KEGG   PATHWAY: rpj00362
Entry
rpj00362                    Pathway                                
Name
Benzoate degradation - Ralstonia pickettii DTP0602
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
rpj00362  Benzoate degradation
rpj00362

Module
rpj_M00548  Benzene degradation, benzene => catechol [PATH:rpj00362]
rpj_M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:rpj00362]
rpj_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:rpj00362]
rpj_M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:rpj00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Ralstonia pickettii DTP0602 [GN:rpj]
Gene
N234_37285  benzoate 1,2-dioxygenase subunit alpha [KO:K05549] [EC:1.14.12.10 1.14.12.-]
N234_37280  benzoate 1,2-dioxygenase subunit beta [KO:K05550] [EC:1.14.12.10 1.14.12.-]
N234_34770  methane monooxygenase [KO:K05784] [EC:1.18.1.-]
N234_37275  NADH oxidase [KO:K05784] [EC:1.18.1.-]
N234_37270  benD; 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
N234_27840  hypothetical protein [KO:K05783] [EC:1.3.1.25 1.3.1.-]
N234_37290  catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
N234_27855  muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
N234_27860  muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
N234_00525  3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
N234_27870  3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
N234_15830  alpha/beta hydrolase [KO:K01055] [EC:3.1.1.24]
N234_32957  AraC family transcriptional regulator [KO:K14727] [EC:3.1.1.24 4.1.1.44]
N234_21855  3-oxoadipate CoA-transferase subunit A [KO:K01031] [EC:2.8.3.6]
N234_37600  3-oxoadipate CoA-transferase subunit A [KO:K01031] [EC:2.8.3.6]
N234_21860  3-oxoadipate CoA-transferase subunit B [KO:K01032] [EC:2.8.3.6]
N234_37605  3-oxoadipate CoA-transferase subunit B [KO:K01032] [EC:2.8.3.6]
N234_10955  acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
N234_02240  acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
N234_21865  acetyl-CoA acetyltransferase [KO:K07823] [EC:2.3.1.174]
N234_08105  phenol hydroxylase [KO:K16249]
N234_08110  phenol hydroxylase [KO:K16243] [EC:1.14.13.244 1.14.13.243]
N234_08115  monooxygenase [KO:K16244] [EC:1.14.13.244 1.14.13.243]
N234_08120  phenol 2-monooxygenase [KO:K16242] [EC:1.14.13.244 1.14.13.243]
N234_08125  phenol hydroxylase [KO:K16245] [EC:1.14.13.244 1.14.13.243]
N234_08130  phenol hydroxylase [KO:K16246] [EC:1.14.13.244 1.14.13.243]
N234_24875  amidohydrolase [KO:K14333] [EC:4.1.1.46]
N234_08140  catechol 2,3 dioxygenase [KO:K00446] [EC:1.13.11.2]
N234_12230  bleomycin resistance protein [KO:K10621] [EC:1.13.11.- 1.13.11.14]
N234_12225  aldolase [KO:K10622] [EC:4.1.1.-]
N234_29175  2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
N234_34805  2-keto-4-pentenoate hydratase [KO:K02554] [EC:4.2.1.80]
N234_23035  2-oxo-hept-3-ene-1,7-dioate hydratase [KO:K02554] [EC:4.2.1.80]
N234_12215  2-keto-4-pentenoate hydratase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
N234_08150  2-keto-4-pentenoate hydratase [KO:K18364] [EC:4.2.1.80 4.2.1.132]
N234_12195  4-hyroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
N234_08170  4-hyroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
N234_23020  4-hyroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
N234_29155  4-hyroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
N234_34815  4-hyroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
N234_12200  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
N234_08165  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
N234_23025  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
N234_29160  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
N234_34810  acetaldehyde dehydrogenase [KO:K04073] [EC:1.2.1.10]
N234_08145  gabD; succinate-semialdehyde dehdyrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
N234_12220  aldehyde dehydrogenase [KO:K10217] [EC:1.2.1.32 1.2.1.85]
N234_12205  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
N234_08160  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
N234_18065  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
N234_23240  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
N234_09400  hypothetical protein [KO:K01821] [EC:5.3.2.6]
N234_15590  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
N234_12210  4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
N234_08155  4-oxalocrotonate decarboxylase [KO:K01617] [EC:4.1.1.77]
N234_22425  6-chlorohydroxyquinol-1,2-dioxygenase [KO:K04098] [EC:1.13.11.37]
N234_22775  catechol 1,2-dioxygenase [KO:K04098] [EC:1.13.11.37]
N234_23165  Maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
N234_22320  alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
N234_25035  hypothetical protein [KO:K00217] [EC:1.3.1.32]
N234_10865  alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
