Entry Name Mineral absorption - Pongo abelii (Sumatran orangutan)
Description Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium.
Class Organismal Systems; Digestive systemBRITE hierarchy
Pathway map Ortholog table Organism Pongo abelii (Sumatran orangutan) [GN:
pon ]
Gene 100436382 SLC34A1; sodium-dependent phosphate transport protein 2A isoform X1 [KO:K14683 ]
100171622 SLC34A2; sodium-dependent phosphate transport protein 2B [KO:K14683 ]
100440722 SLC34A3; sodium-dependent phosphate transport protein 2C [KO:K14683 ]
100449302 TRPM6; transient receptor potential cation channel subfamily M member 6 isoform X1 [KO:K04981 ] [EC:2.7.11.1 ]
100437453 TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982 ] [EC:2.7.11.1 ]
100444612 TRPV6; transient receptor potential cation channel subfamily V member 6 [KO:K04975 ]
100173524 SLC6A19; sodium-dependent neutral amino acid transporter B(0)AT1 [KO:K05334 ]
100434842 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540 ]
100447776 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
100173011 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
103891919 sodium/potassium-transporting ATPase subunit gamma isoform X1
100434194 SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398 ]
100446225 STEAP1; metalloreductase STEAP1 isoform X2 [KO:K14737 ] [EC:1.16.1.-]
100939813 STEAP2; metalloreductase STEAP2 isoform X1 [KO:K14738 ] [EC:1.16.1.-]
Compound Reference Authors Perez AV, Picotto G, Carpentieri AR, Rivoira MA, Peralta Lopez ME, Tolosa de Talamoni NG
Title Minireview on regulation of intestinal calcium absorption. Emphasis on molecular mechanisms of transcellular pathway.
Journal Reference Authors Khanal RC, Nemere I
Title Regulation of intestinal calcium transport.
Journal Reference Authors Hoenderop JG, Nilius B, Bindels RJ
Title Calcium absorption across epithelia.
Journal Reference Authors Bouillon R, Van Cromphaut S, Carmeliet G
Title Intestinal calcium absorption: Molecular vitamin D mediated mechanisms.
Journal Reference Authors Chua AC, Graham RM, Trinder D, Olynyk JK
Title The regulation of cellular iron metabolism.
Journal Reference Authors West AR, Oates PS
Title Mechanisms of heme iron absorption: current questions and controversies.
Journal Reference Authors Dunn LL, Rahmanto YS, Richardson DR
Title Iron uptake and metabolism in the new millennium.
Journal Reference Authors Donovan A, Roy CN, Andrews NC
Title The ins and outs of iron homeostasis.
Journal Reference Authors Lonnerdal B
Title Intestinal regulation of copper homeostasis: a developmental perspective.
Journal Reference Authors Prohaska JR
Title Role of copper transporters in copper homeostasis.
Journal Reference Authors Wang X, Zhou B
Title Dietary zinc absorption: A play of Zips and ZnTs in the gut.
Journal Reference Authors Lichten LA, Cousins RJ
Title Mammalian zinc transporters: nutritional and physiologic regulation.
Journal Reference Authors Quamme GA
Title Recent developments in intestinal magnesium absorption.
Journal Reference Authors Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X
Title NHE3 regulatory complexes.
Journal Reference Authors Kato A, Romero MF
Title Regulation of Electroneutral NaCl Absorption by the Small Intestine.
Journal Reference Authors Sabbagh Y, O'Brien SP, Song W, Boulanger JH, Stockmann A, Arbeeny C, Schiavi SC
Title Intestinal npt2b plays a major role in phosphate absorption and homeostasis.
Journal Reference Authors Marks J, Srai SK, Biber J, Murer H, Unwin RJ, Debnam ES
Title Intestinal phosphate absorption and the effect of vitamin D: a comparison of rats with mice.
Journal Related pon04973 Carbohydrate digestion and absorption
pon04974 Protein digestion and absorption
KO pathway LinkDB All DBs
