KEGG   PATHWAY: msim00630
Entry
msim00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium simiae
Class
Metabolism; Carbohydrate metabolism
Pathway map
msim00630  Glyoxylate and dicarboxylate metabolism
msim00630

Module
msim_M00012  Glyoxylate cycle [PATH:msim00630]
msim_M00621  Glycine cleavage system [PATH:msim00630]
msim_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:msim00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium simiae [GN:msim]
Gene
MSIM_17840  aceA_1; isocitrate lyase [KO:K01637] [EC:4.1.3.1]
MSIM_50440  aceA_2; isocitrate lyase 2 [KO:K01637] [EC:4.1.3.1]
MSIM_28060  acsA; acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
MSIM_51720  glcB; malate synthase G [KO:K01638] [EC:2.3.3.9]
MSIM_38850  mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
MSIM_33050  citA; putative citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
MSIM_33080  gltA2; citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
MSIM_37720  prpC; 2-methylcitrate synthase [KO:K01647] [EC:2.3.3.1]
MSIM_02070  acn; aconitate hydratase [KO:K01681] [EC:4.2.1.3]
MSIM_09550  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_20240  fadA2; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_29240  fadA6; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_29330  fadA5; steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
MSIM_29540  ltp3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_32640  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_33260  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_34750  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_37090  fadA3; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_39890  fadA4; putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_40210  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_51280  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_40460  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
MSIM_39880  methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
MSIM_13640  acetyl-/propionyl-CoA carboxylase subunit alpha [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
MSIM_13590  accD5; putative propionyl-CoA carboxylase beta chain 5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
MSIM_13600  hypothetical protein [KO:K27095]
MSIM_45140  accD6; putative propionyl-CoA carboxylase beta chain 6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
MSIM_01870  mutB; putative methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
MSIM_01880  mutA; putative methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
MSIM_31330  methylmalonyl-CoA mutase [KO:K01849] [EC:5.4.99.2]
MSIM_31320  methylmalonyl-CoA mutase [KO:K01848] [EC:5.4.99.2]
MSIM_31170  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
MSIM_39000  oxidoreductase [KO:K00104] [EC:1.1.99.14]
MSIM_44730  dehydrogenase [KO:K00104] [EC:1.1.99.14]
MSIM_46610  FAD-binding protein [KO:K00104] [EC:1.1.99.14]
MSIM_04380  srpA; catalase-related peroxidase [KO:K03781] [EC:1.11.1.6]
MSIM_23170  catalase-related peroxidase [KO:K03781] [EC:1.11.1.6]
MSIM_27440  katA; catalase [KO:K03781] [EC:1.11.1.6]
MSIM_45380  hypothetical protein [KO:K01091] [EC:3.1.3.18]
MSIM_28420  glnT; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSIM_45490  glnA2; putative glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
MSIM_45600  glnA1; glutamine synthetase 1 [KO:K01915] [EC:6.3.1.2]
MSIM_51050  glnA3; glutamine synthetase GlnA [KO:K01915] [EC:6.3.1.2]
MSIM_51550  type III glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
MSIM_53180  glnN; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
MSIM_37280  glyA1; serine hydroxymethyltransferase 1 [KO:K00600] [EC:2.1.2.1]
MSIM_51750  gcvP; putative glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
MSIM_45730  gcvT; aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
MSIM_17890  lpdC; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MSIM_46520  gcvH_1; glycine cleavage system H protein [KO:K02437]
MSIM_51810  gcvH_2; glycine cleavage system H protein [KO:K02437]
MSIM_06110  gcl; glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
MSIM_06090  hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
MSIM_06100  2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
MSIM_06080  glxK; glycerate kinase [KO:K00865] [EC:2.7.1.165]
MSIM_45790  hypothetical protein [KO:K00865] [EC:2.7.1.165]
MSIM_38900  kgd; multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
MSIM_44390  cupin [KO:K01569] [EC:4.1.1.2]
MSIM_06190  formate dehydrogenase [KO:K00122] [EC:1.17.1.9]
MSIM_23350  formate dehydrogenase subunit alpha [KO:K00123] [EC:1.17.1.9]
MSIM_23340  4Fe-4S ferredoxin [KO:K00124]
MSIM_09890  formamidase [KO:K01455] [EC:3.5.1.49]
MSIM_06250  oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSIM_22210  oxcA; oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
MSIM_06220  frc_1; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
MSIM_06240  frc_2; formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
msim00010  Glycolysis / Gluconeogenesis
msim00020  Citrate cycle (TCA cycle)
msim00030  Pentose phosphate pathway
msim00053  Ascorbate and aldarate metabolism
msim00071  Fatty acid degradation
msim00230  Purine metabolism
msim00250  Alanine, aspartate and glutamate metabolism
msim00260  Glycine, serine and threonine metabolism
msim00620  Pyruvate metabolism
msim00710  Carbon fixation by Calvin cycle
msim00750  Vitamin B6 metabolism
msim00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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