KEGG   PATHWAY: qsa00480
Entry
qsa00480                    Pathway                                
Name
Glutathione metabolism - Quillaja saponaria (soapbark tree)
Class
Metabolism; Metabolism of other amino acids
Pathway map
qsa00480  Glutathione metabolism
qsa00480

Module
qsa_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:qsa00480]
Other DBs
GO: 0006749
Organism
Quillaja saponaria (soapbark tree) [GN:qsa]
Gene
O6P43_030422  Gamma-glutamyltranspeptidase [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
O6P43_003936  Gamma-glutamyltranspeptidase [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
O6P43_019330  Gamma-glutamylcyclotransferase [KO:K22596] [EC:4.3.2.9]
O6P43_015198  Gamma-glutamylcyclotransferase [KO:K22596] [EC:4.3.2.9]
O6P43_015563  Gamma-glutamylcyclotransferase [KO:K22596] [EC:4.3.2.9]
O6P43_012416  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
O6P43_031654  5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
O6P43_034240  Glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
O6P43_024184  glutamate--cysteine ligase, chloroplastic-like [KO:K01919] [EC:6.3.2.2]
O6P43_024185  Glutamate--cysteine ligase, chloroplastic [KO:K01919] [EC:6.3.2.2]
O6P43_007558  Glutathione synthetase [KO:K21456] [EC:6.3.2.3]
O6P43_011140  Glutathione synthetase [KO:K21456] [EC:6.3.2.3]
O6P43_022195  putative Leucine aminopeptidase [KO:K01255] [EC:3.4.11.1]
O6P43_024161  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
O6P43_034233  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_007143  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_007147  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_007149  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_016320  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_016697  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_024158  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_024193  Glutathione S-transferase protein [KO:K00799] [EC:2.5.1.18]
O6P43_017255  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_035450  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_035451  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_017715  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_025389  Glutathione S-transferase family protein [KO:K00799] [EC:2.5.1.18]
O6P43_025390  Glutathione S-transferase family protein [KO:K00799] [EC:2.5.1.18]
O6P43_025459  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_026449  Glutathione S-transferase protein [KO:K00799] [EC:2.5.1.18]
O6P43_001161  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
O6P43_010743  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_010744  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_010745  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_010746  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_010747  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_010748  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_001952  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_018733  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
O6P43_029298  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_029300  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_029301  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_029302  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_029303  Glutathione S-transferase-like protein [KO:K00799] [EC:2.5.1.18]
O6P43_029304  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003102  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003103  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003104  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003105  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003107  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003108  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_019593  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_003545  Glutathione S-transferase family protein [KO:K00799] [EC:2.5.1.18]
O6P43_020453  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_020517  Microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
O6P43_031204  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014161  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014211  Microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
O6P43_014215  Microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
O6P43_014225  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014231  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_005145  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014757  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014761  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014762  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_022098  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_022099  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_022100  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_022842  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_022843  putative Glutathione s-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_033022  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_033080  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_033081  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_006724  Glutathione S-transferase family protein [KO:K00799] [EC:2.5.1.18]
O6P43_006726  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_006727  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_006729  Glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
O6P43_014301  Glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
O6P43_005722  Glutathione S-transferase [KO:K21888] [EC:1.8.5.1 2.5.1.18]
O6P43_034453  Glutathione reductase [KO:K00383] [EC:1.8.1.7]
O6P43_010561  glutathione reductase [KO:K00383] [EC:1.8.1.7]
O6P43_003036  Glutathione reductase [KO:K00383] [EC:1.8.1.7]
O6P43_022150  Glutathione reductase [KO:K00383] [EC:1.8.1.7]
O6P43_006954  glutathione reductase [KO:K00383] [EC:1.8.1.7]
O6P43_008937  Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
O6P43_029434  Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
O6P43_020542  Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
O6P43_004647  Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
O6P43_014244  Isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
O6P43_034307  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
O6P43_024005  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
O6P43_009224  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
O6P43_004340  6-phosphogluconate dehydrogenase, decarboxylating [KO:K00033] [EC:1.1.1.44 1.1.1.343]
O6P43_023818  Glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
O6P43_011005  Glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
O6P43_030622  Glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
O6P43_004766  Glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
O6P43_014470  glucose-6-phosphate dehydrogenase 1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
O6P43_034234  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_007067  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_024190  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_024191  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_010657  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_002499  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_019208  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_015779  Glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
O6P43_003728  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
O6P43_021918  1-Cys peroxiredoxin [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
O6P43_025315  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_019905  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_030891  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_015027  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_022730  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_033146  Spermidine synthase [KO:K00797] [EC:2.5.1.16]
O6P43_000279  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_010337  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_028320  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_002117  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_011462  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_019769  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_015163  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_015696  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_033593  Ascorbate peroxidase [KO:K00434] [EC:1.11.1.11]
O6P43_023312  Ribonucleoside-diphosphate reductase [KO:K10807] [EC:1.17.4.1]
O6P43_008765  putative Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
O6P43_003446  putative Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
O6P43_004869  Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
O6P43_021640  putative Ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
qsa00220  Arginine biosynthesis
qsa00250  Alanine, aspartate and glutamate metabolism
qsa00270  Cysteine and methionine metabolism
qsa00430  Taurine and hypotaurine metabolism
qsa00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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