KEGG   PATHWAY: pdul00999
Entry
pdul00999                   Pathway                                
Name
Biosynthesis of various plant secondary metabolites - Prunus dulcis (almond)
  Including
Crocin biosynthesis, Ginsenoside biosynthesis, Saponin adjuvant biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
pdul00999  Biosynthesis of various plant secondary metabolites
pdul00999

Organism
Prunus dulcis (almond) [GN:pdul]
Gene
117620929  beta-amyrin synthase-like isoform X1 [KO:K15813] [EC:5.4.99.39]
117621182  beta-amyrin synthase-like [KO:K15813] [EC:5.4.99.39]
117624085  beta-amyrin synthase-like [KO:K15813] [EC:5.4.99.39]
117622046  beta-amyrin synthase isoform X1 [KO:K15813] [EC:5.4.99.39]
117622047  beta-amyrin synthase-like isoform X1 [KO:K15813] [EC:5.4.99.39]
117622048  beta-amyrin synthase-like isoform X1 [KO:K15813] [EC:5.4.99.39]
117630226  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117630227  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117630228  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117620802  beta-amyrin 28-monooxygenase [KO:K20667] [EC:1.14.14.126]
117624361  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117624362  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117624363  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117624364  beta-amyrin 28-monooxygenase-like [KO:K20667] [EC:1.14.14.126]
117631500  S-adenosylmethionine synthase 2-like [KO:K00789] [EC:2.5.1.6]
117620911  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
117622590  S-adenosylmethionine synthase 5 [KO:K00789] [EC:2.5.1.6]
117633942  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
117631595  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
117622689  nicotianamine synthase-like [KO:K05953] [EC:2.5.1.43]
117631401  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
117632077  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like [KO:K13832] [EC:4.2.1.10 1.1.1.25]
117632842  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
117633161  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like isoform X1 [KO:K13832] [EC:4.2.1.10 1.1.1.25]
117633163  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic-like [KO:K13832] [EC:4.2.1.10 1.1.1.25]
117612243  putative UDP-glucose glucosyltransferase [KO:K23279] [EC:2.4.1.136]
117637063  putative UDP-glucose glucosyltransferase [KO:K23279] [EC:2.4.1.136]
117630028  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
117630080  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
117617364  beta-glucosidase 12-like [KO:K01188] [EC:3.2.1.21]
117630138  LOW QUALITY PROTEIN: beta-glucosidase 24-like [KO:K01188] [EC:3.2.1.21]
117630054  beta-glucosidase 13-like [KO:K01188] [EC:3.2.1.21]
117630785  beta-glucosidase 11-like isoform X1 [KO:K01188] [EC:3.2.1.21]
117631057  beta-glucosidase 42 [KO:K01188] [EC:3.2.1.21]
117631085  beta-glucosidase 11-like [KO:K01188] [EC:3.2.1.21]
117624535  putative beta-glucosidase 41 isoform X1 [KO:K01188] [EC:3.2.1.21]
117636642  cyanogenic beta-glucosidase-like [KO:K01188] [EC:3.2.1.21]
117636891  beta-glucosidase 40-like [KO:K01188] [EC:3.2.1.21]
117615897  beta-glucosidase 24-like [KO:K01188] [EC:3.2.1.21]
117618618  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117618674  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117630301  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
117630864  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
117619788  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
117631141  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
117631167  lysosomal beta glucosidase-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117631323  lysosomal beta glucosidase-like [KO:K05349] [EC:3.2.1.21]
117631361  beta-glucosidase BoGH3B-like [KO:K05349] [EC:3.2.1.21]
117632218  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117633969  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117634249  beta-glucosidase BoGH3B-like isoform X1 [KO:K05349] [EC:3.2.1.21]
117624675  LOW QUALITY PROTEIN: beta-glucosidase 47-like [KO:K05350] [EC:3.2.1.21]
117626270  beta-glucosidase 45-like isoform X1 [KO:K05350] [EC:3.2.1.21]
117627723  beta-glucosidase 44 [KO:K05350] [EC:3.2.1.21]
117633030  feruloyl CoA ortho-hydroxylase F6H1-3-like [KO:K06892] [EC:1.14.11.61]
117626205  scopoletin 8-hydroxylase [KO:K23145] [EC:1.14.11.60]
117615155  xanthotoxin 5-hydroxylase CYP82C4-like [KO:K23136] [EC:1.14.14.164]
117612253  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
117636488  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
117636489  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
117637346  scopoletin glucosyltransferase-like [KO:K23260] [EC:2.4.1.128]
117638085  UDP-glucose flavonoid 3-O-glucosyltransferase 7-like [KO:K23260] [EC:2.4.1.128]
117638510  UDP-glucose flavonoid 3-O-glucosyltransferase 7-like [KO:K23260] [EC:2.4.1.128]
117638512  UDP-glucose flavonoid 3-O-glucosyltransferase 7-like [KO:K23260] [EC:2.4.1.128]
117628069  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117628098  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117628169  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117628285  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117613517  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117627184  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117627185  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
117627188  isoflavone reductase homolog [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
