KEGG   PATHWAY: pper00480
Entry
pper00480                   Pathway                                
Name
Glutathione metabolism - Prunus persica (peach)
Class
Metabolism; Metabolism of other amino acids
Pathway map
pper00480  Glutathione metabolism
pper00480

Module
pper_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:pper00480]
Other DBs
GO: 0006749
Organism
Prunus persica (peach) [GN:pper]
Gene
18772755  gamma-glutamyltranspeptidase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
18771318  gamma-glutamyltranspeptidase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
18790271  gamma-glutamylcyclotransferase 2-1 [KO:K22596] [EC:4.3.2.9]
18788851  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
18787387  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
18777994  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
18777525  glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
18772608  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
18769601  leucine aminopeptidase 1 [KO:K01255] [EC:3.4.11.1]
18776004  puromycin-sensitive aminopeptidase isoform X1 [KO:K01256] [EC:3.4.11.2]
18768007  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
18766651  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18767567  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
18766412  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18768411  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18766289  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18766418  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18766654  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
18780903  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18784753  protein IN2-1 homolog B [KO:K00799] [EC:2.5.1.18]
18785725  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18777459  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
18773560  glutathione S-transferase L3 [KO:K00799] [EC:2.5.1.18]
18777216  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
18775829  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
18775763  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
18779958  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18781117  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18776330  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
18779997  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18780231  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18779428  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18779399  probable glutathione S-transferase parC isoform X1 [KO:K00799] [EC:2.5.1.18]
18779787  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18779097  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18781725  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18786559  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18771969  glutathione S-transferase U8 [KO:K00799] [EC:2.5.1.18]
18776053  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18778000  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
18777736  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18783070  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
18782821  glutathione S-transferase F12 [KO:K00799] [EC:2.5.1.18]
18782598  glutathione S-transferase F9 [KO:K00799] [EC:2.5.1.18]
18774018  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
18775064  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18777460  glutathione S-transferase U9 [KO:K00799] [EC:2.5.1.18]
18779050  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18780458  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
18783675  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
18793472  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
18791020  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18793511  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
109949092  LOW QUALITY PROTEIN: glutathione S-transferase U10-like [KO:K00799] [EC:2.5.1.18]
18792583  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
18792449  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
18791296  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
18790968  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18767284  glutathione S-transferase F13 [KO:K00799] [EC:2.5.1.18]
18792586  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
18789994  glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18788369  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
18794033  probable glutathione S-transferase parA [KO:K00799] [EC:2.5.1.18]
109946244  glutathione S-transferase F9-like [KO:K00799] [EC:2.5.1.18]
18778800  probable glutathione S-transferase isoform X1 [KO:K00799] [EC:2.5.1.18]
18778816  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18766658  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
18787430  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
18784488  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
18766619  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
18791729  glutathione reductase, cytosolic isoform X1 [KO:K00383] [EC:1.8.1.7]
18782217  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
18779564  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
18781889  isocitrate dehydrogenase [NADP] isoform X1 [KO:K00031] [EC:1.1.1.42]
18783083  6-phosphogluconate dehydrogenase, decarboxylating 3 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
18775897  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
18772820  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
18781823  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
18783720  glucose-6-phosphate 1-dehydrogenase, cytoplasmic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
18790433  glucose-6-phosphate 1-dehydrogenase, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
109946232  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
18776398  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
18777404  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
18776536  probable phospholipid hydroperoxide glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
18788389  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
18793339  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
18790191  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
18766316  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
18785691  spermine synthase [KO:K00797] [EC:2.5.1.16]
18788330  spermidine synthase [KO:K00797] [EC:2.5.1.16]
18776857  spermidine synthase 2 isoform X1 [KO:K00797] [EC:2.5.1.16]
18768608  L-ascorbate peroxidase 3, peroxisomal isoform X2 [KO:K00434] [EC:1.11.1.11]
18772001  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
18774632  L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
18769065  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
18788446  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
109950245  L-ascorbate peroxidase 3, peroxisomal-like [KO:K00434] [EC:1.11.1.11]
18788761  probable L-ascorbate peroxidase 6, chloroplastic isoform X1 [KO:K00434] [EC:1.11.1.11]
18768453  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
18775452  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
18783959  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
18790174  ribonucleoside-diphosphate reductase small chain A isoform X3 [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
pper00220  Arginine biosynthesis
pper00250  Alanine, aspartate and glutamate metabolism
pper00270  Cysteine and methionine metabolism
pper00430  Taurine and hypotaurine metabolism
pper00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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