KEGG   PATHWAY: pmud00061
Entry
pmud00061                   Pathway                                
Name
Fatty acid biosynthesis - Pseudomonas mucidolens
Class
Metabolism; Lipid metabolism
Pathway map
pmud00061  Fatty acid biosynthesis
pmud00061

Module
pmud_M00082  Fatty acid biosynthesis, initiation [PATH:pmud00061]
pmud_M00083  Fatty acid biosynthesis, elongation [PATH:pmud00061]
pmud_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:pmud00061]
Other DBs
GO: 0006633
Organism
Pseudomonas mucidolens [GN:pmud]
Gene
NCTC8068_01199  accA; acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
NCTC8068_00620  accB; acetyl-CoA carboxylase, biotin carboxyl carrier protein [KO:K02160]
NCTC8068_00619  accC_2; acetyl-CoA carboxylase, biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
NCTC8068_03450  accD; acetyl-CoA carboxylase [KO:K01963] [EC:6.4.1.2 2.1.3.15]
NCTC8068_01459  fabD_1; malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
NCTC8068_03806  fabH_1; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
NCTC8068_03703  fabB; beta-ketoacyl-ACP synthase I [KO:K00647] [EC:2.3.1.41]
NCTC8068_00437  fabF_2; 3-oxoacyl-(acyl carrier protein) synthase I [KO:K00647] [EC:2.3.1.41]
NCTC8068_01462  fabF_3; 3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
NCTC8068_02378  fabF_4; beta-ketoacyl-ACP synthase I [KO:K09458] [EC:2.3.1.179]
NCTC8068_00434  fabF_1; 3-oxoacyl-ACP synthase [KO:K09458] [EC:2.3.1.179]
NCTC8068_01460  fabG_6; 3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_01550  fabG_7; short chain dehydrogenase/reductase family oxidoreductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_02400  fabG_14; short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
NCTC8068_02439  fabG_15; 3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_02798  fabG_17; 3-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_03338  fabG_20; short-chain dehydrogenase/reductase SDR [KO:K00059] [EC:1.1.1.100]
NCTC8068_00178  fabG_1; short-chain dehydrogenase [KO:K00059] [EC:1.1.1.100]
NCTC8068_00435  fabG_4; 3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_00639  fabG_5; 3-ketoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_04273  fabG_24; 3-oxoacyl-ACP reductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_04274  oxidoreductase [KO:K00059] [EC:1.1.1.100]
NCTC8068_03702  fabA; 3-hydroxydecanoyl-ACP dehydratase [KO:K01716] [EC:4.2.1.59 5.3.3.14]
NCTC8068_01193  fabZ; (3R)-hydroxymyristoyl-ACP dehydratase [KO:K02372] [EC:4.2.1.59]
NCTC8068_03521  short-chain alcohol dehydrogenase family protein [KO:K00209] [EC:1.3.1.9 1.3.1.44]
NCTC8068_02794  fadD_1; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
NCTC8068_03695  putative AMP-binding protein [KO:K01897] [EC:6.2.1.3]
NCTC8068_04008  fadD1; acyl-CoA synthetase [KO:K01897] [EC:6.2.1.3]
NCTC8068_04009  fadD_3; long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
PMID:12061798
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
PMID:12518017
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
PMID:11337402
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
PMID:17573542
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
PMID:30201289
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
PMID:25203508
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
PMID:19686777
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
PMID:27553474
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
pmud00020  Citrate cycle (TCA cycle)
pmud00071  Fatty acid degradation
pmud00410  beta-Alanine metabolism
pmud00561  Glycerolipid metabolism
pmud00564  Glycerophospholipid metabolism
pmud00620  Pyruvate metabolism
pmud00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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