KEGG   PATHWAY: mtf00630
Entry
mtf00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Mycobacterium tuberculosis F11
Class
Metabolism; Carbohydrate metabolism
Pathway map
mtf00630  Glyoxylate and dicarboxylate metabolism
mtf00630

Module
mtf_M00012  Glyoxylate cycle [PATH:mtf00630]
mtf_M00621  Glycine cleavage system [PATH:mtf00630]
mtf_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:mtf00630]
Other DBs
GO: 0046487 0043648
Organism
Mycobacterium tuberculosis F11 [GN:mtf]
Gene
TBFG_10474  isocitrate lyase icl [KO:K01637] [EC:4.1.3.1]
TBFG_11944  isocitrate lyase aceAa [KO:K01637] [EC:4.1.3.1]
TBFG_11945  isocitrate lyase aceAb [KO:K01637] [EC:4.1.3.1]
TBFG_13698  acetyl-coA synthetase acs [KO:K01895] [EC:6.2.1.1]
TBFG_11866  malate synthase G glcB [KO:K01638] [EC:2.3.3.9]
TBFG_11265  malate dehydrogenase mdh [KO:K00024] [EC:1.1.1.37]
TBFG_11154  citrate synthase I gltA1 [KO:K01647] [EC:2.3.3.1]
TBFG_10908  citrate synthase II citA [KO:K01647] [EC:2.3.3.1]
TBFG_10915  citrate synthase I gltA2 [KO:K01647] [EC:2.3.3.1]
TBFG_11504  iron-regulated aconitate hydratase acn [KO:K01681] [EC:4.2.1.3]
TBFG_10876  acyl-CoA thiolase fadA [KO:K00626] [EC:2.3.1.9]
TBFG_11355  acetyl-CoA acetyltransferase fadA4 [KO:K00626] [EC:2.3.1.9]
TBFG_13589  acetyl-CoA acetyltransferase fadA6 [KO:K00626] [EC:2.3.1.9]
TBFG_10932  hypothetical lipid carrier protein or keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
TBFG_13556  lipid carrier protein or keto acyl-CoA thiolase ltp3 [KO:K00626] [EC:2.3.1.9]
TBFG_13579  acetyl-CoA acetyltransferase fadA5 [KO:K00626] [EC:2.3.1.9]
TBFG_10246  acetyl-CoA acyltransferase fadA2 [KO:K00626] [EC:2.3.1.9]
TBFG_11092  beta-ketoacyl CoA thiolase fadA3 [KO:K00626] [EC:2.3.1.9]
TBFG_11895  conserved hypothetical protein [KO:K00626] [EC:2.3.1.9]
TBFG_11354  conserved hypothetical protein [KO:K05606] [EC:5.1.99.1]
TBFG_13314  bifunctional protein acetyl-/propionyl-coenzyme A carboxylase alpha subunit accA3: biotin carboxylase + biotin carboxyl carrier protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
TBFG_13309  propionyl-CoA carboxylase beta subunit 5 accD5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
TBFG_13310  conserved hypothetical protein [KO:K27095]
TBFG_12276  propionyl-CoA carboxylase beta subunit 6 accD6 [KO:K18472] [EC:6.4.1.2 6.4.1.3 2.1.3.15]
TBFG_11523  methylmalonyl-CoA mutase large subunit mutB [KO:K01847] [EC:5.4.99.2]
TBFG_11522  methylmalonyl-CoA mutase small subunit mutA [KO:K01847] [EC:5.4.99.2]
TBFG_12303  hypothetical dehydrogenase [KO:K00104] [EC:1.1.99.14]
TBFG_11283  hypothetical oxidoreductase [KO:K00104] [EC:1.1.99.14]
TBFG_12251  glutamine synthetase glnA2 [KO:K01915] [EC:6.3.1.2]
TBFG_12249  glutamine synthetase glnA1 [KO:K01915] [EC:6.3.1.2]
TBFG_12876  glutamine synthetase glnA4 [KO:K01915] [EC:6.3.1.2]
TBFG_11906  glutamine synthetase glnA3 [KO:K01915] [EC:6.3.1.2]
TBFG_11114  serine hydroxymethyltransferase 1 glyA1 [KO:K00600] [EC:2.1.2.1]
TBFG_10070  serine hydroxymethyltransferase 2 glyA2 [KO:K00600] [EC:2.1.2.1]
TBFG_11861  glycine dehydrogenase gcvB [KO:K00281] [EC:1.4.4.2]
TBFG_12239  aminomethyltransferase gcvT (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
TBFG_10469  dihydrolipoamide dehydrogenase lpd [KO:K00382] [EC:1.8.1.4]
TBFG_11856  glycine cleavage system H protein gcvH [KO:K02437]
TBFG_12233  conserved hypothetical protein [KO:K00865] [EC:2.7.1.165]
TBFG_11274  2-oxoglutarate dehydrogenase sucA [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
TBFG_12978  formyltetrahydrofolate deformylase purU [KO:K01433] [EC:3.5.1.10]
TBFG_10119  oxalyl-CoA decarboxylase oxcA [KO:K01577] [EC:4.1.1.8]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
mtf00010  Glycolysis / Gluconeogenesis
mtf00020  Citrate cycle (TCA cycle)
mtf00030  Pentose phosphate pathway
mtf00053  Ascorbate and aldarate metabolism
mtf00071  Fatty acid degradation
mtf00230  Purine metabolism
mtf00250  Alanine, aspartate and glutamate metabolism
mtf00260  Glycine, serine and threonine metabolism
mtf00620  Pyruvate metabolism
mtf00710  Carbon fixation by Calvin cycle
mtf00750  Vitamin B6 metabolism
mtf00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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