KEGG ORTHOLOGY: K04522

ORTHOLOGY: K04522

Entry

K04522                      KO

Symbol

PSEN2, PS2

Name

presenilin 2 [EC:3.4.23.-]

Pathway

map04330

Notch signaling pathway

map04722

Neurotrophin signaling pathway

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Disease

H00056

Alzheimer disease

H00294

Dilated cardiomyopathy

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K04522  PSEN2, PS2; presenilin 2
09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04522  PSEN2, PS2; presenilin 2
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04522  PSEN2, PS2; presenilin 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04522  PSEN2, PS2; presenilin 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04522  PSEN2, PS2; presenilin 2
Peptidases and inhibitors [BR:ko01002]
Aspartic peptidases
  Family A22: presenilin family
   K04522  PSEN2, PS2; presenilin 2

Other DBs

GO:

0042500

TC:	1.A.54.1.2

Genes

HSA:	5664(PSEN2)

PTR:	457790(PSEN2)

PPS:	100975191(PSEN2)

GGO:	101137786(PSEN2)

PON:	100172138(PSEN2)

PPYG:

129021880(PSEN2)

NLE:	100596029(PSEN2)

HMH:	116457564(PSEN2)

SSYN:

129458425(PSEN2)

MCC:	698770(PSEN2)

MCF:	102117766(PSEN2)

MTHB:

126935884

MNI:	105478639(PSEN2)

CSAB:

103229985(PSEN2)

CATY:

105576920(PSEN2)

PANU:

101005201(PSEN2)

TGE:	112610462(PSEN2)

MLEU:

105536583(PSEN2)

RRO:	104677021(PSEN2)

RBB:	108535935(PSEN2)

TFN:	117074640(PSEN2)

PTEH:

111537068(PSEN2)

CANG:

105516694(PSEN2)

CJC:	100399890(PSEN2)

SBQ:	101051940(PSEN2)

CIMI:

108302749(PSEN2)

ANAN:

105722330(PSEN2)

CSYR:

103271842(PSEN2)

MMUR:

105863820(PSEN2)

LCAT:

123627539(PSEN2)

ERUF:

138393389(PSEN2)

PCOQ:

105810413(PSEN2)

OGA:	100958952(PSEN2)

MMU:	19165(Psen2)

MCAL:

110298007(Psen2)

MPAH:

110321711(Psen2)

RNO:	81751(Psen2)

MCOC:

116104626(Psen2)

ANU:	117721886(Psen2)

ASYL:

127697280(Psen2)

MUN:	110559485(Psen2)

CGE:	100752237(Psen2)

MAUA:

101835004(Psen2)

PROB:

127223694(Psen2)

PLEU:

114690634(Psen2)

PMAV:

102906989(Psen2)

MORG:

121435835(Psen2)

MFOT:

126502217

AAMP:

119827510(Psen2)

CNL:	130875086(Psen2)

NGI:	103725095(Psen2)

HGL:	101705181(Psen2)

CPOC:

100717114(Psen2)

CCAN:

109690752(Psen2)

DORD:

105986552(Psen2)

DSP:	122126773(Psen2)

DMER:

138827594(Psen2)

PLOP:

125345234 125359911(Psen2)

NCAR:

124962040

MMMA:

107140486(Psen2)

ITI:	101965730(Psen2)

OCU:

100343671

OPI:	101521444(PSEN2)

OCZ:	121148234(PSEN2)

TUP:	102490523(PSEN2)

GVR:	103600283(PSEN2)

CFA:	490382(PSEN2)

CLUD:

112648798(PSEN2)

VVP:	112923553(PSEN2)

VLG:	121499842(PSEN2)

NPO:	129509080(PSEN2)

AML:	100466510(PSEN2)

UMR:	103667043(PSEN2)

UAH:	113262931(PSEN2)

UAR:	123791662(PSEN2)

ELK:

111150660

LLV:

125085890

MPUF:

101693386(PSEN2)

MNP:	132025399(PSEN2)

MLK:	131814549(PSEN2)

NVS:	122918545(PSEN2)

ORO:	101371937(PSEN2)

EJU:	114215772(PSEN2)

ZCA:	113933533(PSEN2)

MLX:	118014577(PSEN2)

MANO:

123846321(PSEN2)

NSU:	110580209(PSEN2)

LWW:

102747561

FCA:	101081693(PSEN2)

PYU:

121024701

PCOO:

112863137(PSEN2)

PBG:	122476485(PSEN2)

PVIV:

125155626(PSEN2)

LRUF:

124510287

LGF:	123585263(PSEN2)

AJU:

106968626

PTG:	102972248(PSEN2)

PPAD:

109250950(PSEN2)

PUC:

125925871

PLEZ:

122211919(PSEN2)

HHV:	120234142(PSEN2)

CCRU:

144244521(PSEN2)

BTA:	282010(PSEN2)

BOM:	102284134(PSEN2)

BIU:	109570674(PSEN2)

BBUB:

102402822(PSEN2)

BKE:	129652924(PSEN2)

BBIS:

104997905(PSEN2)

CHX:	102190980(PSEN2)

OAS:	101113776(PSEN2)

BTAX:

128061239(PSEN2)

CSUM:

138090184(PSEN2)

ODA:	120880328(PSEN2)

CCAD:

122452101(PSEN2)

MREE:

136168291(PSEN2)

OVR:	110151813(PSEN2)

MBEZ:

129551626(PSEN2)

SSC:	780410(PSEN2)

CFR:	102516800(PSEN2)

CBAI:

105083776(PSEN2)

CDK:	105099573(PSEN2)

VPC:	102524839(PSEN2)

BACU:

102998556(PSEN2)

BMUS:

118902664(PSEN2)

OOR:	101284327(PSEN2)

LALB:

132508189(PSEN2)

GMF:	115859481(PSEN2)

DDP:	132414610(PSEN2)

DLE:	111177533(PSEN2)

PCAD:

102973884(PSEN2)

PSIU:

116758258(PSEN2)

PPHC:

136120005(PSEN2)

NASI:

112395675(PSEN2)

ECB:	100054506(PSEN2)

EPZ:	103558515(PSEN2)

EAI:	106846370(PSEN2)

MYB:	102242706(PSEN2)

MYD:	102772354(PSEN2)

MMYO:

118678803(PSEN2)

MLF:

102427086

MDT:	132222537(PSEN2)

MYUM:

138999103(PSEN2)

PKL:	118727734(PSEN2)

EFUS:

103301080(PSEN2)

MNA:	107528344(PSEN2)

DRO:	112318833(PSEN2)

SHON:

119003167(PSEN2)

AJM:	119044458(PSEN2)

PDIC:

114512279(PSEN2)

PHAS:

123805170(PSEN2)

MMF:	118640601(PSEN2)

PPAM:

129073012(PSEN2)

HAI:	109391446(PSEN2)

RFQ:	117018604(PSEN2)

PALE:

102888829(PSEN2)

PGIG:

120619111(PSEN2)

PVP:	105292607(PSEN2)

RAY:	107517103(PSEN2)

MJV:	108396215(PSEN2)

TOD:	119244553(PSEN2)

SARA:

101538877(PSEN2)

SFUM:

130039842(PSEN2)

SETR:

126003809 126013418(PSEN2)

LAV:	100660389(PSEN2)

TMU:

101356799

ETF:	101660961(PSEN2)

DNM:

101411493

MDO:	100026453(PSEN2)

GAS:	123247789(PSEN2)

SHR:	100928719(PSEN2)

AFZ:

127559553

PCW:	110205512(PSEN2)

TVP:	118848403(PSEN2)

PBRV:

138146977(PSEN2)

MLAO:

141513213(PSEN2)

OAA:	100076299(PSEN2)

TACU:

119940863(PSEN2)

GGA:	374188(PSEN2)

PCOC:

116232172(PSEN2)

MGP:	100547513(PSEN2)

CJO:	107310896(PSEN2)

TPAI:

128082769(PSEN2)

LMUT:

125689526(PSEN2)

NMEL:

110395322(PSEN2)

APLA:

101791857(PSEN2)

AACU:

137853501(PSEN2)

OJA:	118164307(PSEN2)

