KEGG   PATHWAY: oor04144
Entry
oor04144                    Pathway                                
Name
Endocytosis - Orcinus orca (killer whale)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
oor04144  Endocytosis
oor04144

Other DBs
GO: 0006897
Organism
Orcinus orca (killer whale) [GN:oor]
Gene
101269186  SH3KBP1; SH3 domain-containing kinase-binding protein 1 isoform X7 [KO:K12470]
101269298  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101269400  BIN1; myc box-dependent-interacting protein 1 isoform X15 [KO:K12562]
101269453  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101269459  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101269477  CHMP6; charged multivesicular body protein 6 isoform X1 [KO:K12195]
101269487  STAMBP; STAM-binding protein isoform X1 [KO:K11866] [EC:3.4.19.12]
101269645  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101269708  CYTH2; cytohesin-2 isoform X2 [KO:K18441]
101269825  ACAP2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 isoform X2 [KO:K12489]
101269939  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101269982  RAB11B; ras-related protein Rab-11B [KO:K07905]
101269990  CYTH4; cytohesin-4 isoform X2 [KO:K18441]
101270049  CBL; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
101270206  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
101270289  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101270294  EHD4; EH domain-containing protein 4 [KO:K12477]
101270424  VPS37C; vacuolar protein sorting-associated protein 37C isoform X2 [KO:K12185]
101270482  ARAP1; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
101270504  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101270561  WASHC1; WASH complex subunit 1 isoform X4 [KO:K18461]
101270611  IQSEC2; IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
101270622  SMAP1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
101270655  CHMP1A; charged multivesicular body protein 1a isoform X2 [KO:K12197]
101270842  GRK3; beta-adrenergic receptor kinase 2 isoform X1 [KO:K00910] [EC:2.7.11.15]
101270968  AP2M1; AP-2 complex subunit mu [KO:K11826]
101271035  ARF3; ADP-ribosylation factor 3 [KO:K07938]
101271196  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
101271298  VPS26B; vacuolar protein sorting-associated protein 26B [KO:K18466]
101271351  DNM3; dynamin-3 isoform X6 [KO:K01528] [EC:3.6.5.5]
101271422  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X8 [KO:K13305] [EC:2.3.2.26]
101271424  WASHC3; WASH complex subunit 3 isoform X2 [KO:K18463]
101271436  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X1 [KO:K10591] [EC:2.3.2.26]
101271583  ACAP1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 isoform X2 [KO:K12489]
101271621  EPS15L1; epidermal growth factor receptor substrate 15-like 1 isoform X9 [KO:K12472]
101271672  CBLC; E3 ubiquitin-protein ligase CBL-C [KO:K22518] [EC:2.3.2.27]
101271749  [KO:K06751]
101271802  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758]
101271808  VTA1; vacuolar protein sorting-associated protein VTA1 homolog isoform X1 [KO:K12199]
101271936  SPG21; maspardin isoform X2 [KO:K19367]
101271947  [KO:K02833]
101271954  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101272048  [KO:K04175]
101272056  CHMP4A; charged multivesicular body protein 4a isoform X1 [KO:K12194]
101272068  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
101272172  GBF1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X9 [KO:K18443]
101272210  VPS26A; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
101272299  CXCR2; C-X-C chemokine receptor type 2 isoform X1 [KO:K05050]
101272400  ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [KO:K12492]
101272676  PSD; PH and SEC7 domain-containing protein 1 [KO:K12494]
101272760  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
101272819  SNX32; sorting nexin-32 isoform X1 [KO:K17920]
101272954  HGS; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
101273069  TSG101; tumor susceptibility gene 101 protein isoform X2 [KO:K12183]
101273169  FGFR3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
101273190  ZFYVE27; protrudin isoform X4 [KO:K19368]
101273371  EHD2; EH domain-containing protein 2 isoform X1 [KO:K12469]
101273394  VPS37B; vacuolar protein sorting-associated protein 37B isoform X1 [KO:K12185]
