KEGG ORTHOLOGY: K18365

ORTHOLOGY: K18365

Entry

K18365                      KO

Symbol

bphI, xylK, nahM, tesG

Name

4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]

Pathway

map00362

Benzoate degradation

map00621

Dioxin degradation

map00622

Xylene degradation

map00984

Steroid degradation

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01220

Degradation of aromatic compounds

Module

M00569

Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA

Reaction

R00750

4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming)

R05298

4-hydroxy-2-oxohexanoate pyruvate-lyase (propanal-forming)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00622 Xylene degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00621 Dioxin degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
   00984 Steroid degradation
    K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Enzymes [BR:ko01000]
4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.39  4-hydroxy-2-oxovalerate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
    4.1.3.43  4-hydroxy-2-oxohexanoate aldolase
     K18365  bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase
Dioxygenases [br01602.html]
Dioxygenases in aromatic ring cleavage
  K18365

Other DBs

COG:

COG0119

GO:

0008701

Genes

PSD:

DSC_09375

LSY:	H8L67_00480(dmpG)

RGL:	CS053_01770(dmpG)

RTH:	LRK53_10290(dmpG)

RBD:	ALSL_0877 ALSL_1082

VAF:	D1115_22440(dmpG)

PATE:

NNL38_21645(dmpG)

PRE:	PCA10_13840

PFUW:

KF707C_12190 KF707C_16050(salH) KF707C_16230(bphX3)

PLAL:

FXN65_06430(dmpG)

PPI:	ND084(nahM)

PPUT:

L483_14055

PPUN:

PP4_27280(mhpE)

PVR:	PverR02_11585 PverR02_14710

PPUU:

PputUW4_01662(mhpE)

PKC:	PKB_4237(nahM)

PFZ:	AV641_10525

PALK:

PSAKL28_05980

PPSY:

AOC04_07825

PFK:	PFAS1_28765

PSET:

THL1_1435

PSIL:

PMA3_11725

PKE:	DLD99_14740(dmpG)

PUM:	HGP31_20770(dmpG)

PPSH:

G5J76_13480(dmpG)

PAZE:

KSS91_19285(dmpG)

PTAE:

NCTC10697_02055(bphI)

PCAV:

D3880_17515(dmpG)

PPHN:

HU825_04960(dmpG) HU825_14765(dmpG)

PIZ:	LAB08_R40950(dmpG)

PKM:	PZ739_11535(dmpG)

PSHS:

JJN09_05435(dmpG)

PLAU:

I0D68_06170(dmpG)

PFOU:

OZ911_14070(dmpG)

PSKP:

KU43P_19460(mhpE_1)

PDEU:

QEP73_19150(dmpG)

PBUB:

V6B39_16915(dmpG)

PSML:

V6P94_13780(dmpG)

PSMZ:

V6L79_14200(dmpG)

PALL:

UYA_06970 UYA_07050

PSC:	A458_06510

PSTU:

UIB01_22750

PBM:	CL52_14720

SDEG:

GOM96_01770(dmpG)

AVN:	Avin_30570(lapG)

AVL:	AvCA_30570(lapG)

AVD:	AvCA6_30570(lapG)

HARR:

HV822_17985(dmpG)

PPHA:

BVH74_17970

HASM:

QAO71_12440(dmpG)

MARJ:

MARI_05460(bphI)

MSHE:

MAALD49_03450(mhpE)

KAK:	Kalk_07865(dmpG)

ALC:	OTEC02_08820

AEI:	AOY20_01975

ASJ:	AsACE_CH00352(nahM)

ADV:	DJ533_16960(dmpG)

ARJ:	DOM24_01575(dmpG)

AWU:	BEN71_02690(dmpG)

ACUM:

C9E88_006015(dmpG)

ALW:	FOB21_11710(dmpG)

ATN:	FM020_13980(dmpG)

ACHI:

CDG60_02965(dmpG)

ALJ:	G8D99_13400(dmpG)

AWG:	GFH30_01715(dmpG)

ASHA:

G8E00_02255(dmpG)

ATG:	J4G44_04390(dmpG)

AVB:	RYU24_27150(mhpE)

ABOU:

ACBO_27740(mhpE_2)

ACIU:

A3K93_01265

APOT:

MZO21_10840(dmpG)

ATZ:	M5E07_14190(dmpG)

ACIE:

KIP84_08190(dmpG)

ACIG:

BS636_03595(dmpG)

ATV:	ABEF79_01860(dmpG)

SPL:

Spea_2116

SHL:

Shal_2088

SWD:

Swoo_1390

SHEM:

HWQ47_08245(dmpG)

COLW:

A3Q33_18585

CBER:

B5D82_11260(dmpG)

THT:	E2K93_11210(dmpG)

PHA:	PSHAa2143(mhpE)

PTN:	PTRA_a2596(bphI)

PNG:	PNIG_a2790(bphI)

LAL:	AT746_01290

SALH:

HMF8227_02732(bphI)

HARO:

R50071_12480(dmpG_2) R50071_15480(dmpG_3)

TTU:	TERTU_1283(dmpG)

SPOI:

