KEGG ORTHOLOGY: K25100

ORTHOLOGY: K25100

Entry

K25100                      KO

Symbol

SPEN, SHARP, MINT

Name

Msx2-interacting protein

Pathway

map04330

Notch signaling pathway

Disease

H02612

Radio-Tartaglia syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K25100  SPEN, SHARP, MINT; Msx2-interacting protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K25100  SPEN, SHARP, MINT; Msx2-interacting protein
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   Other histone modification proteins
    K25100  SPEN, SHARP, MINT; Msx2-interacting protein

Genes

HSA:	23013(SPEN)

PTR:	456468(SPEN)

PPS:	100988620(SPEN)

GGO:	101133199(SPEN)

PON:	100455472(SPEN)

NLE:	100593189(SPEN)

HMH:	116812968(SPEN)

MCC:	696205(SPEN)

MCF:	102118022(SPEN)

MTHB:

126953866

MNI:	105473221(SPEN)

CSAB:

103225538(SPEN)

CATY:

105599431(SPEN)

PANU:

101018005(SPEN)

TGE:	112618950(SPEN)

MLEU:

105549425(SPEN)

RRO:	104668147(SPEN)

RBB:	108524261(SPEN)

TFN:	117093242(SPEN)

PTEH:

111527290(SPEN)

CANG:

105510262(SPEN)

CJC:	100397407(SPEN)

SBQ:	101044540(SPEN)

CIMI:

108286991

CSYR:

103260425(SPEN)

MMUR:

105870451(SPEN)

LCAT:

123635948(SPEN)

PCOQ:

105824949(SPEN)

OGA:	100943191(SPEN)

MMU:	56381(Spen)

MCAL:

110292742(Spen)

MPAH:

110323944(Spen)

RNO:	690911(Spen)

MCOC:

116096959(Spen)

ANU:	117709301(Spen)

MUN:	110544981(Spen)

CGE:	100754338(Spen)

MAUA:

101842374(Spen)

PROB:

127213254(Spen)

PLEU:

114700869(Spen)

MORG:

121448059(Spen)

MFOT:

126507498

AAMP:

119816388(Spen)

NGI:	103725328(Spen)

HGL:	101710447(Spen)

CPOC:

100713290(Spen)

CCAN:

109692559(Spen)

DORD:

105989955(Spen)

DSP:	122099164(Spen)

PLOP:

125354612(Spen)

NCAR:

124965244

MMMA:

107141587(Spen)

OCU:

100348281

OPI:	101524815(SPEN)

TUP:	102490558(SPEN)

GVR:	103581850 103604260(SPEN)

CFA:	100687765(SPEN)

CLUD:

112659931(SPEN)

VVP:	112929779(SPEN)

VLG:	121497893(SPEN)

NPO:	129514022(SPEN)

AML:	100479487(SPEN)

UMR:	103666839(SPEN)

UAH:	113270463(SPEN)

UAR:	123777798(SPEN)

ELK:

111154596

LLV:

125096716

MPUF:

101677334(SPEN)

MNP:	132001594(SPEN)

MLK:	131809729(SPEN)

NVS:	122899486(SPEN)

ORO:	101384878(SPEN)

EJU:	114213224(SPEN)

ZCA:	113931781(SPEN)

MLX:	118019967(SPEN)

NSU:	110575139(SPEN)

LWW:

102726775

FCA:	101082674(SPEN)

PYU:	121021643(SPEN)

PCOO:

112848583(SPEN)

PBG:	122479974(SPEN)

PVIV:

125172934(SPEN)

LRUF:

124514672

PTG:	102965886(SPEN)

PPAD:

109274165(SPEN)

PUC:

125913060

AJU:

106975578

HHV:	120229779(SPEN)

BTA:	513692(SPEN)

BOM:	102267558(SPEN)

BIU:	109570297(SPEN)

BBUB:

102396070(SPEN)

BBIS:

104996108(SPEN)

CHX:	102170255(SPEN)

OAS:	101108848(SPEN)

BTAX:

128061233(SPEN)

ODA:	120880594(SPEN)

CCAD:

122452356(SPEN)

MBEZ:

129551387(SPEN)

SSC:	100620266(SPEN)

CFR:	102521677(SPEN)

CBAI:

105070936(SPEN)

CDK:	105107066(SPEN)

VPC:	102538278(SPEN)

BACU:

103006082(SPEN)

BMUS:

118894897(SPEN)

LVE:	103083686(SPEN)

OOR:	101274268(SPEN)

DLE:	111187190(SPEN)

PCAD:

102993961(SPEN)

PSIU:

116763253(SPEN)

NASI:

