KEGG   PATHWAY: phas04740
Entry
phas04740                   Pathway                                
Name
Olfactory transduction - Phyllostomus hastatus (greater spear-nosed bat)
Description
Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.
Class
Organismal Systems; Sensory system
Pathway map
phas04740  Olfactory transduction
phas04740

Other DBs
GO: 0007608
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123811306  olfactory receptor 56-like [KO:K04257]
123811357  LOW QUALITY PROTEIN: olfactory receptor 1A1-like [KO:K04257]
123811358  olfactory receptor 1G1-like [KO:K04257]
123825929  olfactory receptor 10A7-like [KO:K04257]
123825938  LOW QUALITY PROTEIN: putative gustatory receptor clone PTE01 [KO:K04257]
123825939  olfactory receptor 18-like [KO:K04257]
123825941  olfactory receptor 7C1-like [KO:K04257]
123825942  putative olfactory receptor 7A2 [KO:K04257]
123825940  LOW QUALITY PROTEIN: olfactory receptor 5-like [KO:K04257]
123825953  olfactory receptor 5A2-like [KO:K04257]
123819015  olfactory receptor 4D1-like [KO:K04257]
123819016  olfactory receptor 4D2 [KO:K04257]
123819182  olfactory receptor 51V1 [KO:K04257]
123819188  olfactory receptor 51G2-like [KO:K04257]
123819189  olfactory receptor 52W1 [KO:K04257]
123819190  olfactory receptor 52K1-like [KO:K04257]
123819194  olfactory receptor 52N4-like [KO:K04257]
123819205  olfactory receptor 52B6 [KO:K04257]
123819207  olfactory receptor 52H1-like [KO:K04257]
123819209  putative olfactory receptor 52P1 [KO:K04257]
123819217  olfactory receptor 52E4-like [KO:K04257]
123819218  olfactory receptor 52K2-like [KO:K04257]
123819219  olfactory receptor 52D1-like [KO:K04257]
123819220  olfactory receptor 52A1-like [KO:K04257]
123819221  LOW QUALITY PROTEIN: putative olfactory receptor 52P1 [KO:K04257]
123819222  olfactory receptor 52Z1-like [KO:K04257]
123819223  olfactory receptor 51V1-like [KO:K04257]
123819225  olfactory receptor 51G2-like [KO:K04257]
123819226  olfactory receptor 51G2-like [KO:K04257]
123819227  olfactory receptor 51A4-like [KO:K04257]
123819229  olfactory receptor 51V1-like [KO:K04257]
123819230  olfactory receptor 51V1-like [KO:K04257]
123819231  olfactory receptor 51V1-like [KO:K04257]
123819233  olfactory receptor 52A5 [KO:K04257]
123819234  olfactory receptor 51G2-like [KO:K04257]
123819235  olfactory receptor 51B2-like [KO:K04257]
123819236  LOW QUALITY PROTEIN: olfactory receptor 51L1-like [KO:K04257]
123819237  olfactory receptor 51Q1 [KO:K04257]
123819238  olfactory receptor 51I2-like [KO:K04257]
123819240  olfactory receptor 52D1 [KO:K04257]
123819251  putative olfactory receptor 52P1 [KO:K04257]
123819252  putative olfactory receptor 52P1 [KO:K04257]
123819255  olfactory receptor 52N5-like [KO:K04257]
123819258  LOW QUALITY PROTEIN: putative olfactory receptor 56B2 [KO:K04257]
123819259  LOW QUALITY PROTEIN: olfactory receptor 52E4-like [KO:K04257]
123819260  olfactory receptor 56A3-like [KO:K04257]
123819262  olfactory receptor 56A1-like [KO:K04257]
123819263  olfactory receptor 52L1-like [KO:K04257]
123819264  olfactory receptor 56B4-like [KO:K04257]
123819265  LOW QUALITY PROTEIN: olfactory receptor 688-like [KO:K04257]
123819266  olfactory receptor 52B2-like [KO:K04257]
123819267  olfactory receptor 52B2 [KO:K04257]
123819274  olfactory receptor 52E2-like [KO:K04257]
123819275  olfactory receptor 52E2-like [KO:K04257]
123819278  LOW QUALITY PROTEIN: olfactory receptor 52E8-like [KO:K04257]
123819280  olfactory receptor 52E8 [KO:K04257]
123819281  olfactory receptor 52H1 [KO:K04257]
123819282  olfactory receptor 52E4 [KO:K04257]
123819283  olfactory receptor 52J3 [KO:K04257]
123819284  olfactory receptor 52E8-like [KO:K04257]
123819285  olfactory receptor 51B5 isoform X1 [KO:K04257]
123819286  LOW QUALITY PROTEIN: olfactory receptor 52E5-like [KO:K04257]
123819288  olfactory receptor 51B6 [KO:K04257]
123819289  olfactory receptor 52Z1-like [KO:K04257]
123819291  olfactory receptor 51B2-like [KO:K04257]
123819292  olfactory receptor 52N4 [KO:K04257]
123819293  olfactory receptor 51B6-like [KO:K04257]
123819294  olfactory receptor 51I2-like [KO:K04257]
123819295  olfactory receptor 56A1-like [KO:K04257]
123819297  olfactory receptor 51I2-like [KO:K04257]
123819299  olfactory receptor 56A1 [KO:K04257]
123819301  olfactory receptor 56A4-like [KO:K04257]
123819302  olfactory receptor 51I1 [KO:K04257]
123819303  LOW QUALITY PROTEIN: olfactory receptor 56A4-like [KO:K04257]
123819304  olfactory receptor 51I2 [KO:K04257]
123819305  olfactory receptor 56A4-like [KO:K04257]
123819308  LOW QUALITY PROTEIN: olfactory receptor 52N2-like [KO:K04257]
123819309  LOW QUALITY PROTEIN: olfactory receptor 51A4-like [KO:K04257]
123819311  olfactory receptor 52N2 [KO:K04257]
123819313  olfactory receptor 51A4-like [KO:K04257]
123819314  olfactory receptor 51A4-like [KO:K04257]
123819316  olfactory receptor 51A4-like [KO:K04257]
123819318  olfactory receptor 52D1-like [KO:K04257]
123819319  olfactory receptor 52K1-like [KO:K04257]
123826550  olfactory receptor 2M2-like [KO:K04257]
123826553  LOW QUALITY PROTEIN: olfactory receptor 2M4-like [KO:K04257]
123826592  olfactory receptor 2B11 [KO:K04257]
123826596  olfactory receptor 2W3 [KO:K04257]
123826659  putative olfactory receptor 2W6 [KO:K04257]
123826706  olfactory receptor 51A4-like [KO:K04257]
123826708  olfactory receptor 51L1-like [KO:K04257]
123826753  LOW QUALITY PROTEIN: olfactory receptor 5-like [KO:K04257]
123833490  olfactory receptor 11A1-like [KO:K04257]
123804937  LOW QUALITY PROTEIN: olfactory receptor 10V1-like [KO:K04257]
123804938  olfactory receptor 3A1-like [KO:K04257]
123804940  olfactory receptor 3A1-like [KO:K04257]
123812001  olfactory receptor 3A1-like [KO:K04257]
123812347  LOW QUALITY PROTEIN: olfactory receptor 10A7 [KO:K04257]
123812365  olfactory receptor 12-like [KO:K04257]
123819320  LOW QUALITY PROTEIN: olfactory receptor 688-like [KO:K04257]
123819321  LOW QUALITY PROTEIN: olfactory receptor 56B4-like [KO:K04257]
123819326  olfactory receptor 51J1 [KO:K04257]
123819327  olfactory receptor 52D1-like [KO:K04257]
123819328  olfactory receptor 51I2-like [KO:K04257]
123819594  olfactory receptor 13C7-like [KO:K04257]
123819607  LOW QUALITY PROTEIN: olfactory receptor 13C4-like [KO:K04257]
123819610  olfactory receptor 13C7-like [KO:K04257]
123819611  LOW QUALITY PROTEIN: olfactory receptor 13C8-like [KO:K04257]
123819613  olfactory receptor 13F1-like [KO:K04257]
123819636  olfactory receptor 1J4-like [KO:K04257]
123819637  LOW QUALITY PROTEIN: olfactory receptor 1J4-like [KO:K04257]
123827296  olfactory receptor 5AC1-like [KO:K04257]
123827298  olfactory receptor 5AC2 [KO:K04257]
123827300  olfactory receptor 5H2 [KO:K04257]
123805278  olfactory receptor 52K1-like [KO:K04257]
123805313  olfactory receptor 51A4-like [KO:K04257]
123805314  olfactory receptor 51H1-like [KO:K04257]
123805315  olfactory receptor 51H1-like [KO:K04257]
123805316  LOW QUALITY PROTEIN: olfactory receptor 51F1 [KO:K04257]
123805318  olfactory receptor 51F1-like [KO:K04257]
123805319  olfactory receptor 51I2-like [KO:K04257]
123805320  olfactory receptor 51I2-like [KO:K04257]
123805321  olfactory receptor 51E1 [KO:K04257]
123805322  olfactory receptor 52I2-like [KO:K04257]
123805323  olfactory receptor 52M1 [KO:K04257]
123805324  olfactory receptor 52K1-like [KO:K04257]
123805325  olfactory receptor 51G2-like [KO:K04257]
123805326  olfactory receptor 52B4-like [KO:K04257]
123805327  olfactory receptor 52B4-like [KO:K04257]
123805334  olfactory receptor 2AT4-like [KO:K04257]
123805336  olfactory receptor 2AT4-like [KO:K04257]
123805469  olfactory receptor 51E2 [KO:K04257]
123805471  olfactory receptor 51F2-like [KO:K04257]
123805515  olfactory receptor 51F1-like [KO:K04257]
123812580  olfactory receptor 9 [KO:K04257]
123812582  LOW QUALITY PROTEIN: olfactory receptor 6C2-like [KO:K04257]
123812584  olfactory receptor 6C2-like [KO:K04257]
123812585  LOW QUALITY PROTEIN: olfactory receptor 6C4-like [KO:K04257]
123812588  LOW QUALITY PROTEIN: olfactory receptor 6C2-like [KO:K04257]
123812589  olfactory receptor 6C75-like [KO:K04257]
123812590  olfactory receptor 6C6-like [KO:K04257]
123812592  LOW QUALITY PROTEIN: olfactory receptor 6C6-like [KO:K04257]
123812594  olfactory receptor 6C76 [KO:K04257]
123812598  LOW QUALITY PROTEIN: olfactory receptor 6C65-like [KO:K04257]
123812600  olfactory receptor 6C6 [KO:K04257]
123812601  olfactory receptor 10C1-like [KO:K04257]
123812619  olfactory receptor 8S1-like [KO:K04257]
123812620  olfactory receptor 8S1-like [KO:K04257]
123812623  olfactory receptor 8S1-like [KO:K04257]
123812625  LOW QUALITY PROTEIN: olfactory receptor 8S1-like [KO:K04257]
123812626  olfactory receptor 8S1-like [KO:K04257]
123812628  LOW QUALITY PROTEIN: olfactory receptor 10AD1 [KO:K04257]
123812672  olfactory receptor 2G3-like [KO:K04257]
123812679  olfactory receptor 6C2-like [KO:K04257]
123812685  olfactory receptor 6C2-like [KO:K04257]
123812686  olfactory receptor 6C2-like [KO:K04257]
123812695  olfactory receptor 6C2-like [KO:K04257]
123812696  LOW QUALITY PROTEIN: olfactory receptor 6C2-like [KO:K04257]
123812705  LOW QUALITY PROTEIN: olfactory receptor 6C2-like [KO:K04257]
123812714  olfactory receptor 6C2 [KO:K04257]
123812726  olfactory receptor 6C2-like [KO:K04257]
123812730  olfactory receptor 6C70-like [KO:K04257]
