KEGG   PATHWAY: ppab00260
Entry
ppab00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Paenibacillus pabuli
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppab00260  Glycine, serine and threonine metabolism
ppab00260

Module
ppab_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppab00260]
ppab_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppab00260]
ppab_M00621  Glycine cleavage system [PATH:ppab00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Paenibacillus pabuli [GN:ppab]
Gene
KET34_22955  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KET34_12905  dapG; aspartate kinase [KO:K00928] [EC:2.7.2.4]
KET34_15050  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KET34_27645  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KET34_27635  homoserine kinase [KO:K00872] [EC:2.7.1.39]
KET34_12235  phosphotransferase [KO:K02204] [EC:2.7.1.39]
KET34_27640  threonine synthase [KO:K01733] [EC:4.2.3.1]
KET34_08105  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KET34_15775  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KET34_31410  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KET34_33465  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KET34_29960  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
KET34_09270  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
KET34_13385  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
KET34_14080  histidine phosphatase family protein [KO:K01834] [EC:5.4.2.11]
KET34_05665  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
KET34_17605  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
KET34_18545  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
KET34_02375  histidine phosphatase family protein [KO:K15634] [EC:5.4.2.11]
KET34_00925  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KET34_22340  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KET34_09790  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KET34_07835  histidine phosphatase family protein [KO:K22305] [EC:3.1.3.3]
KET34_21110  HAD family hydrolase [KO:K25528] [EC:3.1.3.3]
KET34_18450  glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
KET34_27170  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
KET34_27175  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
KET34_27165  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KET34_22770  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KET34_04310  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KET34_20905  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KET34_27160  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KET34_29985  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KET34_30815  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KET34_26140  solA; N-methyl-L-tryptophan oxidase [KO:K00301] [EC:1.5.3.1]
KET34_02470  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
KET34_02475  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
KET34_03970  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
KET34_04725  aspartate/glutamate racemase family protein [KO:K25316] [EC:5.1.1.10]
KET34_22105  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KET34_22110  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KET34_17550  succinylglutamate desuccinylase/aspartoacylase family protein [KO:K15784] [EC:3.5.1.125]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppab00010  Glycolysis / Gluconeogenesis
ppab00020  Citrate cycle (TCA cycle)
ppab00230  Purine metabolism
ppab00250  Alanine, aspartate and glutamate metabolism
ppab00270  Cysteine and methionine metabolism
ppab00290  Valine, leucine and isoleucine biosynthesis
ppab00300  Lysine biosynthesis
ppab00330  Arginine and proline metabolism
ppab00460  Cyanoamino acid metabolism
ppab00470  D-Amino acid metabolism
ppab00564  Glycerophospholipid metabolism
ppab00600  Sphingolipid metabolism
ppab00620  Pyruvate metabolism
ppab00630  Glyoxylate and dicarboxylate metabolism
ppab00640  Propanoate metabolism
ppab00680  Methane metabolism
ppab00860  Porphyrin metabolism
ppab00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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