101273438  WIPF3; WAS/WASL-interacting protein family member 3 isoform X1 [KO:K19475]
101273459  IST1; IST1 homolog isoform X2 [KO:K19476]
101273464  ASAP2; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X7 [KO:K12488]
101273527  CYTH3; cytohesin-3 [KO:K18441]
101273686  ASAP1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12488]
101273821  [KO:K07939]
101273830  RHOA; transforming protein RhoA [KO:K04513]
101273864  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
101274048  VPS37A; vacuolar protein sorting-associated protein 37A [KO:K12185]
101274062  AGAP3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X6 [KO:K12491]
101274200  RAB8A; ras-related protein Rab-8A [KO:K07901]
101274345  CHMP7; charged multivesicular body protein 7 [KO:K15053]
101274459  PDCD6IP; programmed cell death 6-interacting protein isoform X2 [KO:K12200]
101274523  [KO:K10364]
101274949  PSD2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
101275059  [KO:K07887]
101275063  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X3 [KO:K00889] [EC:2.7.1.68]
101275089  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
101275337  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
101275398  EGFR; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101275444  GRK1; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
101275474  AGAP1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X11 [KO:K12491]
101275489  WASHC5; WASH complex subunit 5 isoform X1 [KO:K18464]
101275494  GRK5; G protein-coupled receptor kinase 5 isoform X3 [KO:K08291] [EC:2.7.11.16]
101275598  CLTA; clathrin light chain A isoform X4 [KO:K04644]
101275621  ARFGAP3; ADP-ribosylation factor GTPase-activating protein 3 isoform X1 [KO:K12493]
101275717  IL2RA; interleukin-2 receptor subunit alpha isoform X3 [KO:K05068]
101275788  TFRC; transferrin receptor protein 1 isoform X2 [KO:K06503]
101275803  AMPH; amphiphysin isoform X1 [KO:K12562]
101275804  EPN3; epsin-3 [KO:K12471]
101275830  WIPF1; WAS/WASL-interacting protein family member 1 [KO:K19475]
101275882  DNAJC6; putative tyrosine-protein phosphatase auxilin isoform X2 [KO:K09526]
101276066  RBSN; rabenosyn-5 isoform X1 [KO:K12481]
101276373  GIT2; ARF GTPase-activating protein GIT2 isoform X1 [KO:K12487]
101276485  RAB11FIP1; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
101276578  [KO:K06751]
101276718  RUFY2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
101276737  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101276766  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
101276854  [KO:K11826]
101276909  GRK6; G protein-coupled receptor kinase 6 isoform X2 [KO:K08291] [EC:2.7.11.16]
101276956  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
101277026  SH3GL2; endophilin-A1 isoform X2 [KO:K11247]
101277263  ACAP3; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
101277421  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
101277428  SNX5; sorting nexin-5 isoform X5 [KO:K17920]
101277509  AP2S1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
101277553  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101277706  GRK7; rhodopsin kinase GRK7 [KO:K00909] [EC:2.7.11.14]
101277970  ARAP2; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K18440]
101278044  [KO:K07940]
101278046  [KO:K03283]
101278143  RAB11FIP2; rab11 family-interacting protein 2 isoform X1 [KO:K12484]
101278299  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
101278555  PIP5KL1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X2 [KO:K13712] [EC:2.7.1.68]
101278706  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101278816  ITCH; E3 ubiquitin-protein ligase Itchy homolog isoform X1 [KO:K05632] [EC:2.3.2.26]
101278998  IGF2R; cation-independent mannose-6-phosphate receptor [KO:K06564]
101279069  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2 [KO:K00889] [EC:2.7.1.68]
101279155  [KO:K07937]
101279167  SNX4; sorting nexin-4 [KO:K17919]
101279230  [KO:K07939]
101279251  RAB4A; ras-related protein Rab-4A isoform X1 [KO:K07879]
101279258  RAB5C; ras-related protein Rab-5C [KO:K07889]
101279321  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
101279891  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
101279935  SPART; spartin isoform X2 [KO:K19366]
101280087  SH3GL3; endophilin-A3 isoform X6 [KO:K11247]