123812741  olfactory receptor 6C2-like [KO:K04257]
123812746  olfactory receptor 6C2-like [KO:K04257]
123812749  olfactory receptor 6C2-like [KO:K04257]
123812760  olfactory receptor 6C6-like [KO:K04257]
123819991  olfactory receptor 13C7-like [KO:K04257]
123819995  olfactory receptor 13C7-like [KO:K04257]
123819999  olfactory receptor 13C7-like [KO:K04257]
123820000  olfactory receptor 13C7 [KO:K04257]
123820021  olfactory receptor 13C3 [KO:K04257]
123820034  olfactory receptor 13C9 [KO:K04257]
123820035  olfactory receptor 13C7-like [KO:K04257]
123820075  olfactory receptor 13F1-like [KO:K04257]
123820086  olfactory receptor 2S2 [KO:K04257]
123820103  olfactory receptor 13D1 [KO:K04257]
123820153  olfactory receptor 2K2 [KO:K04257]
123820219  olfactory receptor 1L8-like [KO:K04257]
123820234  olfactory receptor 13J1-like [KO:K04257]
123827511  olfactory receptor 5K4 [KO:K04257]
123827705  olfactory receptor 5AS1-like [KO:K04257]
123827708  olfactory receptor 5AS1-like [KO:K04257]
123827709  olfactory receptor 1052-like [KO:K04257]
123827710  olfactory receptor 5AS1-like [KO:K04257]
123827712  olfactory receptor 1052-like [KO:K04257]
123805516  olfactory receptor 51F2-like [KO:K04257]
123805521  olfactory receptor 51F2-like [KO:K04257]
123805522  olfactory receptor 52E2 [KO:K04257]
123805523  olfactory receptor 51F2-like [KO:K04257]
123805525  olfactory receptor 51G2 [KO:K04257]
123805527  olfactory receptor 51F2-like [KO:K04257]
123805538  LOW QUALITY PROTEIN: olfactory receptor 51I2-like [KO:K04257]
123805539  olfactory receptor 51F2 [KO:K04257]
123805540  olfactory receptor 51A4-like [KO:K04257]
123805546  olfactory receptor 51G1 [KO:K04257]
123805559  olfactory receptor 51A4-like [KO:K04257]
123805562  olfactory receptor 51A7-like [KO:K04257]
123805565  olfactory receptor 51H1-like [KO:K04257]
123805576  olfactory receptor 52R1 [KO:K04257]
123805590  olfactory receptor 51D1 [KO:K04257]
123805592  olfactory receptor 52K1 [KO:K04257]
123805597  olfactory receptor 52B4-like [KO:K04257]
123805605  olfactory receptor 2AT4 [KO:K04257]
123805608  olfactory receptor 52M1-like [KO:K04257]
123805614  olfactory receptor 52B4-like [KO:K04257]
123805634  olfactory receptor 51G2-like [KO:K04257]
123805636  putative olfactory receptor 52P1 [KO:K04257]
123805637  olfactory receptor 51T1 [KO:K04257]
123805645  olfactory receptor 51S1 [KO:K04257]
123812777  olfactory receptor 6C3 [KO:K04257]
123812780  olfactory receptor 6C68-like [KO:K04257]
123812781  olfactory receptor 6C6-like [KO:K04257]
123812784  olfactory receptor 6C2-like [KO:K04257]
123812786  olfactory receptor 6C75-like [KO:K04257]
123812792  olfactory receptor 6C1 isoform X1 [KO:K04257]
123812805  LOW QUALITY PROTEIN: olfactory receptor 6C4-like [KO:K04257]
123812813  olfactory receptor 6C74-like [KO:K04257]
123812836  olfactory receptor 6C2-like [KO:K04257]
123812843  olfactory receptor 2AP1 isoform X1 [KO:K04257]
123812990  LOW QUALITY PROTEIN: olfactory receptor 56-like [KO:K04257]
123812996  olfactory receptor 2V2-like [KO:K04257]
123813006  olfactory receptor 56-like [KO:K04257]
123813014  olfactory receptor 15-like [KO:K04257]
123813050  olfactory receptor 9K2 [KO:K04257]
123813054  olfactory receptor 1361-like [KO:K04257]
123813063  olfactory receptor 14K1-like [KO:K04257]
123813076  olfactory receptor 1044-like [KO:K04257]
123820412  LOW QUALITY PROTEIN: olfactory receptor 6J1 [KO:K04257]
123820413  olfactory receptor 49-like [KO:K04257]
123820575  olfactory receptor 10J1-like [KO:K04257]
123828284  olfactory receptor 7A17-like [KO:K04257]
123828285  olfactory receptor 7A17-like [KO:K04257]
123828287  LOW QUALITY PROTEIN: olfactory receptor 7C1-like [KO:K04257]
123828307  olfactory receptor 7A10-like [KO:K04257]
123828370  LOW QUALITY PROTEIN: olfactory receptor 7A17-like [KO:K04257]
123828375  olfactory receptor 7A17-like [KO:K04257]
123821255  olfactory receptor 10A4-like [KO:K04257]
123821264  olfactory receptor 491-like [KO:K04257]
123821265  olfactory receptor 491-like [KO:K04257]
123821266  olfactory receptor 502 [KO:K04257]
123821268  LOW QUALITY PROTEIN: olfactory receptor 2D3 [KO:K04257]
123821269  LOW QUALITY PROTEIN: olfactory receptor 2D3-like [KO:K04257]
123821270  LOW QUALITY PROTEIN: olfactory receptor 2D3-like [KO:K04257]
123821271  olfactory receptor 2D2 [KO:K04257]
123821272  olfactory receptor 2D2-like [KO:K04257]
123821273  olfactory receptor 481-like [KO:K04257]
123828418  olfactory receptor 7D4-like [KO:K04257]
123828447  olfactory receptor 10H1 [KO:K04257]
123828469  olfactory receptor 10H2-like [KO:K04257]
123828486  olfactory receptor 18-like [KO:K04257]
123828520  olfactory receptor 7E24-like [KO:K04257]