ACYG:

106031593(PSEN2)

CATA:

118257169(PSEN2)

AFUL:

116487655(PSEN2)

TGU:	100232599(PSEN2)

LSR:	110473970(PSEN2)

SCAN:

103821306(PSEN2)

PMOA:

120506001(PSEN2)

OTC:	121346932(PSEN2)

PRUF:

121357068(PSEN2)

ATRC:

139587384(PSEN2)

GFR:	102040969(PSEN2)

FAB:	101821118(PSEN2)

OMA:	130250919(PSEN2)

PHI:	102107717(PSEN2)

PMAJ:

107201877(PSEN2)

CCAE:

111926282(PSEN2)

CCW:	104685571(PSEN2)

CBRC:

103612685(PSEN2)

ACOE:

138107725(PSEN2)

ETL:	114073549(PSEN2)

ZAB:	102068930(PSEN2)

ZLE:	135446072(PSEN2)

ACHL:

103798461(PSEN2)

SVG:	106853887(PSEN2)

MMEA:

130578655(PSEN2)

HRT:	120750090(PSEN2)

SATI:

136359569(PSEN2)

CFAI:

136286504(PSEN2)

CCIC:

134042719(PSEN2)

FPG:	101914026(PSEN2)

FCH:	102052189(PSEN2)

CCRI:

104164712(PSEN2)

NNT:	104404102(PSEN2)

SHAB:

115613991(PSEN2)

ACUN:

113478947(PSEN2)

ANOC:

141956530(PSEN2)

SURA:

141941334(PSEN2)

TALA:

104366618(PSEN2)

ACHC:

115350048(PSEN2)

HALD:

104321008(PSEN2)

HLE:	104838151(PSEN2)

AGEN:

126052659

HHAR:

128150538(PSEN2)

BBUT:

142037865(PSEN2)

GCL:

127015340

CSTI:

104550545(PSEN2)

LDI:	104351612(PSEN2)

MNB:	103772536(PSEN2)

DPUB:

104303233

PPUS:

135186714(PSEN2)

AVIT:

104268061(PSEN2)

BRHI:

104497902(PSEN2)

EGZ:	104134612(PSEN2)

NNI:	104019271(PSEN2)

PCRI:

104025634(PSEN2)

PCAO:

104053903(PSEN2)

PARX:

142055160(PSEN2)

PADL:

103925007(PSEN2)

AFOR:

103904173(PSEN2)

FGA:	104070958(PSEN2)

CBOR:

142080957(PSEN2)

GSTE:

104251611(PSEN2)

CBOY:

140649609(PSEN2)

MAME:

142407265(PSEN2)

CLV:	102086670(PSEN2)

CNIC:

135987449(PSEN2)

MUI:	104537208(PSEN2)

PGUU:

104463825(PSEN2)

PLET:

104624415(PSEN2)

EHS:	104503401(PSEN2)

CMAC:

104485250(PSEN2)

CUCA:

104067041(PSEN2)

TEO:	104370517(PSEN2)

BREG:

104629946(PSEN2)

GAME:

129204615(PSEN2)

OHA:	104331959(PSEN2)

ACAR:

104530118(PSEN2)

CPEA:

104386211(PSEN2)

CVF:	104283586(PSEN2)

RTD:	128906681(PSEN2)

CRID:

134512639(PSEN2)

LMIC:

141740373(PSEN2)

NARQ:

141476231(PSEN2)

AAM:	106482720(PSEN2)

AROW:

112963409(PSEN2)

NPD:	112954816(PSEN2)

TGT:	104570942(PSEN2)

DNE:	112980049(PSEN2)

SCAM:

104151492(PSEN2)

ASN:	102387066(PSEN2)

AMJ:	102572042(PSEN2)

CPOO:

109319789(PSEN2)

GGN:	109296911(PSEN2)

PSS:	102444598(PSEN2)

CIZ:	142011047(PSEN2)

CMY:	102932404(PSEN2)

CCAY:

125633704(PSEN2)

LKP:	140909427(PSEN2)

NDS:	141985235(PSEN2)

DCC:	119852555(PSEN2)

CPIC:

