KEGG   PATHWAY: pow00030
Entry
pow00030                    Pathway                                
Name
Pentose phosphate pathway - Paenibacillus sp. 32O-W
Description
The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathway. One is irreversible oxidative phase in which glucose-6P is converted to ribulose-5P by oxidative decarboxylation, and NADPH is generated [MD:M00006]. The other is reversible non-oxidative phase in which phosphorylated sugars are interconverted to generate xylulose-5P, ribulose-5P, and ribose-5P [MD:M00007]. Phosphoribosyl pyrophosphate (PRPP) formed from ribose-5P [MD:M00005] is an activated compound used in the biosynthesis of histidine and purine/pyrimidine nucleotides. This pathway map also shows the Entner-Doudoroff pathway where 6-P-gluconate is dehydrated and then cleaved into pyruvate and glyceraldehyde-3P [MD:M00008].
Class
Metabolism; Carbohydrate metabolism
Pathway map
pow00030  Pentose phosphate pathway
pow00030

Module
pow_M00004  Pentose phosphate pathway (Pentose phosphate cycle) [PATH:pow00030]
pow_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pow00030]
pow_M00006  Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P [PATH:pow00030]
pow_M00007  Pentose phosphate pathway, non-oxidative phase, fructose 6P => ribose 5P [PATH:pow00030]
pow_M00345  Formaldehyde assimilation, ribulose monophosphate pathway [PATH:pow00030]
pow_M00631  D-Galacturonate degradation (bacteria), D-galacturonate => pyruvate + D-glyceraldehyde 3P [PATH:pow00030]
Other DBs
GO: 0006098
Organism
Paenibacillus sp. 32O-W [GN:pow]
Gene
IJ21_41260  glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
IJ21_41900  glucose-6-phosphate dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
IJ21_08260  glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
IJ21_44360  6-phosphogluconolactonase [KO:K07404] [EC:3.1.1.31]
IJ21_20220  6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
IJ21_08270  6-phosphogluconate dehydrogenase [KO:K00033] [EC:1.1.1.44 1.1.1.343]
IJ21_20790  ribulose-phosphate 3-epimerase [KO:K01783] [EC:5.1.3.1]
IJ21_31790  transketolase [KO:K00615] [EC:2.2.1.1]
IJ21_31800  transketolase [KO:K00615] [EC:2.2.1.1]
IJ21_41290  transketolase [KO:K00615] [EC:2.2.1.1]
IJ21_00780  transketolase [KO:K00615] [EC:2.2.1.1]
IJ21_41630  fructose-6-phosphate aldolase [KO:K00616] [EC:2.2.1.2]
IJ21_16720  fructose-6-phosphate aldolase [KO:K00616] [EC:2.2.1.2]
IJ21_00790  fructose-6-phosphate aldolase [KO:K00616] [EC:2.2.1.2]
IJ21_05790  ribose 5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
IJ21_26300  ribose 5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
IJ21_00830  ribose 5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
IJ21_01170  ribose 5-phosphate isomerase [KO:K01808] [EC:5.3.1.6]
IJ21_08240  3-hexulose-6-phosphate synthase [KO:K08093] [EC:4.1.2.43]
IJ21_08250  6-phospho 3-hexuloisomerase [KO:K08094] [EC:5.3.1.27]
IJ21_18800  deoxyribose-phosphate aldolase [KO:K01619] [EC:4.1.2.4]
IJ21_01190  ribokinase [KO:K00852] [EC:2.7.1.15]
IJ21_08810  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
IJ21_06310  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
IJ21_24820  phosphoglucosamine mutase [KO:K15778] [EC:5.4.2.8 5.4.2.2]
IJ21_08880  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
IJ21_01730  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