101280102  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
101280121  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
101280167  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101280193  IQSEC1; IQ motif and SEC7 domain-containing protein 1 isoform X4 [KO:K12495]
101280320  VPS36; vacuolar protein-sorting-associated protein 36 isoform X1 [KO:K12190]
101280384  PSD3; PH and SEC7 domain-containing protein 3 isoform X1 [KO:K12494]
101280391  CAV1; caveolin-1 isoform X3 [KO:K06278]
101280577  CBLB; E3 ubiquitin-protein ligase CBL-B [KO:K22517] [EC:2.3.2.27]
101280775  IQSEC3; IQ motif and SEC7 domain-containing protein 3 isoform X4 [KO:K12495]
101280858  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101280883  VPS28; vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
101280917  [KO:K05754]
101280921  PARD3; partitioning defective 3 homolog isoform X3 [KO:K04237]
101280988  CAV2; caveolin-2 isoform X1 [KO:K12958]
101281081  RAB11FIP3; rab11 family-interacting protein 3 isoform X8 [KO:K12485]
101281122  [KO:K12192]
101281189  [KO:K12197]
101281266  DNM2; dynamin-2 isoform X6 [KO:K23484]
101281378  EHD1; EH domain-containing protein 1 [KO:K12483]
101281493  [KO:K11825]
101281682  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
101281703  CHMP2A; charged multivesicular body protein 2a isoform X2 [KO:K12191]
101281797  WASL; actin nucleation-promoting factor WASL isoform X2 [KO:K23612]
101281818  VPS37D; vacuolar protein sorting-associated protein 37D [KO:K12185]
101281976  IGF1R; insulin-like growth factor 1 receptor isoform X4 [KO:K05087] [EC:2.7.10.1]
101282098  [KO:K05756]
101282193  ARF1; ADP-ribosylation factor 1 [KO:K07937]
101282406  ZFYVE9; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
101282452  SMAP2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
101282686  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
101282705  [KO:K18463]
101282770  [KO:K03283]
101282879  RAB7A; ras-related protein Rab-7a [KO:K07897]
101283102  PML; protein PML isoform X2 [KO:K10054] [EC:2.3.2.-]
101283103  AGAP2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
101283115  [KO:K10364]
101283233  PRKCZ; protein kinase C zeta type isoform X3 [KO:K18952] [EC:2.7.11.13]
101283313  RAB11FIP4; rab11 family-interacting protein 4 isoform X3 [KO:K12485]
101283356  LDLR; low-density lipoprotein receptor isoform X1 [KO:K12473]
101283682  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
101283758  RAB31; ras-related protein Rab-31 isoform X1 [KO:K07891]
101283812  LDLRAP1; low density lipoprotein receptor adapter protein 1 isoform X1 [KO:K12474]
101283817  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
101283820  ARF4; ADP-ribosylation factor 4 [KO:K07939]
101283838  CAPZB; F-actin-capping protein subunit beta isoform X2 [KO:K10365]
101283869  ARFGEF2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 isoform X1 [KO:K18442]
101283887  CLTB; clathrin light chain B isoform X3 [KO:K04645]
101283907  ARF6; ADP-ribosylation factor 6 [KO:K07941]
101284011  ACTR3; actin-related protein 3 [KO:K18584]
101284031  RAB35; ras-related protein Rab-35 isoform X2 [KO:K07876]
101284066  [KO:K03283]
101284082  PLD1; phospholipase D1 isoform X6 [KO:K01115] [EC:3.1.4.4]
101284194  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101284307  EPN2; epsin-2 isoform X1 [KO:K12471]
101284311  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101284315  EHD3; EH domain-containing protein 3 [KO:K12476]
101284316  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
101284341  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101284349  [KO:K03283]
101284727  VPS45; vacuolar protein sorting-associated protein 45 isoform X4 [KO:K12479]
101284779  USP8; ubiquitin carboxyl-terminal hydrolase 8 isoform X2 [KO:K11839] [EC:3.4.19.12]
101284851  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
101284876  WASHC2C; WASH complex subunit 2 isoform X2 [KO:K18462]
101284918  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101284950  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101285012  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
101285126  RAB22A; ras-related protein Rab-22A isoform X1 [KO:K07891]
101285143  RUFY1; RUN and FYVE domain-containing protein 1 isoform X3 [KO:K12482]
