KEGG   PATHWAY: oeu00480
Entry
oeu00480                    Pathway                                
Name
Glutathione metabolism - Olea europaea var. sylvestris (wild olive)
Class
Metabolism; Metabolism of other amino acids
Pathway map
oeu00480  Glutathione metabolism
oeu00480

Module
oeu_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:oeu00480]
Other DBs
GO: 0006749
Organism
Olea europaea var. sylvestris (wild olive) [GN:oeu]
Gene
111407819  glutathione hydrolase 3-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111399426  glutathione hydrolase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111373088  glutathione hydrolase 1-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
111385982  gamma-glutamylcyclotransferase 2-1-like [KO:K22596] [EC:4.3.2.9]
111380792  gamma-glutamylcyclotransferase 2-3-like isoform X1 [KO:K22596] [EC:4.3.2.9]
111380821  gamma-glutamylcyclotransferase 2-3-like [KO:K22596] [EC:4.3.2.9]
111398212  uncharacterized protein LOC111398212 [KO:K22596] [EC:4.3.2.9]
111382285  5-oxoprolinase-like [KO:K01469] [EC:3.5.2.9]
111375123  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
111368480  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
111399162  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
111376243  leucine aminopeptidase 1-like isoform X1 [KO:K01255] [EC:3.4.11.1]
111376244  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
111368223  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
111389176  leucine aminopeptidase 2, chloroplastic-like [KO:K01255] [EC:3.4.11.1]
111381450  leucine aminopeptidase 2, chloroplastic-like isoform X1 [KO:K01255] [EC:3.4.11.1]
111407575  puromycin-sensitive aminopeptidase-like isoform X1 [KO:K01256] [EC:3.4.11.2]
111368476  LOW QUALITY PROTEIN: puromycin-sensitive aminopeptidase-like [KO:K01256] [EC:3.4.11.2]
111369003  uncharacterized protein LOC111369003 [KO:K00799] [EC:2.5.1.18]
111389263  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
111371623  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111401218  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111375442  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111395785  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111395786  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111395838  protein IN2-1 homolog B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111402640  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111371114  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111400940  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
111380799  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
111370940  glutathione S-transferase 3-like [KO:K00799] [EC:2.5.1.18]
111372105  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
111397175  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
111380550  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
111371784  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
111398170  glutathione S-transferase T1-like [KO:K00799] [EC:2.5.1.18]
111412399  glutathione S-transferase PARB-like [KO:K00799] [EC:2.5.1.18]
111412400  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
111394930  probable glutathione S-transferase parA isoform X1 [KO:K00799] [EC:2.5.1.18]
111390147  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111390160  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
111390163  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
111390164  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
111390166  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111404102  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
111366595  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
111378721  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111385395  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
111378105  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111378121  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111404481  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
111391060  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
111409748  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
111412874  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
111411029  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
111391083  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
111385880  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111389223  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
111401489  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
111381111  glutathione reductase, chloroplastic-like isoform X1 [KO:K00383] [EC:1.8.1.7]
111374397  glutathione reductase, chloroplastic-like [KO:K00383] [EC:1.8.1.7]
111379439  glutathione reductase, chloroplastic isoform X1 [KO:K00383] [EC:1.8.1.7]
111379667  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
111386299  isocitrate dehydrogenase [NADP]-like [KO:K00031] [EC:1.1.1.42]
111375278  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
111373339  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111400949  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111387596  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111366911  6-phosphogluconate dehydrogenase, decarboxylating 3-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111405153  6-phosphogluconate dehydrogenase, decarboxylating 1-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111407604  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111368466  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic-like [KO:K00033] [EC:1.1.1.44 1.1.1.343]
111375924  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111376337  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111370909  glucose-6-phosphate 1-dehydrogenase, chloroplastic-like [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111409286  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111391859  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
111385527  probable glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
111371782  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
111371783  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111371812  putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
111383096  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111379254  putative glutathione peroxidase 7, chloroplastic [KO:K00432] [EC:1.11.1.9]
111368465  probable glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
111368484  probable glutathione peroxidase 8 [KO:K00432] [EC:1.11.1.9]
111368485  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
111387723  probable glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]
111367780  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
111396130  spermidine synthase [KO:K00797] [EC:2.5.1.16]
111385068  spermine synthase [KO:K00797] [EC:2.5.1.16]
111403155  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
111372265  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
111387515  putative L-ascorbate peroxidase 6 isoform X1 [KO:K00434] [EC:1.11.1.11]
111393231  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
111374886  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
111399815  L-ascorbate peroxidase, cytosolic-like isoform X1 [KO:K00434] [EC:1.11.1.11]
111410119  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
111369609  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
111366817  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111377259  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111373014  ribonucleoside-diphosphate reductase large subunit-like [KO:K10807] [EC:1.17.4.1]
111373950  ribonucleoside-diphosphate reductase small chain-like [KO:K10808] [EC:1.17.4.1]
111409269  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
111369489  ribonucleoside-diphosphate reductase small chain A-like [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
oeu00220  Arginine biosynthesis
oeu00250  Alanine, aspartate and glutamate metabolism
oeu00270  Cysteine and methionine metabolism
oeu00430  Taurine and hypotaurine metabolism
oeu00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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