KEGG   PATHWAY: reh00362
Entry
reh00362                    Pathway                                
Name
Benzoate degradation - Cupriavidus necator H16
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
reh00362  Benzoate degradation
reh00362

Module
reh_M00548  Benzene degradation, benzene => catechol [PATH:reh00362]
reh_M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:reh00362]
reh_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:reh00362]
reh_M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:reh00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Cupriavidus necator H16 [GN:reh]
Gene
H16_A1963  benA; Benzoate 1,2-dioxygenase hydroxylase component,alpha subunit [KO:K05549] [EC:1.14.12.10 1.14.12.-]
H16_A1962  benB; Benzoate 1,2-dioxygenase hydroxylase component,beta subunit [KO:K05550] [EC:1.14.12.10 1.14.12.-]
H16_A1961  benC; Benzoate 1,2-dioxygenase electron transfer component [KO:K05784] [EC:1.18.1.-]
H16_A1960  benD; Cis-1,2-dihydroxycyclohexa-3 5-diene-1-carboxylate dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
H16_A1964  catA; Catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
H16_A0633  pcaH2; Protocatechuate 3,4-dioxygenase beta subunit [KO:K03381] [EC:1.13.11.1]
H16_A1966  catB3; muconate cyclo-isomerase [KO:K01856] [EC:5.5.1.1]
H16_B0536  catB4; muconate cyclo-isomerase [KO:K01856] [EC:5.5.1.1]
PHG405  catB1; putative muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
PHG394  catB2; putative muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
H16_B1584  catC2; muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
H16_A1967  catC3; muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
PHG384  mmlJ; putative methylmuconolactone isomerase [KO:K03464] [EC:5.3.3.4]
PHG404  catC; putative muconolactone isomerase [KO:K03464] [EC:5.3.3.4]
H16_A0147  h16_A0147; predicted hydrolase or acyltransferase (alpha/beta hydrolase superfamily) [KO:K01055] [EC:3.1.1.24]
H16_B1583  catD2; 3-Oxoadipate enol-lactone hydrolase [KO:K01055] [EC:3.1.1.24]
H16_A1968  catD1; 3-Oxoadipate enol-lactone hydrolase [KO:K01055] [EC:3.1.1.24]
H16_B2288  pcaCD; 3-Oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase [KO:K14727] [EC:3.1.1.24 4.1.1.44]
H16_B0198  pcaI; 3-Oxoadipate CoA-transferase subunit A [KO:K01031] [EC:2.8.3.6]
PHG388  catI; oxoadipate CoA transferase alpha subunit [KO:K01031] [EC:2.8.3.6]
H16_B0199  pcaJ; 3-Oxoadipate CoA-transferase subunit B [KO:K01032] [EC:2.8.3.6]
PHG387  catJ; oxoadipate CoA transferase beta subunit [KO:K01032] [EC:2.8.3.6]
H16_A1290  h16_A1290; Acetyl-CoA C-acyltransferase [KO:K00632] [EC:2.3.1.16]
H16_A0462  h16_A0462; Acetyl-CoA C-acyltransferase [KO:K00632] [EC:2.3.1.16]
H16_B0200  pcaF; Beta-ketoadipyl CoA thiolase [KO:K07823] [EC:2.3.1.174]
H16_B0539  poxA; phenol hydroxylase P0 protein [KO:K16249]
H16_B0540  poxB; phenol hydroxylase P1 protein [KO:K16243] [EC:1.14.13.244 1.14.13.243]
H16_B0541  poxC; phenol hydroxylase P2 protein [KO:K16244] [EC:1.14.13.244 1.14.13.243]
H16_B0542  poxD; phenol hydroxylase P3 protein [KO:K16242] [EC:1.14.13.244 1.14.13.243]
H16_B0543  poxE; phenol hydroxylase P4 protein [KO:K16245] [EC:1.14.13.244 1.14.13.243]
H16_B0544  poxF; phenol hydroxylase P5 protein [KO:K16246] [EC:1.14.13.244 1.14.13.243]
H16_B0810  h16_B0810; amidohydrolase family protein [KO:K14333] [EC:4.1.1.46]
H16_B0546  h16_B0546; Catechol 2,3-dioxygenase [KO:K00446] [EC:1.13.11.2]
H16_B1174  h16_B1174; conserved hypothetical protein [KO:K02554] [EC:4.2.1.80]
H16_B0884  mhpD3; 2-Oxopent-4-enoate hydratase [KO:K02554] [EC:4.2.1.80]
H16_B0597  bphH; 2-Oxopent-4-enoate hydratase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
H16_B0548  mhpD1; 2-Oxopent-4-enoate hydratase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
H16_B0552  mhpE1; 4-Hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
H16_A1807  mhpE2; 4-Hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
H16_B0595  bpHI; 4-Hydroxy-2-oxovalerate aldolase [KO:K18365] [EC:4.1.3.39 4.1.3.43]
H16_B0551  mhpF; acetaldehyde dehydrogenase (acetylating) [KO:K04073] [EC:1.2.1.10]
H16_A1806  h16_A1806; acetaldehyde dehydrogenase (acetylating) [KO:K04073] [EC:1.2.1.10]
H16_B0596  h16_B0596; acetaldehyde dehydrogenase (acetylating) [KO:K18366] [EC:1.2.1.10 1.2.1.87]
H16_B0547  h16_B0547; 2-Hydroxymuconic semialdehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
H16_A3184  h16_A3184; Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [KO:K01821] [EC:5.3.2.6]
H16_B0550  h16_B0550; 4-Oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
H16_A2763  h16_A2763; Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [KO:K01821] [EC:5.3.2.6]
H16_B0549  h16_B0549; 4-Oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
H16_B0968  pcpA; 6-Chlorohydroxyquinol-1,2-dioxygenase [KO:K04098] [EC:1.13.11.37]
H16_A1786  h16_A1786; maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
H16_B0970  pcpE; 2-Chloromaleylacetate/maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
