KEGG   PATHWAY: mof00480
Entry
mof00480                    Pathway                                
Name
Glutathione metabolism - Malania oleifera
Class
Metabolism; Metabolism of other amino acids
Pathway map
mof00480  Glutathione metabolism
mof00480

Module
mof_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:mof00480]
Other DBs
GO: 0006749
Organism
Malania oleifera [GN:mof]
Gene
131157475  glutathione hydrolase 3 isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131159907  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131160504  glutathione hydrolase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
131152108  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
131163136  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
131160113  5-oxoprolinase 1 [KO:K01469] [EC:3.5.2.9]
131164833  glutamate--cysteine ligase, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
131154001  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
131158891  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
131164412  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
131160949  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131161432  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131151202  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
131151331  glutathione S-transferase U4-like [KO:K00799] [EC:2.5.1.18]
131151848  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131151850  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131151851  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131162146  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
131152176  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
131163874  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131163875  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131163878  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131164400  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131164851  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
131154800  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
131144252  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
131155529  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
131144515  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
131156063  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
131156347  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
131167071  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
131157191  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
131157194  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
131157196  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
131167297  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167298  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167299  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167300  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131167301  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167302  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167303  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167304  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167306  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167307  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167308  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167309  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
131167903  glutathione S-transferase L3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
131167904  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
131159265  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
131160080  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
131165588  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
131160419  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
131151783  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
131155687  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
131144890  isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
131168462  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial isoform X1 [KO:K00031] [EC:1.1.1.42]
131159720  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
131154567  6-phosphogluconate dehydrogenase, decarboxylating 2 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
131158434  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
131154382  inactive glucose-6-phosphate 1-dehydrogenase 4, chloroplastic isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
131144802  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
131167831  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
131149424  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
131164841  probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
131164843  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
131164844  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
131156742  probable glutathione peroxidase 4 isoform X1 [KO:K00432] [EC:1.11.1.9]
131150259  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
131150317  probable glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
131151689  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
131162142  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
131144345  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
131145415  spermine synthase isoform X1 [KO:K00797] [EC:2.5.1.16]
131146282  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
131161961  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial isoform X1 [KO:K00434] [EC:1.11.1.11]
131152101  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
131155806  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
131156655  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
131167932  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
131148126  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
131160456  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
131154900  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
131155309  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
131168333  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
131150234  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
mof00220  Arginine biosynthesis
mof00250  Alanine, aspartate and glutamate metabolism
mof00270  Cysteine and methionine metabolism
mof00430  Taurine and hypotaurine metabolism
mof00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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