112402663(SPEN)

ECB:	100053790(SPEN)

EPZ:	103552937(SPEN)

EAI:	106827998(SPEN)

MYB:	102251600(SPEN)

MYD:	102757430(SPEN)

MMYO:

118676018(SPEN)

MLF:	102431643(SPEN)

PKL:	118723678(SPEN)

EFUS:

103292024(SPEN)

MNA:	107541914(SPEN)

DRO:	112299132(SPEN)

SHON:

118986309(SPEN)

AJM:	119049955(SPEN)

PDIC:

114496132(SPEN)

PHAS:

123832337(SPEN)

MMF:	118626581(SPEN)

PPAM:

129075631(SPEN)

HAI:	109389398(SPEN)

RFQ:	117027148(SPEN)

PALE:

102898186(SPEN)

PGIG:

120585769(SPEN)

PVP:	105294409(SPEN)

RAY:	107501794(SPEN)

MJV:	108400531(SPEN)

TOD:	119236049(SPEN)

SARA:

101551010(SPEN)

SETR:

126006503(SPEN)

LAV:	100654888(SPEN)

TMU:

101356382

ETF:	101659114(SPEN)

DNM:	101427827(SPEN)

MDO:	100017979(SPEN)

GAS:	123240336(SPEN)

SHR:	100928630(SPEN)

AFZ:

127555823

PCW:	110198727(SPEN)

OAA:	107548073(SPEN)

GGA:	419460(SPEN)

PCOC:

116242523(SPEN)

MGP:	104914213(SPEN)

CJO:	107323312(SPEN)

TPAI:

128085078(SPEN)

LMUT:

125703239(SPEN)

NMEL:

110408516(SPEN)

APLA:

101792876(SPEN)

ACYG:

106040194(SPEN)

CATA:

118258831(SPEN)

AFUL:

116497487(SPEN)

TGU:	100218772(SPEN)

LSR:	110474450(SPEN)

SCAN:

103820969(SPEN)

PMOA:

120496793(SPEN)

OTC:	121343883(SPEN)

PRUF:

121351417(SPEN)

GFR:	102035811(SPEN)

FAB:	101816324(SPEN)

OMA:

130266705

PHI:	102106003(SPEN)

PMAJ:

107213537(SPEN)

CCAE:

111938560(SPEN)

CCW:	104698596(SPEN)

CBRC:

103614543(SPEN)

ETL:	114068924(SPEN)

ZAB:	102068057(SPEN)

ACHL:

103801153(SPEN)

SVG:	106860512(SPEN)

MMEA:

130581862(SPEN)

HRT:	120762412(SPEN)

FPG:	101919513(SPEN)

FCH:	102053517(SPEN)

CLV:	102097771(SPEN)

EGZ:	104133188(SPEN)

NNI:	104011237(SPEN)

PCRI:

104033433

PLET:

104616837(SPEN)

EHS:

104507016

PCAO:

104052405

ACUN:

113487954(SPEN)

TALA:

104367092(SPEN)

PADL:

103922245(SPEN)

AFOR:

103907404(SPEN)

ACHC:

115343339(SPEN)

HALD:

104319126

HLE:	104837829(SPEN)

AGEN:

GCL:

CCRI:

CMAC:

MUI:	104544133(SPEN)

BREG:

104637320

FGA:

104075623

GSTE:

104262600(SPEN)

LDI:	104353350(SPEN)

MNB:	103775619(SPEN)

OHA:	104326544(SPEN)

NNT:

104406334

SHAB:

115617431(SPEN)

DPUB:

104309962(SPEN)

PGUU:

104467802

ACAR:

104523316

CPEA:

104387083(SPEN)

AVIT:

104276047

CVF:	104295618(SPEN)

RTD:	128918431(SPEN)

CUCA:

104055144(SPEN)

TEO:

104377459

BRHI:

104495553

AAM:	106491392(SPEN)

AROW:

112977485(SPEN)

NPD:	112959537(SPEN)

TGT:	104570496(SPEN)

DNE:	112993478(SPEN)

SCAM:

104141597(SPEN)

ASN:	102368941(SPEN)

AMJ:	102573903(SPEN)

CPOO:

109314321(SPEN)

GGN:	109293848(SPEN)

PSS:	102445755(SPEN)

CMY:	102938075(SPEN)

CCAY:

125624559(SPEN)

DCC:	119845240(SPEN)

CPIC:

101947057(SPEN)

TST:	117867911(SPEN)

CABI:

116829020(SPEN)

MRV:	120387817(SPEN)

ACS:	100557393(spen)

ASAO:

132764783(SPEN)

PVT:	110073167(SPEN)

SUND:

121936104(SPEN)

PBI:	103057302(SPEN)

PMUR:

107296437(SPEN)

CTIG:

120319145(SPEN)

TSR:	106543170(SPEN)

PGUT:

117654721(SPEN)

APRI:

131187230(SPEN)

PTEX:

113446293(SPEN)

NSS:	113423130(SPEN)

VKO:	123018819(SPEN)

PMUA:

114602783(SPEN)

PRAF:

128419892(SPEN)

ZVI:	118087589(SPEN)

HCG:	128338678(SPEN)

GJA:	107111598(SPEN)

STOW:

125445472(SPEN)

EMC:	129344588(SPEN)

XLA:	108696848 108697856

XTR:	549816(spen)

NPR:	108802490(SPEN)

RTEM:

120915909(SPEN)

BBUF:

120994632(SPEN)

BGAR:

122929043(SPEN)

MUO:	115456846(SPEN)

GSH:	117348818(SPEN)

DRE:	322667(wu:fb69f10) 503940(spen)

SRX:	107716126 107719036 107737932

SANH:

107681326 107687431 107690549(spen)

SGH:	107571566 107573135 107593929

CCAR:

109071183 109102755

CAUA:

113039319 113045596(spen) 113068916 113076624 113102974

CGIB:

127942560(si:ch1073-335m2.2) 127945008 127987554 128011993

PTET:

122327902(si:ch1073-335m2.2) 122328335(spen)

LROH:

127155229(spen) 127157388(si:ch1073-335m2.2)

OMC:	131531194(si:ch1073-335m2.2) 131532700(spen)

PPRM:

120462912(spen) 120486460(si:ch1073-335m2.2)

RKG:	130072728(si:ch1073-335m2.2) 130102171(spen)

MAMB:

125260157(spen) 125263146(si:ch1073-335m2.2)

CIDE:

127521330(si:ch1073-335m2.2)

MASI:

127419125 127420070 127438025 127439109

TROS:

130549181(si:ch1073-335m2.2) 130571838(spen)

TDW:	130408856(spen) 130429436(si:ch1073-335m2.2)

MANU:

129431209(spen) 129453213(si:ch1073-335m2.2)

IPU:	108254705(si:ch1073-335m2.2) 108275899

IFU:	128619155(spen) 128624885(si:ch1073-335m2.2)

PHYP:

113530460(spen) 113539745

SMEO:

124402138(si:ch1073-335m2.2)

TFD:	113637000(si:ch1073-335m2.2) 113658181(spen)

TVC:	132838268(si:ch1073-335m2.2) 132861874(spen)

AMEX:

103025061(spen) 103039842

CMAO:

118799765(si:ch1073-335m2.2) 118821944(spen)

EEE:	113580150(spen) 113582791

CHAR:

105899022(spen) 105904994 122132894(si:ch1073-335m2.2)

TRU:	101067722 101069501

TFS:	130523830(si:ch1073-335m2.2) 130529611(spen)

TNG:	GSTEN00027360G001

LCO:	104921449(spen) 104933306

NCC:	104949008 104966852(spen)

TBEN:

117489970(si:ch1073-335m2.2) 117494255(spen)

CGOB:

115008019 115010447(spen)

PGEO:

117446308(si:ch1073-335m2.2) 117449101(spen)

GACU:

117540347(spen) 117551140(si:ch1073-335m2.2)

EMAC:

134865576(spen) 134882507(si:ch1073-335m2.2)

ELY:	117256187(si:ch1073-335m2.2) 117257803(spen)

EFO:	125888593(si:ch1073-335m2.2) 125891233(spen)

PLEP:

121947451(spen) 121956541(si:ch1073-335m2.2)

SLUC:

116041008(spen) 116041534(si:ch1073-335m2.2)

ECRA:

117943241(si:ch1073-335m2.2) 117947526(spen)

ESP:	116687668 116692301(spen)

PFLV:

114553841 114558125(spen)

GAT:	120829297(spen) 120835233(si:ch1073-335m2.2)

PPUG:

119193898(si:ch1073-335m2.2) 119223761(spen)

AFB:	129099464(spen) 129105447(si:ch1073-335m2.2)

CLUM:

117730649(si:ch1073-335m2.2) 117733195(spen)

PSWI:

130199590(spen) 130208120(si:ch1073-335m2.2)

MSAM:

119886194(si:ch1073-335m2.2) 119903268 119905885(spen)

SCHU:

122882835(spen) 122884188(si:ch1073-335m2.2)

CUD:	121506284(si:ch1073-335m2.2) 121517056(spen)

ALAT:

119020798(si:ch1073-335m2.2) 119022172(spen)

MZE:	101483752 101488079

ONL:	100703921(spen) 100709408

OAU:	116324469(spen) 116333890(si:ch1073-335m2.2)

OLA:	101159000 101160467(spen)

OML:	112138517(spen) 112144510(si:ch1073-335m2.2)

CSAI:

133448524(si:ch1073-335m2.2) 133457414(spen)

XMA:	102232126 102234793(spen)

XCO:	114135202 114149003(spen)

XHE:	116710346 116724720(spen)

PRET:

103465147 103467027(spen)

PFOR:

103130289 103150457(spen)

PLAI:

106935897(spen) 106960335

PMEI:

106905196(spen) 106929628

GAF:	122829650(spen) 122833901(si:ch1073-335m2.2)

PPRL:

129356165(si:ch1073-335m2.2) 129371680(spen)

CVG:	107099940(spen) 107103107

CTUL:

119780036(si:ch1073-335m2.2) 119792050(spen)

GMU:	124857317(si:ch1073-335m2.2) 124869580(spen)

NFU:	107390337(spen) 107395123

KMR:	108233062(spen) 108235702(si:ch1073-335m2.2)

ALIM:

106516166 106518933

NWH:	119411911(si:ch1073-335m2.2) 119417719(spen)

AOCE:

111564731(spen) 111574341

MCEP:

125007805(speN)

CSEM:

103384781(spen) 103385858

POV:	109630776(spen) 109638551

SSEN:

122768241(si:ch1073-335m2.2) 122777387(spen)

HHIP:

117761771(si:ch1073-335m2.2) 117764328(spen)

HSP:	118104490(si:ch1073-335m2.2) 118110800(spen)

SMAU:

118309249(si:ch1073-335m2.2) 118316495(spen)

LCF:	108882590 108886505(si:ch1073-335m2.2)

SDU:	111222065 111227599(spen)

SLAL:

111656206(spen)

XGL:	120783466(si:ch1073-335m2.2) 120803531(spen)

HCQ:	109522309 109528486(spen)

SSCV:

125977226(si:ch1073-335m2.2) 125988180

SBIA:

133496978(spen) 133507358(si:ch1073-335m2.2)

PEE:	133408891(si:ch1073-335m2.2) 133412870(spen)

PTAO:

133484230(si:ch1073-335m2.2) 133484706(spen)

BPEC:

110158104 110168698

MALB:

109964454 109967192(spen)

BSPL:

114855805(si:ch1073-335m2.2) 114858977(spen)

SJO:	128356169(si:ch1073-335m2.2) 128356860(spen)

SASA:

106565133 106566857 106572016 106583464

STRU:

115150257 115165874 115168210 115208173

OTW:	112216088 112222020(spen) 112244802(si:ch1073-335m2.2) 112254872

OMY:	110492244(spen) 110494951 110528407 110532368

OGO:	124002906 124028447 124032006 124045817(spen)

ONE:	115102255 115132237 115142900 115142935

OKI:	109869420 109891332 109892849 109908062

OKE:	118359778(spen) 118360953 118374137 118388866(si:ch1073-335m2.2)

SALP:

111962319 111966531 111970377 111977124(spen)

SNH:	120021773 120059287 120061593(spen) 120064819

CCLU:

121538424 121545565(spen) 121575419 121578078

ELS:	105016849(spen)

SFM:	108928199 108933902

PKI:	111853338 111853890

AANG:

118207523(spen) 118210530

LOC:	102686502(spen)

PSPA:

121328693 121328714

ARUT:

117425306 117432104

PSEX:

120530825(spen)

LCM:	102352673(SPEN)

CMK:	103187454(spen)

RTP:

109926950

CPLA:

122540264(spen)

HOC:	132833651(spen)

LERI:

129711488(spen)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG18497(spen)

DER:

6540971

DSE:

6617215

DSI:	Dsimw501_GD23007(Dsim_GD23007)

DYA:	Dyak_GE16637

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17029

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ003108

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207370

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:	103520256 113467164

CLEC:

106674369

HHAL:

106687753

NLU:

111052521

PHU:	Phum_PHUM127440

FOC:

TPAL:

ZNE:

CSEC:

FCD:

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

OBI:	106872232 128250889

OSN:

115224839

SMM:	Smp_048160

SHX:	MS3_00001938

OVI:	T265_10768

EGL:

NVE:

EPA:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:11331609

Authors

Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM

Title

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.

Journal

Genes Dev 15:1140-51 (2001)
DOI:10.1101/gad.871201

Sequence

[hsa:23013]

LinkDB

DBGET integrated database retrieval system