KEGG   PATHWAY: pale03440
Entry
pale03440                   Pathway                                
Name
Homologous recombination - Pteropus alecto (black flying fox)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
pale03440  Homologous recombination
pale03440

Other DBs
GO: 0000724
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102898494  SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X2 [KO:K03111]
102890531  RAD50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
102878053  MRE11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
102881755  NBN; nibrin isoform X1 [KO:K10867]
102898588  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
102895982  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
102893717  BARD1; LOW QUALITY PROTEIN: BRCA1-associated RING domain protein 1 [KO:K10683]
102898606  RBBP8; DNA endonuclease RBBP8 isoform X1 [KO:K20773] [EC:3.1.-.-]
102890464  BRIP1; Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
102887896  TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
102888310  ABRAXAS1; BRCA1-A complex subunit Abraxas 1 isoform X3 [KO:K20774]
102878605  UIMC1; BRCA1-A complex subunit RAP80 isoform X2 [KO:K20775]
102894026  BABAM1; BRISC and BRCA1-A complex member 1 isoform X1 [KO:K20776]
102880922  BABAM2; BRISC and BRCA1-A complex member 2 [KO:K12173]
102897805  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X2 [KO:K11864] [EC:3.4.19.-]
102895844  PALB2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
102896802  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
102881642  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
102893012  SYCP3; synaptonemal complex protein 3 [KO:K19528]
102889870  RPA1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
102883783  RPA2; replication protein A 32 kDa subunit [KO:K10739]
102884493  RPA3; replication protein A 14 kDa subunit isoform X1 [KO:K10740]
102878725  RPA4; LOW QUALITY PROTEIN: replication protein A 30 kDa subunit [KO:K10741]
102894016  RAD51; DNA repair protein RAD51 homolog 1 [KO:K04482]
102880900  RAD52; DNA repair protein RAD52 homolog isoform X1 [KO:K10873]
102895090  RAD51B; DNA repair protein RAD51 homolog 2 isoform X6 [KO:K10869]
102885802  RAD51C; DNA repair protein RAD51 homolog 3 isoform X3 [KO:K10870]
102882022  RAD51D; DNA repair protein RAD51 homolog 4 isoform X3 [KO:K10871]
102888362  XRCC2; DNA repair protein XRCC2 [KO:K10879]
102887560  XRCC3; LOW QUALITY PROTEIN: DNA repair protein XRCC3 [KO:K10880]
102892784  RAD54L; DNA repair and recombination protein RAD54-like isoform X2 [KO:K10875] [EC:5.6.2.-]
102891752  RAD54B; DNA repair and recombination protein RAD54B isoform X2 [KO:K10877] [EC:5.6.2.-]
102896397  POLD1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
102884073  POLD2; DNA polymerase delta subunit 2 [KO:K02328]
102895310  POLD3; DNA polymerase delta subunit 3 [KO:K03504]
102893003  POLD4; DNA polymerase delta subunit 4 [KO:K03505]
102888215  BLM; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
102880328  TOP3B; DNA topoisomerase 3-beta-1 isoform X2 [KO:K03165] [EC:5.6.2.1]
102878631  TOP3A; DNA topoisomerase 3-alpha isoform X1 [KO:K03165] [EC:5.6.2.1]
102885920  MUS81; crossover junction endonuclease MUS81 isoform X7 [KO:K08991] [EC:3.1.22.-]
102887468  EME1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

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