KEGG   PATHWAY: msak00630
Entry
msak00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium saskatchewanense
Class
Metabolism; Carbohydrate metabolism
Pathway map
msak00630  Glyoxylate and dicarboxylate metabolism
msak00630

Module
msak_M00012  Glyoxylate cycle [PATH:msak00630]
msak_M00621  Glycine cleavage system [PATH:msak00630]
msak_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:msak00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium saskatchewanense [GN:msak]
Gene
MSAS_08090  aceA; isocitrate lyase 2 [KO:K01637] [EC:4.1.3.1]
MSAS_41910  icl; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
MSAS_49780  acsA_2; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
MSAS_30230  acsA_1; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MSAS_07100  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
MSAS_20490  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
MSAS_21770  gltA1; citrate synthase [KO:K01647] [EC:2.3.3.1]
MSAS_25230  gltA2; citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
MSAS_25260  citA; putative citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
MSAS_02430  acn; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
MSAS_07400  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_15540  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_15730  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_15750  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_19050  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_19360  fadA4; putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_22520  fadA3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_24380  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_25030  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_25580  fadA_1; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_28650  ltp3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_28880  fadA5; steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MSAS_28990  fadA6; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_38330  fadA2; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_43380  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MSAS_43470  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSAS_19370  mce; methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
MSAS_47750  accA3; acetyl-/propionyl-CoA carboxylase subunit alpha [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
MSAS_47800  accD5; putative propionyl-CoA carboxylase beta chain 5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
MSAS_47790  hypothetical protein [KO:K27095]
MSAS_12220  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MSAS_02770  mutA; putative methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
MSAS_02780  mutB; putative methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
MSAS_26760  methylmalonyl-CoA mutase [KO:K01849] [EC:5.4.99.2]
MSAS_26770  methylmalonyl-CoA mutase [KO:K01848] [EC:5.4.99.2]
MSAS_49360  FAD-linked oxidase [KO:K00104] [EC:1.1.99.14]
MSAS_12690  dehydrogenase [KO:K00104] [EC:1.1.99.14]
MSAS_20310  oxidoreductase [KO:K00104] [EC:1.1.99.14]
MSAS_37050  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
MSAS_57010  srpA; catalase-related peroxidase [KO:K03781] [EC:1.11.1.6]
MSAS_31120  katA; catalase [KO:K03781] [EC:1.11.1.6]
MSAS_35050  catalase-related peroxidase [KO:K03781] [EC:1.11.1.6]
MSAS_35300  catalase-related peroxidase [KO:K03781] [EC:1.11.1.6]
MSAS_12010  hypothetical protein [KO:K01091] [EC:3.1.3.18]
MSAS_22840  cbbL; ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit [KO:K01601] [EC:4.1.1.39]
MSAS_22830  ribulose bisphosphate carboxylase small subunit [KO:K01602] [EC:4.1.1.39]
MSAS_54310  glnA4; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSAS_05140  glnA1_1; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
MSAS_05320  glnN; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSAS_07600  glnA3; glutamine synthetase GlnA [KO:K01915] [EC:6.3.1.2]
MSAS_11730  glnA1_2; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
MSAS_11840  glnA2; putative glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
MSAS_12870  glnT; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSAS_13100  type III glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
MSAS_33880  type III glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
MSAS_22350  glyA1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
MSAS_07080  gcvP; glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MSAS_11600  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MSAS_41860  lpdC; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MSAS_07020  gcvH; glycine cleavage system H protein [KO:K02437]
MSAS_49330  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
MSAS_49350  hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
MSAS_49340  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
MSAS_49380  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
MSAS_11540  hypothetical protein [KO:K00865] [EC:2.7.1.165]
MSAS_20450  kgd; multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MSAS_54250  cupin [KO:K01569] [EC:4.1.1.2]
MSAS_13530  cupin [KO:K01569] [EC:4.1.1.2]
MSAS_54940  formate dehydrogenase [KO:K00122] [EC:1.17.1.9]
MSAS_30660  formate dehydrogenase subunit alpha [KO:K00123] [EC:1.17.1.9]
MSAS_30650  4Fe-4S ferredoxin [KO:K00124]
MSAS_51170  formamidase [KO:K01455] [EC:3.5.1.49]
MSAS_54880  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSAS_09460  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSAS_36300  oxcA; oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSAS_54890  frc_2; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
MSAS_54910  frc_3; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
MSAS_09470  frc_1; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
msak00010  Glycolysis / Gluconeogenesis
msak00020  Citrate cycle (TCA cycle)
msak00030  Pentose phosphate pathway
msak00053  Ascorbate and aldarate metabolism
msak00071  Fatty acid degradation
msak00230  Purine metabolism
msak00250  Alanine, aspartate and glutamate metabolism
msak00260  Glycine, serine and threonine metabolism
msak00620  Pyruvate metabolism
msak00710  Carbon fixation by Calvin cycle
msak00750  Vitamin B6 metabolism
msak00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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