123828521  putative gustatory receptor clone PTE01 [KO:K04257]
123828538  olfactory receptor 2Z1-like [KO:K04257]
123828539  putative olfactory receptor 7A2 [KO:K04257]
123828549  olfactory receptor 7A17-like [KO:K04257]
123828550  olfactory receptor 7D4-like [KO:K04257]
123828551  olfactory receptor 7A17-like [KO:K04257]
123828553  olfactory receptor 7A10-like [KO:K04257]
123828554  olfactory receptor 7A10-like [KO:K04257]
123828555  olfactory receptor 7A10-like [KO:K04257]
123828557  olfactory receptor 7D4-like [KO:K04257]
123828558  olfactory receptor 7A17-like [KO:K04257]
123828559  olfactory receptor 7A10-like [KO:K04257]
123828560  olfactory receptor 7D4-like [KO:K04257]
123828561  olfactory receptor 7A10-like [KO:K04257]
123828562  olfactory receptor 7A10-like [KO:K04257]
123828567  LOW QUALITY PROTEIN: olfactory receptor 1I1 [KO:K04257]
123828568  olfactory receptor 10T2-like [KO:K04257]
123828574  olfactory receptor 2Z1-like [KO:K04257]
123806582  olfactory receptor 145-like [KO:K04257]
123806629  olfactory receptor 8B4-like [KO:K04257]
123813872  olfactory receptor 18-like [KO:K04257]
123813888  olfactory receptor 7A17-like [KO:K04257]
123813889  olfactory receptor 7C1-like [KO:K04257]
123813890  olfactory receptor 7A17-like [KO:K04257]
123813892  olfactory receptor 7D4-like [KO:K04257]
123813894  olfactory receptor 7D4-like [KO:K04257]
123813896  olfactory receptor 7E24-like [KO:K04257]
123813954  olfactory receptor 7D2-like isoform X1 [KO:K04257]
123814018  olfactory receptor 7G3-like [KO:K04257]
123814064  olfactory receptor 18-like [KO:K04257]
123814066  LOW QUALITY PROTEIN: olfactory receptor 18-like [KO:K04257]
123814067  olfactory receptor 18-like [KO:K04257]
123814109  olfactory receptor 24 [KO:K04257]
123807258  LOW QUALITY PROTEIN: olfactory receptor 1F1 [KO:K04257]
123814138  LOW QUALITY PROTEIN: olfactory receptor 18-like [KO:K04257]
123814637  olfactory receptor 5F1-like [KO:K04257]
123829258  olfactory receptor 4D11-like [KO:K04257]
123829260  olfactory receptor 5A1 [KO:K04257]
123829261  olfactory receptor 5A1-like [KO:K04257]
123829266  olfactory receptor 5B3-like [KO:K04257]
123829419  olfactory receptor 4D11 [KO:K04257]
123829504  olfactory receptor 4D6 [KO:K04257]
123829505  olfactory receptor 4D6-like [KO:K04257]
123829525  olfactory receptor 1444 [KO:K04257]
123829528  olfactory receptor 5B12 [KO:K04257]
123829550  olfactory receptor 1440-like [KO:K04257]
123829551  olfactory receptor 5A2-like [KO:K04257]
123807864  olfactory receptor 4S2-like [KO:K04257]
123807867  olfactory receptor 10AC1-like [KO:K04257]
123815495  olfactory receptor 1044-like [KO:K04257]
123823076  olfactory receptor 10G2-like [KO:K04257]
123823089  olfactory receptor 3A1-like [KO:K04257]
123830188  LOW QUALITY PROTEIN: olfactory receptor 1A1-like [KO:K04257]
123830194  LOW QUALITY PROTEIN: olfactory receptor 1P1-like [KO:K04257]
123808429  LOW QUALITY PROTEIN: olfactory receptor 11G2-like [KO:K04257]
123808434  olfactory receptor 11H12-like [KO:K04257]
123808436  olfactory receptor 11G2-like [KO:K04257]
123808437  olfactory receptor 4Q3 [KO:K04257]
123808440  olfactory receptor 4M1 [KO:K04257]
123808444  olfactory receptor 4N2-like [KO:K04257]
123808446  olfactory receptor 4K2 [KO:K04257]
123808448  olfactory receptor 4K1 [KO:K04257]
123808450  olfactory receptor 4N5 [KO:K04257]
123808472  olfactory receptor 4F15-like [KO:K04257]
123808503  LOW QUALITY PROTEIN: olfactory receptor 4E1 [KO:K04257]
123808504  olfactory receptor 1509 [KO:K04257]
123808552  olfactory receptor 4F15-like [KO:K04257]
123808559  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123823295  LOW QUALITY PROTEIN: olfactory receptor 1Q1-like [KO:K04257]
123823305  olfactory receptor 1361-like [KO:K04257]
123823306  putative olfactory receptor 3A4 [KO:K04257]
123823307  olfactory receptor 1J4-like [KO:K04257]
123823308  olfactory receptor 1J4-like [KO:K04257]
123823309  LOW QUALITY PROTEIN: olfactory receptor 1J4-like [KO:K04257]
123823311  LOW QUALITY PROTEIN: olfactory receptor 1J4-like [KO:K04257]
123823312  LOW QUALITY PROTEIN: olfactory receptor 50-like [KO:K04257]
123823313  LOW QUALITY PROTEIN: olfactory receptor 1J4-like [KO:K04257]
123823314  olfactory receptor 1N2 [KO:K04257]
123823315  olfactory receptor 1G1-like [KO:K04257]
123823404  LOW QUALITY PROTEIN: olfactory receptor 1J1-like [KO:K04257]
123823434  olfactory receptor 1N1 [KO:K04257]
123808576  olfactory receptor 11G2 [KO:K04257]
123808578  olfactory receptor 11G2-like [KO:K04257]
123808584  LOW QUALITY PROTEIN: olfactory receptor 11H4-like [KO:K04257]
123808587  olfactory receptor 11H7-like [KO:K04257]