H16_B2290  pcaG; Protocatechuate 3,4-dioxygenase alpha chain [KO:K00448] [EC:1.13.11.3]
H16_B2291  pcaH1; Protocatechuate 3,4-dioxygenase beta chain [KO:K00449] [EC:1.13.11.3]
H16_A2422  pcaB2; 3-Carboxy-cis,cis-muconate cyclo-isomerase [KO:K01857] [EC:5.5.1.2]
H16_B2289  pcaB1; 3-Carboxy-cis,cis-muconate cyclo-isomerase [KO:K01857] [EC:5.5.1.2]
H16_A0535  h16_A0535; putative carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
H16_B1443  h16_B1443; Hypothetical protein [KO:K01607] [EC:4.1.1.44]
H16_B0348  menG2; demethylmenaquinone methyltransferase [KO:K10218] [EC:4.1.3.17]
H16_A1630  h16_A1630; pyridine nucleotide-disulphide oxidoreductase [KO:K00529] [EC:1.18.1.3]
H16_B0802  h16_B0802; pyridine nucleotide-disulphide oxidoreductase [KO:K00529] [EC:1.18.1.3]
H16_A1164  fdx; Ferredoxin, 2Fe-2S [KO:K04755]
H16_B2286  pobA; p-Hydroxybenzoate hydroxylase, FAD dependent monooxygenase [KO:K00481] [EC:1.14.13.2]
H16_B0876  h16_B0876; 3-Hydroxybenzoate 6-hydroxylase [KO:K22270] [EC:1.14.13.24]
H16_A2456  h16_A2456; predicted thioesterase [KO:K01075] [EC:3.1.2.23]
H16_A1412  h16_A1412; Benzoate-coenzyme A ligase [KO:K04110] [EC:6.2.1.25]
H16_B1918  h16_B1918; Benzoate-coenzyme A ligase [KO:K04110] [EC:6.2.1.25]
H16_B1693  h16_B1693; 2,3-dihydroxybenzoate-AMP ligase [KO:K04116] [EC:6.2.1.-]
H16_B1694  h16_B1694; Acyl-CoA Dehydrogenase [KO:K04117] [EC:1.3.99.-]
H16_B1696  h16_B1696; Short Chain CoA Dehydrogenase [KO:K07535] [EC:1.1.1.-]
H16_B1695  menB; naphthoate synthase [KO:K07536] [EC:3.1.2.-]
H16_B0371  pimC; Pimeloyl-CoA dehydrogenase (large subunit) [KO:K04118] [EC:1.3.1.62]
H16_B0383  h16_B0383; Acyl-CoA dehydrogenase [KO:K04118] [EC:1.3.1.62]
H16_A1526  h16_A1526; Enoyl-CoA hydratase/Delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase [KO:K07516] [EC:1.1.1.35]
H16_B0724  h16_B0724; Enoyl-CoA hydratase/isomerase family [KO:K07516] [EC:1.1.1.35]
H16_A0461  h16_A0461; two domain protein: 3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
H16_A2818  gcdH; Glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
H16_A3307  h16_A3307; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
H16_A1102  paaH2; 3-Hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
H16_A0282  paaH1; 3-Hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
H16_B1652  h16_B1652; 3-Hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
H16_A1297  h16_A1297; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1438  phaA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1445  bktB; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1528  h16_A1528; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A2148  h16_A2148; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B1369  h16_B1369; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1887  h16_A1887; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0867  h16_A0867; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0868  h16_A0868; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0872  h16_A0872; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1713  h16_A1713; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1720  h16_A1720; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A0170  h16_A0170; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0662  h16_B0662; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0668  h16_B0668; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0759  h16_B0759; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0406  h16_B0406; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0381  h16_B0381; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B0380  h16_B0380; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_B1771  h16_B1771; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
H16_A1408  bdxA; Benzoyl-CoA oxygenase component A [KO:K15511] [EC:1.14.13.208]
H16_B1912  boxA; Benzoyl-CoA dioxygenase A [KO:K15511] [EC:1.14.13.208]
H16_B1913  boxB; Benzoyl-CoA dioxygenase B [KO:K15512] [EC:1.14.13.208]
H16_A1409  bdxB; Benzoyl-CoA oxygenase component B [KO:K15512] [EC:1.14.13.208]
H16_B1917  h16_B1917; aldehyde dehydrogenase [KO:K15514] [EC:1.2.1.77]
H16_A1410  h16_A1410; Enoyl-CoA hydratase [KO:K15513] [EC:4.1.2.44]
H16_B1914  h16_B1914; Enoyl-CoA-hydratase/isomerase [KO:K15513] [EC:4.1.2.44]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C03767  4-Oxocyclohexanecarboxylate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404  trans-4-Hydroxycyclohexanecarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
C22885  cis-4-Hydroxycyclohexane-1-carboxylate
C22887  4-Oxocyclohex-2-ene-1-carboxylate
C22920  4-Oxocyclohex-2,5-dienecarboxylate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
reh00010  Glycolysis / Gluconeogenesis
reh00020  Citrate cycle (TCA cycle)
reh00350  Tyrosine metabolism
reh00360  Phenylalanine metabolism
reh00361  Chlorocyclohexane and chlorobenzene degradation
reh00627  Aminobenzoate degradation
reh00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

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