IMCC21906_00395 IMCC21906_02714

SNAN:

I6N98_10790(dmpG)

STAW:

NCG89_14280(dmpG)

ZAL:	AZF00_03870 AZF00_11420 AZF00_17810

HJA:	BST95_09515

HALC:

EY643_13285(dmpG)

AFUS:

EYZ66_02685(dmpG) EYZ66_12975(dmpG)

PAQM:

E0F26_07465(dmpG)

CYQ:	Q91_0510 Q91_1491(lapG)

CZA:	CYCME_0969(lapG) CYCME_2101(dmpG)

CYY:	CPC19_05395(dmpG) CPC19_10505(dmpG)

BLEP:

AL038_01290(dmpG)

THIS:

HZT40_10615(dmpG)

AEH:

Mlg_2462

TBN:

TBH_C0930

MMW:	Mmwyl1_3801

MPRI:

MP3633_3149(mhpE)

MGEO:

CFI10_00435(dmpG) CFI10_04970(dmpG) CFI10_06050(dmpG)

MSEC:

LN244_04515(dmpG) LN244_04765(dmpG) LN244_11320(dmpG)

MRZ:	KDW95_00755(dmpG)

NCU:	F0U83_03055(dmpG)

NJP:	NEJAP_0673(mhpE)

NIK:	F5I99_02020(dmpG) F5I99_10095(dmpG) F5I99_10510(dmpG)

AJP:	AMJAP_2526 AMJAP_2997

ENW:	MJO57_21390(dmpG)

EMP:	EZMO1_1319(tesG)

ASIM:

FE240_03470(dmpG)

ZDF:	AN401_14615

SOK:	D0B54_06190(dmpG)

SINI:

GT972_14660(dmpG)

FCE:	JN531_005840(dmpG)

GBI:	PG2T_09675

GPB:	HDN1F_27070(tesG)

NZO:	SAMEA4504057_0444(bphI)

NCI:	NCTC10296_00917(bphI)

NWD:	H3L96_04775(dmpG)

NDU:	LVJ88_00580(dmpG)

VFF:	VITFI_CDS1376

PTES:

JQU52_04850(dmpG)

USU:	LVJ78_03650(dmpG)

AQL:	BXU06_16260 BXU06_16885 BXU06_17065

RPI:

Rpic_4617

RPF:	Rpic12D_3541

RIN:	ACS15_4356

REH:	H16_B0595(bpHI)

CNC:	CNE_2c05400(bpHI)

CUH:	BJN34_24650

RME:	Rmet_1319(bphI)

CTI:	RALTA_B0399(mhpE)

CBW:	RR42_s2315

COX:	E0W60_08015(dmpG)

CCAX:

KZ686_10005(dmpG)

CUK:	KB879_20415(dmpG)

CUPP:

CTP10_R38450(dmpG)

BVI:	Bcep1808_7605

BUR:	Bcep18194_B1457 Bcep18194_B2959

BCJ:	BCAM1615(bphI)

BCEN:

DM39_3381(dmpG) DM39_4832(dmpG)

BCEO:

I35_5475(bphI)

BCT:	GEM_4109 GEM_5401

BCED:

DM42_4991(dmpG) DM42_6343(dmpG)

BCEP:

APZ15_31145

BPYR:

ABD05_27810

BCON:

NL30_04130 NL30_24590

BDF:	WI26_15995 WI26_21155

BTEI:

WS51_00570 WS51_05705

BPSL:

WS57_06035 WS57_12155

BMEC:

WJ16_26800

BSTL:

BBJ41_10520 BBJ41_21350

BANN:

JFN94_19135(dmpG) JFN94_25660(dmpG)

BARI:

NLX30_30175(dmpG)

BAEN:

L3V59_21750(dmpG) L3V59_30405(dmpG)

BUQ:	AC233_11185

BURK:

DM992_32615(dmpG)

BXE:	Bxe_C1187(bphI)

BXB:	DR64_8618(dmpG)

BFN:	OI25_4591(dmpG)

PARB:

CJU94_37880(dmpG) CJU94_38125(dmpG)

PCAF:

DSC91_003289

PMEG:

FNZ07_21155(dmpG)

PBRY:

NDK50_32885(dmpG)

PPAI:

E1956_37230(dmpG)

PHUN:

U0042_26780(dmpG)

PPK:	U875_01890

PRB:	X636_07580

CABA:

SBC2_49000(bphI)

LIMN:

HKT17_03830(dmpG)

AXY:	AXYL_04307(dmpG)

APES:

FOC84_00305(dmpG)

AALN:

Q3V95_01645(dmpG)

CDN:	BN940_14431

RFR:

Rfer_0454

RLH:	MIZ03_0650 MIZ03_1026

PNA:

AJS:

ACID:

ACIP:

ACIN:

ACIS:

AMON:

H9L24_14175(dmpG)

VEI:

Veis_2781

VBO:	CKY39_28495(dmpG)

VAV:	IG196_08140(dmpG)

VAE:	RZE79_18240(dmpG)

CTT:	CtCNB1_1351 CtCNB1_3147

CTES:

O987_07730

COF:	FOZ74_08315(dmpG)