Compound
C00019  S-Adenosyl-L-methionine
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00049  L-Aspartate
C00073  L-Methionine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00108  Anthranilate
C00179  Agmatine
C00223  p-Coumaroyl-CoA
C00251  Chorismate
C00254  Prephenate
C00323  Caffeoyl-CoA
C00353  Geranylgeranyl diphosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00448  trans,trans-Farnesyl diphosphate
C00463  Indole
C00493  Shikimate
C00590  Coniferyl alcohol
C00751  Squalene
C00758  Bergaptol
C00841  Xanthotoxol
C01054  (S)-2,3-Epoxysqualene
C01158  1-O-Galloyl-beta-D-glucose
C01198  3-(2-Hydroxyphenyl)propanoate
C01424  Gallate
C01527  Scopolin
C01557  Bergapten
C01752  Scopoletin
C01772  trans-2-Hydroxycinnamate
C01864  Xanthotoxin
C02162  Isopimpinellin
C02274  Dihydrocoumarin
C02637  3-Dehydroshikimate
C02951  5-Hydroxyxanthotoxin
C03506  Indoleglycerol phosphate
C04498  p-Coumaroylagmatine
C04576  Pentagalloylglucose
C04831  DIMBOA-glucoside
C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
C05324  Nicotianamine
C05366  (+)-Pinoresinol
C05838  cis-2-Hydroxycinnamate
C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
C05851  Coumarin
C06098  Zeaxanthin
C06972  Dronabinol
C07578  Cannabidiol
C08304  Gramine
C08307  Hordatine A
C08308  Hordatine B
C08588  Crocetin
C08589  Crocin
C08616  beta-Amyrin
C08942  Echinocystic acid
C08946  Ginsenoside Rg1
C08972  Quillaic acid
C09060  Angelicin
C09263  Esculetin
C09265  Fraxetin
C09276  Marmesin
C09305  Psoralen
C09311  Scoparone
C09315  Umbelliferone
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10646  Lariciresinol
C10682  Matairesinol
C10784  Cannabidiolic acid
C10874  Podophyllotoxin
C11130  3-Hydroxyindolin-2-one
C12312  Indolin-2-one
C15485  2'-Deoxymugineic acid
C15486  3''-Deamino-3''-oxonicotianamine
C15500  Mugineic acid
C15501  3-Epihydroxymugineic acid
C15502  3-Epihydroxy-2'-deoxymugineic acid
C15769  HBOA
C15770  DIBOA
C15772  DIBOA-glucoside
C17055  Picrocrocin
C17062  Safranal
C17148  Oleanolic acid
C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
C18062  TRIBOA-glucoside
C18079  Isoscopoletin
C18080  Osthenol
C18083  Demethylsuberosin
C18167  Secoisolariciresinol
C18325  Feruloylagmatine
C19707  (+)-Columbianetin
C19730  Crocetin dialdehyde
C19731  (3S)-3-Hydroxycyclocitral
C19829  Dammarenediol-II
C19867  beta-D-Glucosyl crocetin
C19868  Bis(beta-D-glucosyl) crocetin
C19869  beta-D-Gentiobiosyl crocetin
C20406  Cannabigerolate
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20713  Ginsenoside Rb1
C20715  Protopanaxadiol
C20716  Protopanaxatriol
C20725  Ginsenoside Rd
C20778  Ginsenoside Rg3
C20779  Ginsenoside F2
C20780  Ginsenoside F1
C20894  beta-Citraurin
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21459  6-Hydroxyferuloyl-CoA
C21601  3-(Aminomethyl)indole
C21602  (1H-Indol-3-yl)-N-methylmethanamine
C21903  Delta9-Tetrahydrocannabinolate
C22007  Sideretin
C22070  2,4-Dihydroxycinnamoyl-CoA
C22127  Ginsenoside C-K
C22128  (20S)-Ginsenoside Rh2
C22129  Ginsenoside Rh1
C22152  Bergamottin
C22153  Epoxybergamottin
C22156  6',7'-Dihydroxybergamottin
C22438  3,5-Dehydroshikimate
C22444  5,8-Dihydroxypsoralen
C22445  8-Hydroxybergapten
C22452  6,7,8-Trihydroxycoumarin
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22655  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22657  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22659  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22661  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22662  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22663  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22665  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
PMID:22569263
  Authors
Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  Title
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  Journal
FEBS Lett 586:1055-61 (2012)
DOI:10.1016/j.febslet.2012.03.003
Reference
PMID:17544411
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
Reference
PMID:9952442
  Authors
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  Title
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  Journal
Plant Physiol 119:471-80 (1999)
DOI:10.1104/pp.119.2.471
Reference
PMID:7622460
  Authors
Ma JF, Shinada T, Matsuda C, Nomoto K
  Title
Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  Journal
J Biol Chem 270:16549-54 (1995)
DOI:10.1074/jbc.270.28.16549
Reference
PMID:33346890
  Authors
Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  Title
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  Journal
Planta 253:3 (2020)
DOI:10.1007/s00425-020-03516-w
Reference
PMID:26558757
  Authors
Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  Title
The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  Journal
PLoS One 10:e0142757 (2015)
DOI:10.1371/journal.pone.0142757
Reference
PMID:15009205
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur J Biochem 271:932-40 (2004)
DOI:10.1111/j.1432-1033.2004.03995.x
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
PMID:36952412
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
Related
pathway
pdul00010  Glycolysis / Gluconeogenesis
pdul00020  Citrate cycle (TCA cycle)
pdul00270  Cysteine and methionine metabolism
pdul00400  Phenylalanine, tyrosine and tryptophan biosynthesis
pdul00900  Terpenoid backbone biosynthesis
pdul00940  Phenylpropanoid biosynthesis
KO pathway
ko00999   
LinkDB

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