KEGG   PATHWAY: rhj00260
Entry
rhj00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Rhodoblastus sp. SSC7
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
rhj00260  Glycine, serine and threonine metabolism
rhj00260

Module
rhj_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:rhj00260]
rhj_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:rhj00260]
rhj_M00621  Glycine cleavage system [PATH:rhj00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Rhodoblastus sp. SSC7 [GN:rhj]
Gene
HZY79_07360  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HZY79_04595  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HZY79_11255  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
HZY79_01880  homoserine kinase [KO:K02204] [EC:2.7.1.39]
HZY79_01140  threonine synthase [KO:K01733] [EC:4.2.3.1]
HZY79_07665  low specificity L-threonine aldolase [KO:K01620] [EC:4.1.2.48]
HZY79_14490  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HZY79_03130  glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
HZY79_07195  glycerate kinase [KO:K11529] [EC:2.7.1.165]
HZY79_01945  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HZY79_07885  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HZY79_07890  phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
HZY79_10570  serB; phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
HZY79_05475  hemA; 5-aminolevulinate synthase [KO:K00643] [EC:2.3.1.37]
HZY79_11155  FAD-dependent oxidoreductase [KO:K00274] [EC:1.4.3.4]
HZY79_01630  gcvPA; aminomethyl-transferring glycine dehydrogenase subunit GcvPA [KO:K00282] [EC:1.4.4.2]
HZY79_01635  gcvPB; aminomethyl-transferring glycine dehydrogenase subunit GcvPB [KO:K00283] [EC:1.4.4.2]
HZY79_01620  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HZY79_00840  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HZY79_06450  dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HZY79_11915  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HZY79_05340  sarcosine oxidase subunit alpha family protein [KO:K00302] [EC:1.5.3.24 1.5.3.1]
HZY79_05350  sarcosine oxidase subunit beta family protein [KO:K00303] [EC:1.5.3.24 1.5.3.1]
HZY79_05335  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
HZY79_05345  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
HZY79_09530  threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
HZY79_10735  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
HZY79_02430  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HZY79_03545  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
HZY79_03220  TrpB-like pyridoxal phosphate-dependent enzyme [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
rhj00010  Glycolysis / Gluconeogenesis
rhj00020  Citrate cycle (TCA cycle)
rhj00230  Purine metabolism
rhj00250  Alanine, aspartate and glutamate metabolism
rhj00270  Cysteine and methionine metabolism
rhj00290  Valine, leucine and isoleucine biosynthesis
rhj00300  Lysine biosynthesis
rhj00330  Arginine and proline metabolism
rhj00460  Cyanoamino acid metabolism
rhj00470  D-Amino acid metabolism
rhj00564  Glycerophospholipid metabolism
rhj00620  Pyruvate metabolism
rhj00630  Glyoxylate and dicarboxylate metabolism
rhj00640  Propanoate metabolism
rhj00680  Methane metabolism
rhj00860  Porphyrin metabolism
rhj00920  Sulfur metabolism
KO pathway
ko00260   
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