CRJ:	QMY55_07010(dmpG)

ADN:	Alide_0339

ADK:	Alide2_0284

OTD:	J1M35_00045(dmpG)

HYL:	LPB072_18200

HPSE:

HPF_01850(bphI)

HYN:	F9K07_02775(dmpG) F9K07_11450(dmpG) F9K07_31030(dmpG)

HTN:	KI616_01945(dmpG)

DIH:	G7047_09695(dmpG)

DIM:	K2L43_01285(dmpG)

SIMP:

C6571_13625(dmpG)

MELA:

C6568_07850(dmpG)

MJE:	LVC68_01015(dmpG)

STHM:

IS481_10550(dmpG)

SAQA:

OMP39_09130(dmpG)

MPT:	Mpe_A2266 Mpe_A3321

METP:

C1M51_06440(dmpG) C1M51_16320(dmpG)

SNN:	EWH46_19310(dmpG)

SMIO:

CATMQ487_04050(mhpE_1) CATMQ487_17590(mhpE_2) CATMQ487_31630(mhpE_3)

IDC:	LRM40_19585(dmpG)

LCH:

Lcho_3340

JAJ:	EKL02_01800(dmpG) EKL02_13150(dmpG)

MASW:

AM586_18660

TMJ:	P0M04_30655(dmpG)

RBU:	PG1C_14090

ABRE:

pbN1_20580(mhpE)

DAR:	Daro_0907 Daro_1356 Daro_3782 Daro_3808

DEY:	HYN24_14110(dmpG) HYN24_14200(dmpG)

DDEN:

KI615_16870(dmpG)

QAU:	KI612_15145(dmpG)

FLE:	KI610_08595(dmpG) KI610_13435(dmpG) KI610_15450(dmpG)

AZO:	azo1857(lapG) azo1972(mhpE) azo2431(nahM)

AOA:	dqs_2010 dqs_2127 dqs_2575

AZI:	AzCIB_1509 AzCIB_4409

AZD:	CDA09_09965(dmpG) CDA09_10335(dmpG) CDA09_10460(dmpG) CDA09_21430(dmpG)

AZR:	CJ010_12270(dmpG) CJ010_12835(dmpG) CJ010_15205(dmpG)

TMZ:	Tmz1t_2079 Tmz1t_3105

THU:	AC731_001820 AC731_008905

THAU:

C4PIVTH_2809(mhpE) C4PIVTH_4319(mhpE) C4PIVTH_4382(mhpE)

THK:	CCZ27_04605(dmpG) CCZ27_10750(dmpG)

THAG:

CKCBHOJB_01548(bphI_1) CKCBHOJB_02381(bphI_2)

AZQ:	G3580_00550(dmpG) G3580_08280(dmpG)

ACOM:

CEW83_03610(dmpG)

NPM:	QEO92_31660(dmpG)

SHZ:

shn_33310

CID:

P73_1382

DAA:	AKL17_3p0139

TEC:	AKL02_008270(dmpG)

PGV:	SL003B_p0059

NPP:	PP1Y_AT32722

SGI:	SGRAN_1579(mhpE)

SJP:	SJA_C1-11910(mhpE_xylK)

SINB:

SIDU_08310

SYB:	TZ53_09030 TZ53_23475

SHYD:

CJD35_06515(dmpG)

SBAR:

H5V43_20635(dmpG)

SFLA:

SPHFLASMR4Y_02366(bphI)

SPHJ:

BSL82_10435

ALTN:

LBX01_06750(dmpG)

PMAS:

NCF86_10605(dmpG)

TFV:	IDJ81_04960(dmpG)

TXI:

TH3_21418

HTL:

HPTL_0047

ACIB:

ACBT_0259(dmpG)

AFC:	AFAEC_1844(dmpG)

AAQI:

AAQM_0982(dmpG)

ACLO:

ACLO_a0139(dmpG)

ADZ:	ADFLV_2551(dmpG)

ARC:

ABLL_2442

AROS:

NJU99_01650(dmpG)

ALK:	ALEK_0383(dmpG)

AANA:

AANAER_1260(dmpG)

SSM:	Spirs_4175

GYC:	GYMC61_2298

GYA:	GYMC52_1426

GCT:	GC56T3_2055

GGH:	GHH_c14840(pheE)

GJF:	M493_17920

AAD:	TC41_0802(mhpE)

AACO:

K1I37_06160(dmpG)

ADAU:

NZD86_00705(dmpG) NZD86_06135(dmpG)

AFAS:

NZD89_10110(dmpG)

ALIC:

GI364_17540(dmpG)

BTS:

Btus_0969

KYR:	CVV65_10345(dmpG) CVV65_11290(dmpG)

DHD:

Dhaf_1245

DCA:	Desca_1927

LACY:

MTHO:

MTHZ:

TOC:

STED:

SPTER_03000 SPTER_36960(bphI)

SSPH:

SPSPH_044540(mhpE)

» show all

Reference

PMID:16151114

Authors

Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T

Title

Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.

Journal

Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005

Sequence

[ctt:CtCNB1_1351]

LinkDB

DBGET integrated database retrieval system