KEGG   PATHWAY: mus00480
Entry
mus00480                    Pathway                                
Name
Glutathione metabolism - Musa acuminata (wild Malaysian banana)
Class
Metabolism; Metabolism of other amino acids
Pathway map
mus00480  Glutathione metabolism
mus00480

Module
mus_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:mus00480]
Other DBs
GO: 0006749
Organism
Musa acuminata (wild Malaysian banana) [GN:mus]
Gene
103987881  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
103985170  gamma-glutamyltranspeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
103988889  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
103976860  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
103977548  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
103973129  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
103996023  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
103991763  gamma-glutamylcyclotransferase 2-2-like [KO:K22596] [EC:4.3.2.9]
103996908  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
103986183  glutamate--cysteine ligase A, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
103969020  glutamate--cysteine ligase A, chloroplastic isoform X1 [KO:K01919] [EC:6.3.2.2]
103971843  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
103992278  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
103996327  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
103973393  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
103971959  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
103989732  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
103999063  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103999064  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103999066  glutathione S-transferase U19-like isoform X1 [KO:K00799] [EC:2.5.1.18]
103999067  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
103999068  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103999069  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103999070  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103999071  glutathione S-transferase U20-like [KO:K00799] [EC:2.5.1.18]
103999072  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
103996924  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
103981216  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
103976762  microsomal glutathione S-transferase 3-like isoform X2 [KO:K00799] [EC:2.5.1.18]
103982403  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
103972380  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
103985287  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
103984645  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
103984646  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
103984648  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
103970024  GSTF1; probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
103975822  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
103970644  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
103999408  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
103984202  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
103980638  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
103994318  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
103995434  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
104000389  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103997659  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
103986243  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
103999735  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
103999863  GSTL1; protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
103968552  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
103968336  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
103993924  glutathione S-transferase F10 [KO:K00799] [EC:2.5.1.18]
103993843  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
103976154  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
103994758  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
103997954  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
103989347  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
103973270  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
103973269  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
103978877  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
108951690  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
103984516  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
103974966  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
103974488  glutathione S-transferase U18-like [KO:K00799] [EC:2.5.1.18]
103975057  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
103972319  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103972337  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103990147  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103992197  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
103988968  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
103979915  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
103974926  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
103972994  glutathione reductase, cytosolic-like [KO:K00383] [EC:1.8.1.7]
103980394  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
103991634  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
103976616  isocitrate dehydrogenase [NADP]-like isoform X2 [KO:K00031] [EC:1.1.1.42]
103972343  cytosolic isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
103989910  isocitrate dehydrogenase [NADP], chloroplastic/mitochondrial-like isoform X1 [KO:K00031] [EC:1.1.1.42]
103975241  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
103983842  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
103978425  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
103973250  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
103987991  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103996001  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103997189  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103989311  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103993794  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104000681  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103970427  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
103991955  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
103970350  GPX; probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
103982674  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
103985352  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
103973267  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial [KO:K00432] [EC:1.11.1.9]
103971996  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
103973703  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
103980744  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
103981537  spermine synthase-like isoform X1 [KO:K00797] [EC:2.5.1.16]
103972693  spermidine synthase 2-like [KO:K00797] [EC:2.5.1.16]
103996309  spermine synthase-like [KO:K00797] [EC:2.5.1.16]
103993837  spermidine synthase 2 [KO:K00797] [EC:2.5.1.16]
103969335  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
103989729  L-ascorbate peroxidase, cytosolic-like [KO:K00434] [EC:1.11.1.11]
103984165  APX; L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
103985795  probable L-ascorbate peroxidase 4 [KO:K00434] [EC:1.11.1.11]
103991735  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
103992108  probable L-ascorbate peroxidase 4 [KO:K00434] [EC:1.11.1.11]
103968393  probable L-ascorbate peroxidase 6, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
103971212  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
103989062  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
103971825  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
103988520  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
103996665  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
103987117  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
103988625  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
103999358  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
mus00220  Arginine biosynthesis
mus00250  Alanine, aspartate and glutamate metabolism
mus00270  Cysteine and methionine metabolism
mus00430  Taurine and hypotaurine metabolism
mus00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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