101931945(PSEN2)

TST:	117874520(PSEN2)

EOB:	135875530(PSEN2)

CABI:

116835398(PSEN2)

MRV:	120401994(PSEN2)

ACS:	100567182(psen2)

ASAO:

132761361(PSEN2)

PVT:	110087560(PSEN2)

SUND:

121914770(PSEN2)

PBI:	103051424(PSEN2)

PMUR:

107291203(PSEN2)

CTIG:

120307236(PSEN2)

TSR:	106538735(PSEN2)

PGUT:

117671777(PSEN2)

PCAE:

139321000(PSEN2)

APRI:

131190267(PSEN2)

PTEX:

113433217(PSEN2)

NSS:	113421528(PSEN2)

VKO:	123026669(PSEN2)

PMUA:

114594604(PSEN2)

PRAF:

128411053(PSEN2)

ZVI:	118083232(PSEN2)

HCG:	128349884(PSEN2)

GJA:	107118519(PSEN2)

STOW:

125439150(PSEN2)

EMC:	129330706(PSEN2) 129336286

XLA:	108716701(psen2.L) 397713(psen2.S)

XTR:	549935(psen2)

NPR:

108789850

RTEM:

120937579(PSEN2)

ACAT:

PADS:

BBUF:

BGAR:

DTC:

HSQ:

PCOB:

134910112(PSEN2)

PWL:	138296129(PSEN2)

MUO:

115465463

GSH:

117357614

DRE:	58026(psen2)

SRX:	107747431 107757025

SANH:

107675694 107684264

SGH:	107594418(psen2)

CCAR:

109107333(psen2)

CAUA:

113044005 113044116 113047188

CGIB:

127949017 128020920

PTET:

122345648(psen2)

LROH:

127167920(psen2)

GRF:	141337077(psen2)

OMC:	131544514(psen2)

RKG:	130087332(psen2)

MAMB:

125271909(psen2)

CIDE:

127521384

CERY:

137033122(psen2)

MASI:

127444057 127445261

TROS:

130552956(psen2)

TDW:	130434834(psen2)

MANU:

129444103(psen2)

PDAB:

135785785(psen2)

IPU:	108258586(psen2)

IFU:	128601862(psen2)

PHYP:

113537368

SMEO:

124378381(psen2)

TFD:	113663591(psen2)

TVC:	132839864(psen2)

CGAR:

128506160(psen2)

NGRA:

132866375(psen2)

TRN:	134328753(psen2)

AMEX:

103047139(psen2)

CMAO:

118797883(psen2)

EEE:

113579670

CHAR:

105909396(psen2)

SPIL:

134088273(psen2)

ASAD:

121718608(psen2)

TRU:	101066600(psen2)

TFS:	130527476(psen2)

TNG:	GSTEN00004150G001

LCO:

104939462

TBEN:

117484604(psen2)

CGOB:

115006185

EMAC:

134862752(psen2)

ELY:	117255682(psen2)

EFO:	125885532(psen2)

SLUC:

116048132(psen2)

PFLV:

114568663

GAT:	120824614(psen2)

PPUG:

119218242(psen2)

AFB:	129114751(psen2)

CLUM:

117737420(psen2)

PSWI:

130191381(psen2)

CANA:

137802053(psen2)

CVE:	137866698(psen2)

MSAM:

119899857(psen2)

SCHU:

122873460(psen2)

EARM:

139296013(psen2)

CUD:	121508866(psen2)

SPUL:

138595007(psen2)

LMIX:

132993728(psen2)

HTC:	141807234(psen2)

ALAT:

119023968(psen2)

ASTR:

137599630(psen2)

PKLU:

139199326(psen2)

MZE:

101475262

ONL:

100710620

OAU:	116317828(psen2)

OLA:	101156628(psen2)

OML:	112143463(psen2)

CSAI:

133445986(psen2)

XMA:	102228767(psen2)

XCO:

114144028

XHE:	116720116(psen2)

PRET:

103471903(psen2)

PFOR:

103130109(psen2)

PLAI:

106942401

PMEI:

106910414(psen2)

GAF:	122828944(psen2)

PPRL:

