KEGG   PATHWAY: mus00020
Entry
mus00020                    Pathway                                
Name
Citrate cycle (TCA cycle) - Musa acuminata (wild Malaysian banana)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:M00009], but contain genes for specific segments [MD:M00010 M00011].
Class
Metabolism; Carbohydrate metabolism
Pathway map
mus00020  Citrate cycle (TCA cycle)
mus00020

Module
mus_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:mus00020]
mus_M00009  Citrate cycle (TCA cycle, Krebs cycle) [PATH:mus00020]
mus_M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:mus00020]
mus_M00011  Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:mus00020]
mus_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:mus00020]
Other DBs
GO: 0006099
Organism
Musa acuminata (wild Malaysian banana) [GN:mus]
Gene
104000860  citrate synthase 3, peroxisomal [KO:K01647] [EC:2.3.3.1]
103983279  LOW QUALITY PROTEIN: citrate synthase, mitochondrial-like [KO:K01647] [EC:2.3.3.1]
103993325  ATP-citrate synthase beta chain protein 1-like [KO:K01648] [EC:2.3.3.8]
103993707  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
103972390  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
103970434  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
103984457  ATP-citrate synthase alpha chain protein 2 [KO:K01648] [EC:2.3.3.8]
103996973  ATP-citrate synthase beta chain protein 1 [KO:K01648] [EC:2.3.3.8]
103970120  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
103971656  aconitate hydratase, cytoplasmic-like [KO:K01681] [EC:4.2.1.3]
103983687  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
103999530  putative aconitate hydratase, cytoplasmic [KO:K01681] [EC:4.2.1.3]
103980394  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
103991634  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
103976616  isocitrate dehydrogenase [NADP]-like isoform X2 [KO:K00031] [EC:1.1.1.42]
103972343  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
103989910  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like isoform X1 [KO:K00031] [EC:1.1.1.42]
104000275  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
103976802  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030] [EC:1.1.1.41]
103997179  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial isoform X1 [KO:K00030] [EC:1.1.1.41]
103989292  isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like [KO:K00030] [EC:1.1.1.41]
103974592  isocitrate dehydrogenase [NAD] catalytic subunit 5, mitochondrial [KO:K00030] [EC:1.1.1.41]
103986147  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
103994059  2-oxoglutarate dehydrogenase, mitochondrial-like [KO:K00164] [EC:1.2.4.2]
103969312  2-oxoglutarate dehydrogenase, mitochondrial [KO:K00164] [EC:1.2.4.2]
103979443  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
103996643  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like [KO:K00658] [EC:2.3.1.61]
103974523  dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 2, mitochondrial-like isoform X1 [KO:K00658] [EC:2.3.1.61]
103971435  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
103969606  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
103978010  dihydrolipoyl dehydrogenase 2, chloroplastic [KO:K00382] [EC:1.8.1.4]
103995590  dihydrolipoyl dehydrogenase 1, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
103994643  probable succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
103975717  probable succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial [KO:K01899] [EC:6.2.1.4 6.2.1.5]
103994981  succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial [KO:K01900] [EC:6.2.1.4 6.2.1.5]
103990978  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103989592  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
108951441  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
103970730  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
103971850  succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
103974101  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] iron-sulfur subunit 3, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
103971629  succinate dehydrogenase subunit 3-1, mitochondrial [KO:K00236]
103974248  succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236]
103978640  succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801]
103998747  succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801]
103972052  fumarate hydratase 1, mitochondrial [KO:K01679] [EC:4.2.1.2]
103983038  malate dehydrogenase [KO:K00025] [EC:1.1.1.37]
103984851  malate dehydrogenase, cytoplasmic-like [KO:K00025] [EC:1.1.1.37]
103983870  malate dehydrogenase-like [KO:K00025] [EC:1.1.1.37]
103986793  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
103991412  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
103983570  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
103980355  malate dehydrogenase, glyoxysomal [KO:K00026] [EC:1.1.1.37]
103980951  malate dehydrogenase, mitochondrial-like [KO:K00026] [EC:1.1.1.37]
103969233  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
103985435  malate dehydrogenase, chloroplastic-like [KO:K00026] [EC:1.1.1.37]
103973720  malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
103983025  phosphoenolpyruvate carboxykinase [ATP]-like [KO:K01610] [EC:4.1.1.49]
103994961  phosphoenolpyruvate carboxykinase [ATP]-like isoform X1 [KO:K01610] [EC:4.1.1.49]
103983140  phosphoenolpyruvate carboxykinase [ATP]-like [KO:K01610] [EC:4.1.1.49]
103972144  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic-like isoform X1 [KO:K00161] [EC:1.2.4.1]
103985810  pyruvate dehydrogenase E1 component subunit alpha-3, chloroplastic [KO:K00161] [EC:1.2.4.1]
103990542  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
103969563  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
103994554  pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial [KO:K00161] [EC:1.2.4.1]
103983525  pyruvate dehydrogenase E1 component subunit beta [KO:K00162] [EC:1.2.4.1]
103986026  pyruvate dehydrogenase E1 component subunit beta-1, mitochondrial [KO:K00162] [EC:1.2.4.1]
103977571  dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
103978617  LOW QUALITY PROTEIN: dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
104000425  dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627] [EC:2.3.1.12]
103997442  dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic [KO:K00627] [EC:2.3.1.12]
103974108  dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627] [EC:2.3.1.12]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00036  Oxaloacetate
C00042  Succinate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00091  Succinyl-CoA
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00311  Isocitrate
C00417  cis-Aconitate
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C05379  Oxalosuccinate
C05381  3-Carboxy-1-hydroxypropyl-ThPP
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16254  [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
mus00010  Glycolysis / Gluconeogenesis
mus00053  Ascorbate and aldarate metabolism
mus00061  Fatty acid biosynthesis
mus00062  Fatty acid elongation
mus00071  Fatty acid degradation
mus00190  Oxidative phosphorylation
mus00220  Arginine biosynthesis
mus00250  Alanine, aspartate and glutamate metabolism
mus00280  Valine, leucine and isoleucine degradation
mus00350  Tyrosine metabolism
mus00470  D-Amino acid metabolism
mus00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00020   
LinkDB

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