123808593  olfactory receptor 11H7 [KO:K04257]
123808605  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808612  olfactory receptor 4F15 [KO:K04257]
123808623  olfactory receptor 11H6-like [KO:K04257]
123808658  olfactory receptor 4F6-like [KO:K04257]
123808659  olfactory receptor 4L1-like [KO:K04257]
123808669  olfactory receptor 1361-like [KO:K04257]
123808672  olfactory receptor 10G2 [KO:K04257]
123808689  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808690  olfactory receptor 4F6-like [KO:K04257]
123808692  olfactory receptor 4F3/4F16/4F29 [KO:K04257]
123808695  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808699  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808706  olfactory receptor 4N2-like [KO:K04257]
123808710  olfactory receptor 4K2-like [KO:K04257]
123808711  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808719  olfactory receptor 4F3/4F16/4F29-like [KO:K04257]
123808738  olfactory receptor 10G3 [KO:K04257]
123808761  olfactory receptor 10G2 [KO:K04257]
123808818  LOW QUALITY PROTEIN: olfactory receptor 4E1-like [KO:K04257]
123808921  olfactory receptor 5AU1 [KO:K04257]
123808973  olfactory receptor 6S1 [KO:K04257]
123816362  olfactory receptor 5B3-like [KO:K04257]
123823497  olfactory receptor 1J4-like [KO:K04257]
123823530  olfactory receptor 1361-like [KO:K04257]
123823552  olfactory receptor 1L4 [KO:K04257]
123823571  olfactory receptor 1L3-like [KO:K04257]
123823609  olfactory receptor 5C1 [KO:K04257]
123823841  olfactory receptor 4A5-like [KO:K04257]
123830942  olfactory receptor 6V1 [KO:K04257]
123830944  olfactory receptor 2A2-like [KO:K04257]
123830947  olfactory receptor 10AC1-like [KO:K04257]
123830948  olfactory receptor 10AC1-like [KO:K04257]
123830949  olfactory receptor-like protein OLF3 [KO:K04257]
123830950  olfactory receptor 6B1 [KO:K04257]
123830951  LOW QUALITY PROTEIN: olfactory receptor 2A12-like [KO:K04257]
123830952  olfactory receptor 13-like [KO:K04257]
123830954  olfactory receptor 2A12-like [KO:K04257]
123830958  olfactory receptor 2A2-like [KO:K04257]
123830959  olfactory receptor 13-like [KO:K04257]
123830960  olfactory receptor 2A2-like [KO:K04257]
123830968  olfactory receptor 2A25-like [KO:K04257]
123830971  olfactory receptor 9A4 [KO:K04257]
123830973  olfactory receptor 13-like [KO:K04257]
123830974  olfactory receptor 2A14-like [KO:K04257]
123830975  olfactory receptor 13-like [KO:K04257]
123830976  olfactory receptor 2A2-like [KO:K04257]
123830977  olfactory receptor 13-like [KO:K04257]
123830978  olfactory receptor 13-like [KO:K04257]
123830979  olfactory receptor 2A25-like [KO:K04257]
123830980  olfactory receptor 2A25-like [KO:K04257]
123830981  olfactory receptor 2A25-like [KO:K04257]
123830982  olfactory receptor 2A5-like [KO:K04257]
123830983  olfactory receptor 2A25-like [KO:K04257]
123830984  olfactory receptor 13-like [KO:K04257]
123830985  olfactory receptor 13-like [KO:K04257]
123830986  olfactory receptor 13-like [KO:K04257]
123830987  olfactory receptor 13-like [KO:K04257]
123830988  olfactory receptor 13-like [KO:K04257]
123830992  olfactory receptor-like protein OLF3 [KO:K04257]
123830993  olfactory receptor-like protein OLF3 [KO:K04257]
123830994  olfactory receptor-like protein OLF3 [KO:K04257]
123830997  olfactory receptor-like protein OLF3 [KO:K04257]
123831002  olfactory receptor 2F1-like [KO:K04257]
123809334  olfactory receptor-like protein DTMT [KO:K04257]
123809344  olfactory receptor-like protein DTMT [KO:K04257]
123809345  olfactory receptor-like protein DTMT [KO:K04257]
123809367  olfactory receptor 3A2 [KO:K04257]
123809368  olfactory receptor 3A1-like [KO:K04257]
123809369  olfactory receptor 3A1 [KO:K04257]
123809487  LOW QUALITY PROTEIN: olfactory receptor 139-like [KO:K04257]
123809488  olfactory receptor 1L4 [KO:K04257]
123816727  olfactory receptor 10AG1-like [KO:K04257]
123816731  olfactory receptor 10AG1-like [KO:K04257]
123816736  olfactory receptor 1052-like [KO:K04257]
123816744  olfactory receptor 1044-like [KO:K04257]
123816748  olfactory receptor 1052-like [KO:K04257]
123816755  olfactory receptor 1020-like [KO:K04257]
123816764  olfactory receptor 1052-like [KO:K04257]
123816772  olfactory receptor 1052-like [KO:K04257]
123816792  olfactory receptor 1052-like [KO:K04257]
123816801  LOW QUALITY PROTEIN: olfactory receptor 1020-like [KO:K04257]
123816803  olfactory receptor 1G1 [KO:K04257]
123816807  olfactory receptor 4A15-like [KO:K04257]
123816814  olfactory receptor 10AG1-like [KO:K04257]
123816891  olfactory receptor 6-like [KO:K04257]
123816902  LOW QUALITY PROTEIN: olfactory receptor 2AG2-like [KO:K04257]
123816925  olfactory receptor 2AG2-like [KO:K04257]
