K12493]
123213637  brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
123227073  brefeldin A-inhibited guanine nucleotide-exchange protein 1-like isoform X1 [KO:K18442]
123216311  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like isoform X1 [KO:K18442]
123222528  brefeldin A-inhibited guanine nucleotide-exchange protein 2-like [KO:K18442]
123200862  ARF guanine-nucleotide exchange factor GNL2 [KO:K18443]
123213940  ARF guanine-nucleotide exchange factor GNOM [KO:K18443]
123225892  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
123206912  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
123197753  ARF guanine-nucleotide exchange factor GNOM-like [KO:K18443]
123213915  ADP-ribosylation factor 1-like [KO:K07937]
123215105  ADP-ribosylation factor 2-like [KO:K07937]
123203549  ADP-ribosylation factor 1-like 2 [KO:K07937]
123205120  ADP-ribosylation factor 1-like 2 [KO:K07937]
123217049  ADP-ribosylation factor [KO:K07937]
123217203  ADP-ribosylation factor 2 [KO:K07937]
123206645  ADP-ribosylation factor 1-like [KO:K07937]
123207382  ADP-ribosylation factor-like [KO:K07937]
123195783  ADP-ribosylation factor-like [KO:K07937]
123208879  ADP-ribosylation factor [KO:K07937]
123221627  ADP-ribosylation factor 1-like 2 [KO:K07937]
123221733  ADP-ribosylation factor [KO:K07937]
123198778  ADP-ribosylation factor 1-like [KO:K07937]
123222702  ADP-ribosylation factor-like [KO:K07937]
123224385  ADP-ribosylation factor-like [KO:K07937]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
minc04070  Phosphatidylinositol signaling system
minc04130  SNARE interactions in vesicular transport
KO pathway
ko04144   
LinkDB

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