KEGG   PATHWAY: mmur00020
Entry
mmur00020                   Pathway                                
Name
Citrate cycle (TCA cycle) - Microcebus murinus (gray mouse lemur)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mmur00020  Citrate cycle (TCA cycle)
mmur00020

Module
mmur_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mmur00020]
mmur_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:mmur00020]
mmur_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:mmur00020]
mmur_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:mmur00020]
mmur_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mmur00020]
Other DBs
GO: 0006099
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105865295  CS; citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
105872020  ACLY; ATP-citrate synthase isoform X1 [KO:K01648] [EC:2.3.3.8]
105871182  ACO1; cytoplasmic aconitate hydratase [KO:K01681] [EC:4.2.1.3]
105858489  ACO2; aconitate hydratase, mitochondrial [KO:K01681] [EC:4.2.1.3]
105870612  IDH2; isocitrate dehydrogenase [NADP], mitochondrial [KO:K00031] [EC:1.1.1.42]
105864312  IDH1; isocitrate dehydrogenase [NADP] cytoplasmic [KO:K00031] [EC:1.1.1.42]
105874184  LOW QUALITY PROTEIN: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
105867306  IDH3G; isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
105857213  IDH3A; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
105865995  IDH3B; isocitrate dehydrogenase [NAD] subunit beta, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
105860127  OGDHL; 2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1 [KO:K00164] [EC:1.2.4.2]
105870651  OGDH; 2-oxoglutarate dehydrogenase, mitochondrial isoform X1 [KO:K00164] [EC:1.2.4.2]
105858759  DLST; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
105860915  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
105876575  SUCLG1; succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
105868516  SUCLA2; succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial isoform X1 [KO:K01900] [EC:6.2.1.4 6.2.1.5]
105862324  SUCLG2; succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
105866564  LOW QUALITY PROTEIN: succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial-like [KO:K01900] [EC:6.2.1.4 6.2.1.5]
105876466  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105870472  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105882171  succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105873557  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105862943  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105863187  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105878054  fumarate hydratase, mitochondrial-like [KO:K01679] [EC:4.2.1.2]
105863788  FH; fumarate hydratase, mitochondrial [KO:K01679] [EC:4.2.1.2]
105871518  MDH1; malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
105868340  MDH2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
105867491  PC; pyruvate carboxylase, mitochondrial isoform X1 [KO:K01958] [EC:6.4.1.1]
105874534  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
105866581  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
105882374  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105870784  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
105884921  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
105862936  DLAT; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mmur00010  Glycolysis / Gluconeogenesis
mmur00053  Ascorbate and aldarate metabolism
mmur00061  Fatty acid biosynthesis
mmur00062  Fatty acid elongation
mmur00071  Fatty acid degradation
mmur00190  Oxidative phosphorylation
mmur00220  Arginine biosynthesis
mmur00250  Alanine, aspartate and glutamate metabolism
mmur00280  Valine, leucine and isoleucine degradation
mmur00350  Tyrosine metabolism
mmur00470  D-Amino acid metabolism
mmur00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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