123816929  olfactory receptor 6 [KO:K04257]
123816938  LOW QUALITY PROTEIN: olfactory receptor 10A2-like [KO:K04257]
123831401  olfactory receptor 5AS1-like [KO:K04257]
123831404  putative olfactory receptor 2B8 [KO:K04257]
123831412  LOW QUALITY PROTEIN: olfactory receptor 5AS1-like [KO:K04257]
123831413  olfactory receptor 1052-like [KO:K04257]
123831419  olfactory receptor 5T2-like [KO:K04257]
123831420  olfactory receptor 8J2-like [KO:K04257]
123831422  olfactory receptor 8J2-like [KO:K04257]
123831423  olfactory receptor 5T2-like [KO:K04257]
123831424  LOW QUALITY PROTEIN: olfactory receptor 8J2-like [KO:K04257]
123831425  olfactory receptor 8K3-like [KO:K04257]
123831426  olfactory receptor 8K5-like [KO:K04257]
123831428  LOW QUALITY PROTEIN: olfactory receptor 8U1-like [KO:K04257]
123831429  olfactory receptor 5M3 [KO:K04257]
123831431  olfactory receptor 1030 [KO:K04257]
123831432  olfactory receptor 1020-like [KO:K04257]
123831433  olfactory receptor 5AP2 [KO:K04257]
123831435  olfactory receptor 1013-like [KO:K04257]
123831437  olfactory receptor 1013-like [KO:K04257]
123831443  olfactory receptor 10Q1 [KO:K04257]
123831444  olfactory receptor 5B3-like [KO:K04257]
123831445  olfactory receptor 5B3-like [KO:K04257]
123831446  olfactory receptor 5B3-like [KO:K04257]
123831449  olfactory receptor 8K1 [KO:K04257]
123831450  olfactory receptor 5M11-like [KO:K04257]
123831451  olfactory receptor 1030-like [KO:K04257]
123831453  olfactory receptor 5AK2-like [KO:K04257]
123831454  putative olfactory receptor 5AK3 [KO:K04257]
123831456  olfactory receptor 1038-like [KO:K04257]
123831457  LOW QUALITY PROTEIN: olfactory receptor 1038-like [KO:K04257]
123831459  olfactory receptor 8J1-like [KO:K04257]
123831460  olfactory receptor 8K3-like [KO:K04257]
123831461  olfactory receptor 5M8 [KO:K04257]
123831463  olfactory receptor 5M8-like [KO:K04257]
123831464  LOW QUALITY PROTEIN: olfactory receptor 5B12-like [KO:K04257]
123831466  olfactory receptor 1044 [KO:K04257]
123831468  olfactory receptor 5B3-like [KO:K04257]
123831469  olfactory receptor 5M11 [KO:K04257]
123831470  olfactory receptor 5B2-like [KO:K04257]
123831472  olfactory receptor 5M9 [KO:K04257]
123831473  LOW QUALITY PROTEIN: olfactory receptor 1030-like [KO:K04257]
123831474  olfactory receptor 5B2-like [KO:K04257]
123831475  olfactory receptor 5T2-like [KO:K04257]
123831476  olfactory receptor 5T2-like [KO:K04257]
123831478  olfactory receptor 1030-like [KO:K04257]
123831480  olfactory receptor 5M11-like [KO:K04257]
123831481  olfactory receptor 1030-like [KO:K04257]
123831482  olfactory receptor 5M10-like [KO:K04257]
123831484  olfactory receptor 5M10-like [KO:K04257]
123831485  olfactory receptor 1009-like [KO:K04257]
123831489  olfactory receptor 5AL1-like [KO:K04257]
123831490  olfactory receptor 5AL1-like [KO:K04257]
123831492  olfactory receptor 5T2-like [KO:K04257]
123831493  olfactory receptor 1086-like [KO:K04257]
123831494  olfactory receptor 1002-like [KO:K04257]
123831495  olfactory receptor 1094-like [KO:K04257]
123831496  olfactory receptor 1094-like [KO:K04257]
123831498  olfactory receptor 5T2-like [KO:K04257]
123831499  olfactory receptor 5T2-like [KO:K04257]
123831500  olfactory receptor 9Q1 [KO:K04257]
123831501  olfactory receptor 1052-like [KO:K04257]
123831502  olfactory receptor 9I1-like [KO:K04257]
123831506  olfactory receptor 1019 [KO:K04257]
123831507  olfactory receptor 1052-like [KO:K04257]
123831509  olfactory receptor 9Q2-like [KO:K04257]
123831513  olfactory receptor 8H1-like [KO:K04257]
123831514  olfactory receptor 8H1-like [KO:K04257]
123831516  olfactory receptor 8H1-like [KO:K04257]
123831517  olfactory receptor 8H1-like [KO:K04257]
123831518  olfactory receptor 8H1-like [KO:K04257]
123831522  olfactory receptor 8H1-like [KO:K04257]
123831524  olfactory receptor 1S1-like [KO:K04257]
123831526  olfactory receptor 476-like [KO:K04257]
123831527  olfactory receptor 5J2-like [KO:K04257]
123831528  olfactory receptor 6Q1 [KO:K04257]
123831529  olfactory receptor 10W1 [KO:K04257]
123809489  olfactory receptor-like protein DTMT [KO:K04257]
123809889  olfactory receptor 4S1 [KO:K04257]
123809938  olfactory receptor 4A5-like [KO:K04257]
123809939  olfactory receptor 4A5-like [KO:K04257]
123809941  olfactory receptor 4A5-like [KO:K04257]
123816949  olfactory receptor 10A4 [KO:K04257]
123816954  olfactory receptor 2D2-like [KO:K04257]
123816959  olfactory receptor 2D3 [KO:K04257]
123816966  olfactory receptor 226 [KO:K04257]
123816973  olfactory receptor 2D3-like [KO:K04257]
123831763  olfactory receptor 1P1-like [KO:K04257]
123810076  olfactory receptor 4C12-like [KO:K04257]
