KEGG   PATHWAY: pavi00480
Entry
pavi00480                   Pathway                                
Name
Glutathione metabolism - Prunus avium (sweet cherry)
Class
Metabolism; Metabolism of other amino acids
Pathway map
pavi00480  Glutathione metabolism
pavi00480

Module
pavi_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:pavi00480]
Other DBs
GO: 0006749
Organism
Prunus avium (sweet cherry) [GN:pavi]
Gene
110747899  gamma-glutamyltranspeptidase 1-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110751084  gamma-glutamyltranspeptidase 3-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110774412  gamma-glutamyltranspeptidase 2-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
110761222  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
110750525  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
110759826  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
110760917  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
110760923  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
110759684  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
110756922  leucine aminopeptidase 1-like [KO:K01255] [EC:3.4.11.1]
110762452  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
110770534  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110762273  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
110762274  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
110771024  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
110771832  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750791  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
110772738  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110760473  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
110761756  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
110761758  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110746866  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110758021  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
110772541  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769812  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769813  glutathione S-transferase U8-like [KO:K00799] [EC:2.5.1.18]
110745233  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110747533  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110747534  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110748995  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110772745  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110772764  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110772774  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110772784  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
110750866  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110750867  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110751939  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110770809  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
110765075  glutathione S-transferase U19-like [KO:K00799] [EC:2.5.1.18]
110762367  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
110762378  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
110762389  glutathione S-transferase U9-like [KO:K00799] [EC:2.5.1.18]
110761069  protein IN2-1 homolog B-like [KO:K00799] [EC:2.5.1.18]
110772807  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
110772813  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
110772847  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110772857  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750902  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750903  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750904  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110750923  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110746659  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
110750084  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110765923  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
110765924  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
110765940  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
110750085  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750086  glutathione transferase GST 23-like [KO:K00799] [EC:2.5.1.18]
110750087  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750088  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110750097  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
110765104  glutathione S-transferase F11-like [KO:K00799] [EC:2.5.1.18]
110767241  glutathione S-transferase L3-like [KO:K00799] [EC:2.5.1.18]
110751417  glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
110772879  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
110772890  glutathione S-transferase U17-like [KO:K00799] [EC:2.5.1.18]
110755366  glutathione S-transferase F13-like [KO:K00799] [EC:2.5.1.18]
110747030  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110765155  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769424  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769425  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769426  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110769427  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110770522  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
110755157  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110756668  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
110763442  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
110758941  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
110762040  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110765103  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
110746469  isocitrate dehydrogenase [NADP]-like isoform X1 [KO:K00031] [EC:1.1.1.42]
110762205  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110759612  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
110749983  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110756779  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110745274  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110766086  glucose-6-phosphate 1-dehydrogenase, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110758018  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
110758024  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110758032  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110745560  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110762682  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
110758026  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
110751599  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
110761545  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
110761550  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
110767151  spermine synthase [KO:K00797] [EC:2.5.1.16]
110753233  spermidine synthase [KO:K00797] [EC:2.5.1.16]
110766942  spermidine synthase 1-like [KO:K00797] [EC:2.5.1.16]
110758673  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
110750580  probable L-ascorbate peroxidase 6, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
110763755  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
110758720  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
110752748  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
110753793  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
110744516  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
110750688  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
110747817  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
110764370  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
110750467  ribonucleoside-diphosphate reductase small chain A isoform X1 [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
pavi00220  Arginine biosynthesis
pavi00250  Alanine, aspartate and glutamate metabolism
pavi00270  Cysteine and methionine metabolism
pavi00430  Taurine and hypotaurine metabolism
pavi00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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