KEGG PATHWAY: oor04330

KEGG

PATHWAY: oor04330

Entry

oor04330                    Pathway

Name

Notch signaling pathway - Orcinus orca (killer whale)

Description

The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes.

Class

Environmental Information Processing; Signal transduction

Pathway map

Notch signaling pathway

Other DBs

GO:

Organism

Orcinus orca (killer whale) [GN:oor]

Gene

DLL3; delta-like protein 3 [KO:K06051]

DLL1; delta-like protein 1 [KO:K06051]

DLL4; delta-like protein 4 [KO:K06051]

JAG1; protein jagged-1 isoform X1 [KO:K06052]

JAG2; protein jagged-2 isoform X4 [KO:K21635]

MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]

RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X2 [KO:K05948] [EC:2.4.1.222]

LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]

NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]

NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]

NOTCH3; neurogenic locus notch homolog protein 3 isoform X2 [KO:K20995]

NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]

recombining binding protein suppressor of hairless isoform X3 [KO:K06053]

RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]

HES1; transcription factor HES-1 [KO:K06054]

HES5; transcription factor HES-5 isoform X3 [KO:K06055]

HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]

HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X2 [KO:K09091]

HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]

PTCRA; pre T-cell antigen receptor alpha [KO:K06056]

NRARP; notch-regulated ankyrin repeat-containing protein [KO:K26480]

DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X7 [KO:K02353]

DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]

DVL3; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3 [KO:K02353]

NUMBL; numb-like protein isoform X2 [KO:K06057]

NUMB; protein numb homolog isoform X3 [KO:K06057]

ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]

DTX4; E3 ubiquitin-protein ligase DTX4 [KO:K06058] [EC:2.3.2.27]

DTX1; E3 ubiquitin-protein ligase DTX1 isoform X2 [KO:K06058] [EC:2.3.2.27]

DTX3L; E3 ubiquitin-protein ligase DTX3L [KO:K06058] [EC:2.3.2.27]

DTX2; probable E3 ubiquitin-protein ligase DTX2 isoform X2 [KO:K06058] [EC:2.3.2.27]

DTX3; probable E3 ubiquitin-protein ligase DTX3 isoform X1 [KO:K06058] [EC:2.3.2.27]

ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]

PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]

PSEN2; presenilin-2 isoform X3 [KO:K04522] [EC:3.4.23.-]

PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]

NCSTN; nicastrin isoform X1 [KO:K06171]

APH1A; gamma-secretase subunit APH-1A [KO:K06172]

APH1B; gamma-secretase subunit APH-1B isoform X1 [KO:K06172]

MAML2; mastermind-like protein 2 [KO:K06061]

MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]

MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]

CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]

EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]

KAT2A; histone acetyltransferase KAT2A isoform X4 [KO:K06062] [EC:2.3.1.48]

KAT2B; histone acetyltransferase KAT2B isoform X3 [KO:K06062] [EC:2.3.1.48]

SNW1; SNW domain-containing protein 1 [KO:K06063]

SNW domain-containing protein 1-like [KO:K06063]

CTBP1; C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]

CTBP2; C-terminal-binding protein 2 isoform X2 [KO:K04496] [EC:1.1.1.428]

TLE1; transducin-like enhancer protein 1 isoform X1 [KO:K04497]

TLE7; transducin-like enhancer protein 7 [KO:K04497]

TLE2; transducin-like enhancer protein 2 isoform X3 [KO:K04497]

TLE3; transducin-like enhancer protein 3 isoform X5 [KO:K04497]

TLE4; transducin-like enhancer protein 4 isoform X3 [KO:K04497]

TLE6; transducin-like enhancer protein 6 [KO:K04497]

NCOR2; nuclear receptor corepressor 2 isoform X1 [KO:K06065]

CIR1; corepressor interacting with RBPJ 1 [KO:K06066]

LOW QUALITY PROTEIN: corepressor interacting with RBPJ 1-like [KO:K06066]

SPEN; msx2-interacting protein isoform X3 [KO:K25100]

HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]

HDAC1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]

LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]

ATXN1L; ataxin-1-like [KO:K23616]

ATXN1; ataxin-1 isoform X1 [KO:K23616]

Compound

Notch intracellular domain

Reference

Authors

Hansson EM, Lendahl U, Chapman G.

Title

Notch signaling in development and disease.

Journal

Semin Cancer Biol 14:320-8 (2004)
DOI:10.1016/j.semcancer.2004.04.011

Reference

Authors

Callahan R, Egan SE.

Title

Notch signaling in mammary development and oncogenesis.

Journal

J Mammary Gland Biol Neoplasia 9:145-63 (2004)
DOI:10.1023/B:JOMG.0000037159.63644.81

Reference

Authors

Zweidler-McKay PA, Pear WS.

Title

Notch and T cell malignancy.

Journal

Semin Cancer Biol 14:329-40 (2004)
DOI:10.1016/j.semcancer.2004.04.012

Reference

Authors

Wu L, Griffin JD.

Title

Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis.

Journal

Semin Cancer Biol 14:348-56 (2004)
DOI:10.1016/j.semcancer.2004.04.014

Reference

Authors

Tsukumo S, Yasutomo K.

Title

Notch governing mature T cell differentiation.

Journal

J Immunol 173:7109-13 (2004)
DOI:10.4049/jimmunol.173.12.7109

Reference

Authors

Haltiwanger RS.

Title

Regulation of signal transduction pathways in development by glycosylation.

Journal

Curr Opin Struct Biol 12:593-8 (2002)
DOI:10.1016/S0959-440X(02)00371-8

Reference

Authors

Koo EH, Kopan R.

Title

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

Journal

Nat Med 10 Suppl:S26-33 (2004)
DOI:10.1038/nm1065

Reference

Authors

Okano H, Imai T, Okabe M.

Title

Musashi: a translational regulator of cell fate.

Journal

J Cell Sci 115:1355-9 (2002)

Reference

Authors

Haltiwanger RS, Stanley P.

Title

Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.

Journal

Biochim Biophys Acta 1573:328-35 (2002)
DOI:10.1016/S0304-4165(02)00400-2

Reference

Authors

Das G, Reynolds-Kenneally J, Mlodzik M.

Title

The atypical cadherin Flamingo links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye.

Journal

Dev Cell 2:655-66 (2002)
DOI:10.1016/S1534-5807(02)00147-8

Reference

Authors

Cooper MT, Bray SJ.

Title

Frizzled regulation of Notch signalling polarizes cell fate in the Drosophila eye.

Journal

Nature 397:526-30 (1999)
DOI:10.1038/17395

Reference

Authors

Tanigaki K, Kuroda K, Han H, Honjo T.

Title

Regulation of B cell development by Notch/RBP-J signaling.

Journal

Semin Immunol 15:113-9 (2003)
DOI:10.1016/S1044-5323(03)00008-3

Related
pathway

MAPK signaling pathway

KO pathway

LinkDB

DBGET integrated database retrieval system