123810092  olfactory receptor 4A15-like [KO:K04257]
123810093  olfactory receptor 4A5-like [KO:K04257]
123810099  olfactory receptor 4A5-like [KO:K04257]
123810104  olfactory receptor 4A5-like [KO:K04257]
123810112  LOW QUALITY PROTEIN: olfactory receptor 4C3 [KO:K04257]
123810113  olfactory receptor 4C12-like [KO:K04257]
123810117  olfactory receptor 4A5-like [KO:K04257]
123810119  olfactory receptor 4C12-like [KO:K04257]
123810135  olfactory receptor 4X2-like [KO:K04257]
123810156  olfactory receptor 1030-like [KO:K04257]
123810158  olfactory receptor 4X1-like [KO:K04257]
123810176  olfactory receptor 10A3 [KO:K04257]
123810179  olfactory receptor 10A3-like [KO:K04257]
123810188  olfactory receptor 480 [KO:K04257]
123817476  LOW QUALITY PROTEIN: olfactory receptor 4D1-like [KO:K04257]
123817486  olfactory receptor 4D2-like [KO:K04257]
123817503  olfactory receptor 1D2-like [KO:K04257]
123817504  olfactory receptor 1D2-like [KO:K04257]
123817692  olfactory receptor 1A1 [KO:K04257]
123825006  olfactory receptor 5F1-like [KO:K04257]
123825022  olfactory receptor 5F1-like [KO:K04257]
123832169  olfactory receptor 2A12-like [KO:K04257]
123832170  olfactory receptor 2D2-like [KO:K04257]
123832178  olfactory receptor 2A12-like [KO:K04257]
123832188  olfactory receptor 2A12-like [KO:K04257]
123832189  olfactory receptor 2G3-like [KO:K04257]
123832200  olfactory receptor 2A12-like [KO:K04257]
123832430  olfactory receptor 1020-like [KO:K04257]
123832432  olfactory receptor 5W2-like [KO:K04257]
123832433  olfactory receptor 5L1-like [KO:K04257]
123832434  olfactory receptor 5L1-like [KO:K04257]
123832436  olfactory receptor 5L1-like [KO:K04257]
123832437  olfactory receptor 5L1-like [KO:K04257]
123832438  LOW QUALITY PROTEIN: olfactory receptor 5D18-like [KO:K04257]
123832439  olfactory receptor 1009-like [KO:K04257]
123832440  olfactory receptor 1009-like [KO:K04257]
123832444  olfactory receptor 4P4-like [KO:K04257]
123832446  LOW QUALITY PROTEIN: olfactory receptor 4S2-like [KO:K04257]
123832447  olfactory receptor 4C16-like [KO:K04257]
123832449  olfactory receptor 4P4-like [KO:K04257]
123832451  LOW QUALITY PROTEIN: olfactory receptor 4S2-like [KO:K04257]
123832453  LOW QUALITY PROTEIN: olfactory receptor 140-like [KO:K04257]
123832456  olfactory receptor 4A5-like [KO:K04257]
123832457  olfactory receptor 4A5-like [KO:K04257]
123832458  olfactory receptor 4A5-like [KO:K04257]
123832459  olfactory receptor 4C15-like [KO:K04257]
123832460  olfactory receptor 4A5-like [KO:K04257]
123832461  olfactory receptor 4A5-like [KO:K04257]
123832462  olfactory receptor 4C15-like [KO:K04257]
123832463  olfactory receptor 4A15-like isoform X1 [KO:K04257]
123832465  olfactory receptor 4A5-like [KO:K04257]
123832467  olfactory receptor 4A5-like [KO:K04257]
123832468  olfactory receptor 5L1-like [KO:K04257]
123832469  olfactory receptor 4C15-like [KO:K04257]
123832470  olfactory receptor 5L1-like [KO:K04257]
123832472  olfactory receptor 5D14 [KO:K04257]
123832473  olfactory receptor 4C16-like [KO:K04257]
123832474  olfactory receptor 1009-like [KO:K04257]
123832475  olfactory receptor 1009-like [KO:K04257]
123832478  olfactory receptor 6M1-like [KO:K04257]
123825893  olfactory receptor 1052-like [KO:K04257]
123825894  olfactory receptor 8U9-like [KO:K04257]
123825895  olfactory receptor 1052-like [KO:K04257]
123832516  olfactory receptor 958-like [KO:K04257]
123832517  olfactory receptor 149-like [KO:K04257]
123832519  olfactory receptor 149-like [KO:K04257]
123832520  LOW QUALITY PROTEIN: olfactory receptor 148-like [KO:K04257]
123832522  olfactory receptor 10S1 [KO:K04257]
123832523  olfactory receptor 6T1 [KO:K04257]
123832570  LOW QUALITY PROTEIN: olfactory receptor 8B12 [KO:K04257]
123832572  LOW QUALITY PROTEIN: olfactory receptor 8A1-like [KO:K04257]
123832580  olfactory receptor 151 [KO:K04257]
123832591  olfactory receptor 149-like [KO:K04257]
123832592  olfactory receptor 149-like [KO:K04257]
123832604  olfactory receptor 10G6 [KO:K04257]
123832626  olfactory receptor 6M1-like [KO:K04257]
123832441  olfactory receptor 5D13-like [KO:K04257]
123832442  LOW QUALITY PROTEIN: olfactory receptor 5D13-like [KO:K04257]
123828571  olfactory receptor 1361-like [KO:K04257]
123826403  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
123832310  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
123813731  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
123825394  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
123822448  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
123807045  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
123819322  CNGA4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
