PATHWAY: oki00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Oncorhynchus kisutch (coho salmon)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
oki_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:oki00020 ]
oki_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:oki00020 ]
Other DBs
Organism
Oncorhynchus kisutch (coho salmon) [GN:
oki ]
Gene
109881454 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
109894507 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
109882951 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
109904051 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
109907164 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like isoform X2 [KO:K00234 ] [EC:1.3.5.1 ]
109877317 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
109877528 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
109868920 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X2 [KO:K00235 ] [EC:1.3.5.1 ]
109890222 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
109872272 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236 ]
109874962 succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236 ]
109909059 sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237 ]
109905604 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial-like [KO:K00237 ]
109898999 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial-like isoform X2 [KO:K00161 ] [EC:1.2.4.1 ]
109909898 LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161 ] [EC:1.2.4.1 ]
109872568 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
109873622 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
109873348 dlat; dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [KO:K00627 ] [EC:2.3.1.12 ]
109877917 dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
oki00053 Ascorbate and aldarate metabolism
oki00250 Alanine, aspartate and glutamate metabolism
oki00280 Valine, leucine and isoleucine degradation
oki00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs