KEGG   PATHWAY: pmal03420
Entry
pmal03420                   Pathway                                
Name
Nucleotide excision repair - Plasmodium malariae
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
pmal03420  Nucleotide excision repair
pmal03420

Other DBs
GO: 0006289
Organism
Plasmodium malariae [GN:pmal]
Gene
PMUG01_08037000  RBX1; E3 ubiquitin-protein ligase RBX1, putative [KO:K03868] [EC:2.3.2.32]
PMUG01_08027700  RAD23; DNA repair protein RAD23, putative [KO:K10839]
PMUG01_08037900  RPB1; DNA-directed RNA polymerase II subunit RPB1, putative [KO:K03006] [EC:2.7.7.6]
PMUG01_04016700  RPB2; DNA-directed RNA polymerase II subunit RPB2, putative [KO:K03010] [EC:2.7.7.6]
PMUG01_07034500  DNA-directed RNA polymerase II subunit RPB3, putative [KO:K03011]
PMUG01_04026900  DNA-directed RNA polymerase II 16 kDa subunit, putative [KO:K03012]
PMUG01_11021400  RPB5; DNA-directed RNA polymerases I, II, and III subunit RPABC1, putative [KO:K03013]
PMUG01_08052900  RPB6; DNA-directed RNA polymerases I, II, and III subunit RPABC2, putative [KO:K03014]
PMUG01_10038600  RPB7; DNA-directed RNA polymerase II subunit RPB7, putative [KO:K03015]
PMUG01_14048500  RPB8; DNA-directed RNA polymerases I, II, and III subunit RPABC3, putative [KO:K03016]
PMUG01_02013600  RPB9; DNA-directed RNA polymerase II subunit RPB9, putative [KO:K03017]
PMUG01_01019700  RPB10; DNA-directed RNA polymerases I, II, and III subunit RPABC5, putative [KO:K03007]
PMUG01_12022200  DNA-directed RNA polymerases I, II, and III subunit RPABC4, putative [KO:K03009]
PMUG01_14021600  RPB11; DNA-directed RNA polymerase II subunit RPB11, putative [KO:K03008]
PMUG01_08030400  MRK; MO15-related protein kinase, putative [KO:K02202] [EC:2.7.11.22 2.7.11.23]
PMUG01_10032400  MAT1; CDK-activating kinase assembly factor, putative [KO:K10842]
PMUG01_12053200  CYC1; cyclin homologue, putative [KO:K06634]
PMUG01_10048400  DNA repair helicase RAD25, putative [KO:K10843] [EC:5.6.2.4]
PMUG01_07045900  XPD; TFIIH basal transcription factor complex helicase XPD subunit, putative [KO:K10844] [EC:5.6.2.3]
PMUG01_12075100  RNA polymerase II transcription factor B subunit 5, putative [KO:K10845]
PMUG01_14031600  general transcription factor IIH subunit 2, putative [KO:K03142]
PMUG01_11032300  TFB4; RNA polymerase II transcription factor B subunit 4, putative [KO:K03143]
PMUG01_04026400  RAD2; DNA repair protein RAD2, putative [KO:K10846]
PMUG01_03019600  RPA1; replication protein A1, large subunit, putative [KO:K07466]
PMUG01_12074900  replication factor A protein 3, putative [KO:K10740]
PMUG01_04029100  ERCC1; ERCC1 nucleotide excision repair protein, putative [KO:K10849]
PMUG01_00051100  DNA polymerase delta catalytic subunit, putative [KO:K02327] [EC:2.7.7.7]
PMUG01_08048200  DNA polymerase delta small subunit, putative [KO:K02328]
PMUG01_11033300  DNA polymerase epsilon catalytic subunit A, putative [KO:K02324] [EC:2.7.7.7]
PMUG01_14068500  DNA polymerase epsilon subunit B, putative [KO:K02325] [EC:2.7.7.7]
PMUG01_11024200  PCNA1; proliferating cell nuclear antigen 1, putative [KO:K04802]
PMUG01_14060900  PCNA2; proliferating cell nuclear antigen 2, putative [KO:K04802]
PMUG01_04012800  RFC1; replication factor C subunit 1, putative [KO:K10754]
PMUG01_04014400  RFC2; replication factor C subunit 2, putative [KO:K10755]
PMUG01_14074900  RFC4; replication factor C subunit 4, putative [KO:K10755]
PMUG01_09020600  RFC5; replication factor C subunit 5, putative [KO:K10756]
PMUG01_12053700  RFC3; replication factor C subunit 3, putative [KO:K10756]
PMUG01_14020700  DNA ligase I, putative [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
pmal03020  RNA polymerase
pmal04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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