123805709  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
123810622  ANO2; anoctamin-2 isoform X1 [KO:K19497]
123805339  LOW QUALITY PROTEIN: guanylate cyclase D-like [KO:K12321] [EC:4.6.1.2]
123809404  GUCY2D; retinal guanylyl cyclase 1 isoform X1 [KO:K12321] [EC:4.6.1.2]
123811684  CNGA3; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
123833285  NCALD; neurocalcin-delta [KO:K19695]
123828671  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
123831363  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
123811770  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
123823061  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
123808746  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
123808854  SLC24A4; sodium/potassium/calcium exchanger 4 isoform X1 [KO:K13752]
123820806  GRK3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
123829489  GRK2; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
123805290  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
123809193  ARRB2; beta-arrestin-2 [KO:K04439]
123832970  RGS2; regulator of G-protein signaling 2 [KO:K18154]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123811379  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123813723  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123821027  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123806400  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
123811737  CALM2; calmodulin-2 [KO:K02183]
123821009  calmodulin-1-like [KO:K02183]
123808002  CALM1; calmodulin-1 [KO:K02183]
123808036  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
123823025  CALM3; calmodulin-3 [KO:K02183]
123831226  CALML3; calmodulin-like protein 3 [KO:K02183]
123831240  calmodulin-like [KO:K02183]
123831845  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
123811380  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
123812987  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
123808500  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
123805421  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
Compound
C00020  AMP
C00076  Calcium cation
C00144  GMP
C00238  Potassium cation
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00942  3',5'-Cyclic GMP
C01330  Sodium cation
Reference
PMID:20145624
  Authors
Kaupp UB
  Title
Olfactory signalling in vertebrates and insects: differences and commonalities.
  Journal
Nat Rev Neurosci 11:188-200 (2010)
DOI:10.1038/nrn2789
Reference
PMID:24733839
  Authors
Peterlin Z, Firestein S, Rogers ME
  Title
The state of the art of odorant receptor deorphanization: a report from the orphanage.
  Journal
J Gen Physiol 143:527-42 (2014)
DOI:10.1085/jgp.201311151
Reference
PMID:19652915
  Authors
Kato A, Touhara K
  Title
Mammalian olfactory receptors: pharmacology, G protein coupling and desensitization.
  Journal
Cell Mol Life Sci 66:3743-53 (2009)
DOI:10.1007/s00018-009-0111-6
Reference
PMID:11557990
  Authors
Firestein S.
  Title
How the olfactory system makes sense of scents.
  Journal
Nature 413:211-8 (2001)
DOI:10.1038/35093026
Reference
PMID:16269360
  Authors
Ache BW, Young JM.
  Title
Olfaction: diverse species, conserved principles.
  Journal
Neuron 48:417-30 (2005)
DOI:10.1016/j.neuron.2005.10.022
Reference
PMID:10944513
  Authors
Zufall F, Leinders-Zufall T.
  Title
The cellular and molecular basis of odor adaptation.
  Journal
Chem Senses 25:473-81 (2000)
DOI:10.1093/chemse/25.4.473
Reference
PMID:22875451
  Authors
Lodovichi C, Belluscio L
  Title
Odorant receptors in the formation of the olfactory bulb circuitry.
  Journal
Physiology (Bethesda) 27:200-12 (2012)
DOI:10.1152/physiol.00015.2012
Reference
PMID:12488531
  Authors
Kohout TA, Lefkowitz RJ.
  Title
Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization.
  Journal
Mol Pharmacol 63:9-18 (2003)
DOI:10.1124/mol.63.1.9
Reference
PMID:22735517
  Authors
De Palo G, Boccaccio A, Miri A, Menini A, Altafini C
  Title
A dynamical feedback model for adaptation in the olfactory transduction pathway.
  Journal
Biophys J 102:2677-86 (2012)
DOI:10.1016/j.bpj.2012.04.040
Reference
PMID:19941039
  Authors
Zufall F, Munger SD
  Title
Receptor guanylyl cyclases in mammalian olfactory function.
  Journal
Mol Cell Biochem 334:191-7 (2010)
DOI:10.1007/s11010-009-0325-9
Reference
PMID:19306880
  Authors
Duda T, Sharma RK
  Title
Ca2+-modulated ONE-GC odorant signal transduction.
  Journal
FEBS Lett 583:1327-30 (2009)
DOI:10.1016/j.febslet.2009.03.036
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pathway
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KO pathway
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