KEGG   PATHWAY: nnu00480
Entry
nnu00480                    Pathway                                
Name
Glutathione metabolism - Nelumbo nucifera (sacred lotus)
Class
Metabolism; Metabolism of other amino acids
Pathway map
nnu00480  Glutathione metabolism
nnu00480

Module
nnu_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:nnu00480]
Other DBs
GO: 0006749
Organism
Nelumbo nucifera (sacred lotus) [GN:nnu]
Gene
104600041  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
104588242  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
104601638  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
104609647  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
104599210  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
104596079  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
104590779  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
104596385  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
104596386  glutathione synthetase, chloroplastic-like [KO:K21456] [EC:6.3.2.3]
104603286  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
104610748  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
104596022  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
104610633  puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
104596470  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
104587859  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
104594703  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
104594705  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
104598210  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
104599001  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
104598999  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
104596089  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
104599002  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
104597713  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104599214  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
104602213  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104603626  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
104602114  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104602212  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104606114  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
104606221  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104606115  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
104606094  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104605312  glutathione S-transferase L1-like [KO:K00799] [EC:2.5.1.18]
104607863  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104607862  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104608091  glutathione S-transferase F10-like [KO:K00799] [EC:2.5.1.18]
104606976  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
104607024  glutathione S-transferase F12-like [KO:K00799] [EC:2.5.1.18]
104607067  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
104613340  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104589396  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
104589395  microsomal glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
104613429  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104612913  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104613475  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
104611182  glutathione S-transferase U7-like [KO:K00799] [EC:2.5.1.18]
104591181  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104588759  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
104588758  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
104588757  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104587642  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104587638  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
104587641  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104587640  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
109113889  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
109115020  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
104594651  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104599264  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104609976  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
104602393  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
104602913  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
104585819  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
104591424  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
104599821  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
104600406  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104597825  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104600620  6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104609360  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
104592835  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104592969  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104591632  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104606613  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104611234  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
104596087  GP; probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104596421  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
104600390  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
104609149  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104608706  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
104607108  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
104611250  1-Cys peroxiredoxin-like [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
104596855  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
104603680  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
104588735  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
104588710  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
104593236  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
104600373  spermine synthase [KO:K00797] [EC:2.5.1.16]
104607898  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
104587545  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
104592451  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
104594740  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
104603616  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
104605785  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
104599944  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
104589604  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
104612844  ribonucleoside-diphosphate reductase small chain A [KO:K10808] [EC:1.17.4.1]
104591729  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
104592884  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
nnu00220  Arginine biosynthesis
nnu00250  Alanine, aspartate and glutamate metabolism
nnu00270  Cysteine and methionine metabolism
nnu00430  Taurine and hypotaurine metabolism
nnu00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

DBGET integrated database retrieval system