IJ21_47110  ketohydroxyglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
IJ21_44110  2-dehydro-3-deoxyphosphogluconate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
IJ21_13280  short-chain dehydrogenase [KO:K00034] [EC:1.1.1.47]
IJ21_12140  3-ketoacyl-ACP reductase [KO:K00034] [EC:1.1.1.47]
IJ21_45200  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
IJ21_20210  gluconokinase [KO:K25031] [EC:2.7.1.12]
IJ21_15040  2-dehydro-3-deoxygluconokinase [KO:K00874] [EC:2.7.1.45]
IJ21_02090  tagatose-bisphosphate aldolase [KO:K01624] [EC:4.1.2.13]
IJ21_26340  fructose 1,6-bisphosphatase [KO:K02446] [EC:3.1.3.11]
IJ21_41650  fructose 1,6-bisphosphatase [KO:K02446] [EC:3.1.3.11]
IJ21_00800  fructose 1,6-bisphosphatase [KO:K02446] [EC:3.1.3.11]
IJ21_35890  6-phosphofructokinase [KO:K00850] [EC:2.7.1.11]
Compound
C00022  Pyruvate
C00031  D-Glucose
C00085  D-Fructose 6-phosphate
C00117  D-Ribose 5-phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00121  D-Ribose
C00197  3-Phospho-D-glycerate
C00198  D-Glucono-1,5-lactone
C00199  D-Ribulose 5-phosphate
C00204  2-Dehydro-3-deoxy-D-gluconate
C00221  beta-D-Glucose
C00231  D-Xylulose 5-phosphate
C00257  D-Gluconic acid
C00258  D-Glycerate
C00279  D-Erythrose 4-phosphate
C00345  6-Phospho-D-gluconate
C00354  D-Fructose 1,6-bisphosphate
C00577  D-Glyceraldehyde
C00620  alpha-D-Ribose 1-phosphate
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C00672  2-Deoxy-D-ribose 1-phosphate
C00673  2-Deoxy-D-ribose 5-phosphate
C01151  D-Ribose 1,5-bisphosphate
C01172  beta-D-Glucose 6-phosphate
C01182  D-Ribulose 1,5-bisphosphate
C01218  6-Phospho-2-dehydro-D-gluconate
C01236  D-Glucono-1,5-lactone 6-phosphate
C01801  Deoxyribose
C02076  Sedoheptulose
C03752  2-Amino-2-deoxy-D-gluconate
C04442  2-Dehydro-3-deoxy-6-phospho-D-gluconate
C05382  Sedoheptulose 7-phosphate
C06019  D-arabino-Hex-3-ulose 6-phosphate
C06473  2-Keto-D-gluconic acid
C20589  D-Glucosaminate-6-phosphate
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Reference
  Authors
Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL.
  Title
Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.
  Journal
J Bacteriol 185:2793-801 (2003)
DOI:10.1128/JB.185.9.2793-2801.2003
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
Reference
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
  Authors
Kouril T, Wieloch P, Reimann J, Wagner M, Zaparty M, Albers SV, Schomburg D, Ruoff P, Siebers B
  Title
Unraveling the function of the two Entner-Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2.
  Journal
FEBS J 280:1126-38 (2013)
DOI:10.1111/febs.12106
Reference
  Authors
Reher M, Schonheit P
  Title
Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily.
  Journal
FEBS Lett 580:1198-204 (2006)
DOI:10.1016/j.febslet.2006.01.029
Reference
  Authors
Reher M, Fuhrer T, Bott M, Schonheit P
  Title
The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase.
  Journal
J Bacteriol 192:964-74 (2010)
DOI:10.1128/JB.01281-09
Related
pathway
pow00010  Glycolysis / Gluconeogenesis
pow00040  Pentose and glucuronate interconversions
pow00052  Galactose metabolism
pow00230  Purine metabolism
pow00240  Pyrimidine metabolism
pow00340  Histidine metabolism
pow00630  Glyoxylate and dicarboxylate metabolism
pow00750  Vitamin B6 metabolism
KO pathway
ko00030   
LinkDB

DBGET integrated database retrieval system