101285200  RAB11A; ras-related protein Rab-11A [KO:K07904]
101285283  VPS29; vacuolar protein sorting-associated protein 29 [KO:K18467]
101285361  RNF41; E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
101285456  CAV3; caveolin-3 [KO:K12959]
101285518  WASHC4; WASH complex subunit 4 [KO:K18465]
101285547  [KO:K04678] [EC:2.3.2.26]
101285615  CYTH1; cytohesin-1 isoform X6 [KO:K18441]
101285745  SNF8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
101285870  CHMP5; charged multivesicular body protein 5 [KO:K12198]
101286033  EPS15; epidermal growth factor receptor substrate 15 isoform X2 [KO:K12472]
101286234  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101286301  HRAS; GTPase HRas isoform X2 [KO:K02833]
101286385  SMURF2; E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
101286440  RAB10; ras-related protein Rab-10 [KO:K07903]
101286488  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101286595  ASAP3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12488]
101286614  SNX6; sorting nexin-6 isoform X1 [KO:K17920]
101286640  MVB12A; multivesicular body subunit 12A [KO:K12186]
101286657  VPS25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
101286718  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101286766  VPS35; vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
101286960  MVB12B; multivesicular body subunit 12B isoform X1 [KO:K12186]
101287206  RABEP1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
101287305  [KO:K18463]
101287369  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101287555  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
101287568  SNX12; sorting nexin-12 isoform X1 [KO:K17918]
101287654  ARFGEF1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
101287684  ZFYVE16; zinc finger FYVE domain-containing protein 16 isoform X2 [KO:K04679]
101287805  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
101288074  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
101288165  RAB11FIP5; LOW QUALITY PROTEIN: rab11 family-interacting protein 5 [KO:K12484]
101288239  WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
101288471  SH3GLB2; endophilin-B2 isoform X1 [KO:K21269]
101288617  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
101288686  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
101288724  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101288867  SNX3; sorting nexin-3 isoform X1 [KO:K17918]
101288880  DAB2; disabled homolog 2 isoform X5 [KO:K12475]
101288976  [KO:K10364]
101288977  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101288999  SNX1; sorting nexin-1 isoform X1 [KO:K17917]
101289329  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
101289351  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
101289497  SH3GL1; endophilin-A2 isoform X4 [KO:K11247]
101289648  VPS4A; vacuolar protein sorting-associated protein 4A isoform X3 [KO:K12196]
101289683  WIPF2; WAS/WASL-interacting protein family member 2 isoform X4 [KO:K19475]
101289752  [KO:K18584]
101289888  SMURF1; E3 ubiquitin-protein ligase SMURF1 isoform X5 [KO:K04678] [EC:2.3.2.26]
101289927  EPN1; epsin-1 isoform X1 [KO:K12471]
101290116  SNX2; sorting nexin-2 isoform X1 [KO:K17917]
101290234  [KO:K13649]
101290419  ARFGAP2; ADP-ribosylation factor GTPase-activating protein 2 isoform X2 [KO:K12493]
101290441  PSD4; PH and SEC7 domain-containing protein 4 isoform X1 [KO:K12494]
101290453  EEA1; early endosome antigen 1 isoform X2 [KO:K12478]
101290489  [KO:K13649]
105747697  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
105747803  [KO:K07891]
105748394  [KO:K06751]
117197330  [KO:K05757]
117198748  [KO:K12194]
117201235  [KO:K05757]
125960248  CHMP3; charged multivesicular body protein 3 [KO:K12193]
125961047  [KO:K11839] [EC:3.4.19.12]
125962100  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
125963979  [KO:K03283]
125964001  [KO:K04705]
125965152  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
125965560  [KO:K06751]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
oor04060  Cytokine-cytokine receptor interaction
oor04070  Phosphatidylinositol signaling system
oor04130  SNARE interactions in vesicular transport
oor04142  Lysosome
oor04350  TGF-beta signaling pathway
KO pathway
ko04144   

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