KEGG   PATHWAY: oor04980
Entry
oor04980                    Pathway                                
Name
Cobalamin transport and metabolism - Orcinus orca (killer whale)
Class
Organismal Systems; Digestive system
Pathway map
oor04980  Cobalamin transport and metabolism
oor04980

Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101273827  TCN1; transcobalamin-1 [KO:K25741]
101289525  CBLIF; cobalamin binding intrinsic factor [KO:K14615]
101277392  TCN2; transcobalamin-2 isoform X1 [KO:K14619]
101289736  CD320; LOW QUALITY PROTEIN: CD320 antigen [KO:K06734]
101271919  LMBRD1; lysosomal cobalamin transport escort protein LMBD1 isoform X1 [KO:K14617]
101280862  ABCD4; lysosomal cobalamin transporter ABCD4 isoform X3 [KO:K05678] [EC:7.6.2.8]
101274733  MMACHC; cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1 [KO:K14618] [EC:1.16.1.6 2.5.1.151]
101272276  MMADHC; cobalamin trafficking protein CblD [KO:K26006]
101274064  MMAB; corrinoid adenosyltransferase MMAB [KO:K00798] [EC:2.5.1.17]
101289442  MMAA; methylmalonic aciduria type A protein, mitochondrial isoform X1 [KO:K07588] [EC:3.6.5.-]
101271835  MMUT; methylmalonyl-CoA mutase, mitochondrial isoform X1 [KO:K01847] [EC:5.4.99.2]
101285453  MTRR; methionine synthase reductase [KO:K00597] [EC:1.16.1.8]
101274110  MTR; methionine synthase isoform X2 [KO:K00548] [EC:2.1.1.13]
101274503  ZNF76; zinc finger protein 76 isoform X2 [KO:K20828]
101281182  ZNF143; zinc finger protein 143 isoform X4 [KO:K20828]
101282458  HCFC1; host cell factor 1 isoform X7 [KO:K14966]
101281906  THAP11; THAP domain-containing protein 11 [KO:K23211]
101274985  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
101271755  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
101279253  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
125960966  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
oor00270  Cysteine and methionine metabolism
oor00280  Valine, leucine and isoleucine degradation
oor00670  One carbon pool by folate
oor04144  Endocytosis
oor04977  Vitamin digestion and absorption
KO pathway
ko04980   
LinkDB

DBGET integrated database retrieval system