N234_32975  protocatechuate 3,4-dioxygenase subunit alpha [KO:K00448] [EC:1.13.11.3]
N234_32980  protocatechuate 3,4-dioxygenase subunit beta [KO:K00449] [EC:1.13.11.3]
N234_22615  3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
N234_09430  3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
N234_32970  3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
N234_02595  4-carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
N234_29205  hypothetical protein [KO:K04101] [EC:1.13.11.8]
N234_28990  diguanylate cyclase [KO:K10218] [EC:4.1.3.17]
N234_29380  diguanylate cyclase [KO:K10218] [EC:4.1.3.17]
N234_26325  diguanylate cyclase [KO:K10218] [EC:4.1.3.17]
N234_29045  diguanylate cyclase [KO:K10218] [EC:4.1.3.17]
N234_29335  diguanylate cyclase [KO:K10218] [EC:4.1.3.17]
N234_12820  hypothetical protein [KO:K00529] [EC:1.18.1.3]
N234_24835  ferredoxin reductase [KO:K00529] [EC:1.18.1.3]
N234_12825  hypothetical protein [KO:K04755]
N234_05490  (2Fe-2S) ferredoxin [KO:K04755]
N234_21540  4-hydroxybenzoate 3-monooxygenase [KO:K00481] [EC:1.14.13.2]
N234_25225  hypothetical protein [KO:K22270] [EC:1.14.13.24]
N234_25345  salicylate hydroxylase [KO:K22270] [EC:1.14.13.24]
N234_03105  4-hydroxybenzoyl-CoA thioesterase [KO:K01075] [EC:3.1.2.23]
N234_14065  4-hydroxybenzoyl-CoA thioesterase [KO:K01075] [EC:3.1.2.23]
N234_23135  thioesterase [KO:K01075] [EC:3.1.2.23]
N234_07060  4-hydroxybenzoate--CoA ligase [KO:K04110] [EC:6.2.1.25]
N234_31305  2-aminobenzoate-CoA ligase [KO:K04110] [EC:6.2.1.25]
N234_30130  cyclohexanecarboxylate-CoA ligase [KO:K04116] [EC:6.2.1.-]
N234_30135  butyryl-CoA dehydrogenase [KO:K04117] [EC:1.3.99.-]
N234_30145  acetoacetyl-CoA reductase [KO:K07535] [EC:1.1.1.-]
N234_06000  hypothetical protein [KO:K07535] [EC:1.1.1.-]
N234_09165  hypothetical protein [KO:K07535] [EC:1.1.1.-]
N234_30140  dihydroxynaphthoic acid synthetase [KO:K07536] [EC:3.1.2.-]
N234_06005  dihydroxynaphthoic acid synthetase [KO:K07536] [EC:3.1.2.-]
N234_35745  3-hydroxyacyl-CoA dehydrogenase [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
N234_07610  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
N234_02235  3-hydroxyacyl-CoA dehydrogenase [KO:K07516] [EC:1.1.1.35]
N234_15875  isovaleryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
N234_18640  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
N234_05185  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_09625  hypothetical protein [KO:K00074] [EC:1.1.1.157]
N234_09630  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_09690  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_01275  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_06065  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_06070  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_29890  3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
N234_07620  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_35750  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_23455  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
N234_27995  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_37220  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_24635  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_00640  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_09290  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_23490  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_36935  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
N234_06460  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_07185  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
N234_07210  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
N234_31275  benzoyl-CoA oxygenase [KO:K15511] [EC:1.14.13.208]
N234_07040  benzoyl-CoA oxygenase [KO:K15511] [EC:1.14.13.208]
N234_31280  benzoyl-CoA oxygenase [KO:K15512] [EC:1.14.13.208]
N234_07045  benzoyl-CoA oxygenase [KO:K15512] [EC:1.14.13.208]
N234_31300  aldehyde dehydrogenase [KO:K15514] [EC:1.2.1.77]
N234_31285  crotonase [KO:K15513] [EC:4.1.2.44]
N234_07050  crotonase [KO:K15513] [EC:4.1.2.44]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C03767  4-Oxocyclohexanecarboxylate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404  trans-4-Hydroxycyclohexanecarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
C22885  cis-4-Hydroxycyclohexane-1-carboxylate
C22887  4-Oxocyclohex-2-ene-1-carboxylate
C22920  4-Oxocyclohex-2,5-dienecarboxylate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
rpj00010  Glycolysis / Gluconeogenesis
rpj00020  Citrate cycle (TCA cycle)
rpj00350  Tyrosine metabolism
rpj00360  Phenylalanine metabolism
rpj00361  Chlorocyclohexane and chlorobenzene degradation
rpj00627  Aminobenzoate degradation
rpj00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

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