129356020 129356396

CVG:

107104490

CTUL:

119785523(psen2)

GMU:	124868074(psen2)

NFU:	107393984(psen2)

KMR:	108229062(psen2)

ALIM:

106535157

NWH:	119422305(psen2)

AOCE:

111583303(psen2)

EJA:	138209230(psen2)

BFRE:

138634865(psen2)

MCEP:

125004067(psen2)

CSEM:

103383288(psen2)

POV:

109647972

SSEN:

122771274(psen2)

SSOE:

131466682(psen2)

HHIP:

117764153(psen2)

HSP:	118121110(psen2)

PPLT:

128437483(psen2)

SMAU:

118312173(psen2)

LCF:	108882296(psen2)

SDU:	111237573(psen2)

SLAL:

111672890

XGL:	120799864(psen2)

HCQ:	109527634(psen2)

SSCV:

125968505(psen2)

SBIA:

133505670(psen2)

PEE:	133403959(psen2)

PTAO:

133476935(psen2)

BPEC:

110162540

ENY:	140377549(psen2)

MALB:

109971823

BSPL:

114857686(psen2)

SJO:	128378246(psen2)

SSCO:

133999928(psen2)

TTY:	137180425(psen2)

GMH:	115540085(psen2)

SASA:

100194958(psn2) 106586215

STRU:

115178279 115208527

OTW:	112237712 112265587(psen2)

OMY:	110493758(psen2)

OGO:	124004310(psen2)

ONE:	115142639(psen2)

OKI:	109865262 109890007

OKE:	118389133(psen2)

OMM:

OCLA:

SALP:

SNH:

SFON:

129838952(psen2)

CCLU:

121572384 123483080

ELS:

105031436

OEP:	134009106(psen2)

SFM:	108927122(psen2)

PKI:	111835702(psen2)

AANG:

118218390 118219468(psen2)

AROT:

135244546(psen2) 135244732

CCOG:

133118216 133122413(psen2)

LOC:	102692912(psen2)

PSPA:

121316092 121317217

ARUT:

117402569 117411533

PSEX:

120516741(psen2)

LCM:	102353018(PSEN2)

CMK:	103178605(psen2)

RTP:	109912001(psen2)

CPLA:

122542745(psen2)

CPUN:

140464213(psen2)

HOC:	132833793(psen2)

SCAU:

119967715(psen2)

LERI:

129696971(psen2)

HAKA:

140733366(psen2)

PMRN:

LRJ:

CLEP:

LVG:

ARUN:

AAMU:

AFIL:

PFLL:

DCI:

LSM:	121119965(Psn)

TCF:

131886972

PPOI:

119108547

DSV:	119462073 119462187

DALB:

135918629 135919023 135919027

RSAN:

RMP:

VDE:

VJA:

DFR:	124489867 124492835

ABRU:

UDV:

SDM:

LPOL:

PMEO:

PVUL:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

LJP:

MCAZ:

MFOO:

XEN:

HSY:

RES:

TBR:	Tb09.160.3510

TBG:	TbgDal_IX2640

TCR:	503543.10 508277.50

LMA:	LMJF_15_1530

LIF:	LINJ_15_1600

LDO:	LDBPK_151600

LMI:	LMXM_15_1530

LMAT:

92516902(LSCM1_06996)

LBZ:	LBRM_15_1530

LPAN:

LPMP_151490

LOI:	92363158(LSCM4_07329)

LEIS:

94181732(GH5_06424)

LEIN:

94190127(JIQ42_06519)

PHET:

94292214(JKF63_06187)

» show all

Reference

PMID:10497236

Authors

Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C

Title

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

Journal

J Biol Chem 274:28669-73 (1999)
DOI:10.1074/jbc.274.40.28669

Reference

PMID:8618867

Authors

Li J, Ma J, Potter H

Title

Identification and expression analysis of a potential familial Alzheimer disease gene on chromosome 1 related to AD3.

Journal

Proc Natl Acad Sci U S A 92:12180-4 (1995)
DOI:10.1073/pnas.92.26.12180

Sequence

[hsa:5664]

LinkDB

DBGET integrated database retrieval system