KEGG   PATHWAY: ming00480
Entry
ming00480                   Pathway                                
Name
Glutathione metabolism - Macadamia integrifolia (macadamia nut)
Class
Metabolism; Metabolism of other amino acids
Pathway map
ming00480  Glutathione metabolism
ming00480

Module
ming_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:ming00480]
Other DBs
GO: 0006749
Organism
Macadamia integrifolia (macadamia nut) [GN:ming]
Gene
122061106  glutathione hydrolase 3-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122074639  glutathione hydrolase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
122079645  gamma-glutamylcyclotransferase 2-3 isoform X1 [KO:K22596] [EC:4.3.2.9]
122071607  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
122093967  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
122093975  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
122092163  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122092165  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122068137  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122057340  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
122084280  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
122084513  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
122086445  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
122059806  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122059808  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122060094  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122060098  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122060112  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122060118  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122060194  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122060210  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122060211  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122075676  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122088219  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122088409  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122088667  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
122061300  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122061520  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
122076831  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
122062049  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
122089454  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122062485  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122063286  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122063350  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122077780  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122078835  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122078836  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122078873  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122079065  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
122079761  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122079762  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122079764  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
122080127  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122080129  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122080242  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
122080327  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122080653  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122080851  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122093025  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
122093232  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
122093307  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122093509  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122094179  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122068534  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122068618  glutathione transferase GST 23-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122068700  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122068709  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122068710  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122068718  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
122068719  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
122068720  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122081930  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
122082024  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
122082060  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122082143  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
122082641  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122083088  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122083149  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
122083163  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122083164  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122070338  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
122070681  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122083797  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122083952  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122071387  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
122072695  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
122085052  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122085168  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122073247  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
122086687  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122086689  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
122058628  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122058741  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
122058775  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
122058776  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122058797  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
122058820  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122075307  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
122087981  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
122059306  glutathione S-transferase U25-like [KO:K00799] [EC:2.5.1.18]
122078463  glutathione S-transferase DHAR3, chloroplastic-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122069365  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
122077539  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
122089831  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
122091806  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
122089123  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
122080027  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
122078990  6-phosphogluconate dehydrogenase, decarboxylating 2-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122058479  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122087281  6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
122088261  glucose-6-phosphate 1-dehydrogenase 6, cytoplasmic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122077084  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122078229  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122092924  LOW QUALITY PROTEIN: glucose-6-phosphate 1-dehydrogenase-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122093627  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122075416  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122059112  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
122060534  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122092448  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
122067695  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
122083629  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122088124  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
122057299  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
122075831  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
122078749  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
122075772  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122077746  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
122080744  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
122082707  spermine synthase [KO:K00797] [EC:2.5.1.16]
122075921  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
122090469  LOW QUALITY PROTEIN: probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
122063806  L-ascorbate peroxidase 3-like isoform X1 [KO:K00434] [EC:1.11.1.11]
122071585  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
122085172  probable L-ascorbate peroxidase 4, peroxisomal isoform X1 [KO:K00434] [EC:1.11.1.11]
122057883  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
122087413  L-ascorbate peroxidase 2, cytosolic-like [KO:K00434] [EC:1.11.1.11]
122072002  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
122074597  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
122093168  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
122081210  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
122057365  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
ming00220  Arginine biosynthesis
ming00250  Alanine, aspartate and glutamate metabolism
ming00270  Cysteine and methionine metabolism
ming00430  Taurine and hypotaurine metabolism
ming00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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