PATHWAY: salp00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Salvelinus sp. IW2-2015 (Arctic char)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:
salp ]
Gene
112077144 idh3a; LOW QUALITY PROTEIN: isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial [KO:K00030 ] [EC:1.1.1.41 ]
111962559 LOW QUALITY PROTEIN: isocitrate dehydrogenase [NAD] subunit beta, mitochondrial-like [KO:K00030 ] [EC:1.1.1.41 ]
112074912 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
112069409 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
111963268 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658 ] [EC:2.3.1.61 ]
111968739 dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
112068963 LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
111954921 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
111979797 sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236 ]
111975097 succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236 ]
111960034 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial isoform X1 [KO:K00237 ]
111949365 succinate dehydrogenase [ubiquinone] cytochrome b small subunit B, mitochondrial [KO:K00237 ]
111950366 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
112072134 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161 ] [EC:1.2.4.1 ]
111973256 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
111964305 pyruvate dehydrogenase E1 component subunit alpha, mitochondrial isoform X1 [KO:K00161 ] [EC:1.2.4.1 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
salp00250 Alanine, aspartate and glutamate metabolism
salp00280 Valine, leucine and isoleucine degradation
salp00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs