KEGG   PATHWAY: pxa00260
Entry
pxa00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas xanthosomatis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pxa00260  Glycine, serine and threonine metabolism
pxa00260

Module
pxa_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pxa00260]
pxa_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pxa00260]
pxa_M00555  Betaine biosynthesis, choline => betaine [PATH:pxa00260]
pxa_M00621  Glycine cleavage system [PATH:pxa00260]
pxa_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:pxa00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas xanthosomatis [GN:pxa]
Gene
KSS93_22030  aspartate kinase [KO:K00928] [EC:2.7.2.4]
KSS93_11330  asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
KSS93_23925  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
KSS93_01575  homoserine kinase [KO:K02204] [EC:2.7.1.39]
KSS93_23920  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
KSS93_00110  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
KSS93_25835  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KSS93_00105  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
KSS93_18885  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
KSS93_25390  2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
KSS93_07640  D-glycerate dehydrogenase [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
KSS93_17380  glycerate kinase [KO:K00865] [EC:2.7.1.165]
KSS93_21395  glycerate kinase [KO:K11529] [EC:2.7.1.165]
KSS93_03820  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
KSS93_12890  D-2-hydroxyacid dehydrogenase family protein [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS93_00755  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
KSS93_10350  serC; 3-phosphoserine/phosphohydroxythreonine transaminase [KO:K00831] [EC:2.6.1.52]
KSS93_04555  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
KSS93_19970  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
KSS93_04195  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
KSS93_24310  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KSS93_00980  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
KSS93_24320  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KSS93_00990  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
KSS93_20790  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS93_21960  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS93_02140  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
KSS93_24305  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS93_00985  gcvH; glycine cleavage system protein GcvH [KO:K02437]
KSS93_07150  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
KSS93_03785  betA; choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
KSS93_25615  aldehyde dehydrogenase family protein [KO:K00130] [EC:1.2.1.8]
KSS93_03790  betB; betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
KSS93_18900  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K00479] [EC:1.14.13.251]
KSS93_00140  gbcA; glycine-betaine demethylase subunit GbcA [KO:K00479] [EC:1.14.13.251]
KSS93_18905  hybrid-cluster NAD(P)-dependent oxidoreductase [KO:K21832] [EC:1.14.13.251]
KSS93_00135  gbcB; glycine-betaine demethylase subunit GbcB [KO:K21832] [EC:1.14.13.251]
KSS93_00165  dgcA; dimethylglycine demethylation protein DgcA [KO:K21833] [EC:1.5.7.3]
KSS93_00160  dgcB; dimethylglycine demethylation protein DgcB [KO:K21834]
KSS93_00155  electron transfer flavoprotein subunit alpha/FixB family protein [KO:K25960]
KSS93_00150  electron transfer flavoprotein subunit beta [KO:K25961]
KSS93_19185  (2Fe-2S)-binding protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
KSS93_00090  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
KSS93_19175  FAD-dependent oxidoreductase [KO:K00303] [EC:1.5.3.24 1.5.3.1]
KSS93_00100  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
KSS93_19190  sarcosine oxidase [KO:K00305] [EC:1.5.3.24 1.5.3.1]
KSS93_00085  sarcosine oxidase subunit gamma family protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
KSS93_19180  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
KSS93_00095  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
KSS93_22790  PLP-dependent aspartate aminotransferase family protein [KO:K01758] [EC:4.4.1.1]
KSS93_16500  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS93_24315  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS93_00260  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
KSS93_16350  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS93_22560  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
KSS93_00725  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
KSS93_14370  pyridoxal-phosphate dependent enzyme [KO:K17989] [EC:4.3.1.17 4.3.1.19]
KSS93_01775  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
KSS93_01770  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
KSS93_13480  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
KSS93_20935  aspartate aminotransferase family protein [KO:K00836] [EC:2.6.1.76]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pxa00010  Glycolysis / Gluconeogenesis
pxa00020  Citrate cycle (TCA cycle)
pxa00230  Purine metabolism
pxa00250  Alanine, aspartate and glutamate metabolism
pxa00270  Cysteine and methionine metabolism
pxa00290  Valine, leucine and isoleucine biosynthesis
pxa00300  Lysine biosynthesis
pxa00330  Arginine and proline metabolism
pxa00460  Cyanoamino acid metabolism
pxa00470  D-Amino acid metabolism
pxa00564  Glycerophospholipid metabolism
pxa00620  Pyruvate metabolism
pxa00630  Glyoxylate and dicarboxylate metabolism
pxa00640  Propanoate metabolism
pxa00680  Methane metabolism
pxa00860  Porphyrin metabolism
pxa00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

DBGET integrated database retrieval system