KEGG   PATHWAY: salu00280
Entry
salu00280                   Pathway                                
Name
Valine, leucine and isoleucine degradation - Streptomyces noursei NK660
Class
Metabolism; Amino acid metabolism
Pathway map
salu00280  Valine, leucine and isoleucine degradation
salu00280

Module
salu_M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA [PATH:salu00280]
salu_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:salu00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces noursei NK660 [GN:salu]
Gene
DC74_7622  branched-chain-amino-acid transaminase [KO:K00826] [EC:2.6.1.42]
DC74_2000  D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]
DC74_5655  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
DC74_4008  valine dehydrogenase (NADP+) [KO:K00271] [EC:1.4.1.23]
DC74_4158  3-methyl-2-oxobutanoate dehydrogenase (lipoamide) E1-alpha chain [KO:K00166] [EC:1.2.4.4]
DC74_4144  putative branched-chain alpha keto acid dehydrogenase E1 alpha subunit [KO:K00166] [EC:1.2.4.4]
DC74_4143  E1-beta branched-chain alpha-keto-acid dehydrogenase system [KO:K00167] [EC:1.2.4.4]
DC74_4157  putative branched-chain alpha keto acid dehydrogenase E1 beta subunit [KO:K00167] [EC:1.2.4.4]
DC74_4142  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K09699] [EC:2.3.1.168]
DC74_4156  branched-chain alpha-keto acid dehydrogenase subunit E2 [KO:K09699] [EC:2.3.1.168]
DC74_896  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
DC74_2672  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
DC74_2173  acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
DC74_7879  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
DC74_5985  acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
DC74_7476  acyl-CoA dehydrogenase domain-containing protein [KO:K00249] [EC:1.3.8.7]
DC74_7674  acyl-CoA dehydrogenase domain-containing protein [KO:K00249] [EC:1.3.8.7]
DC74_3256  acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.8.5]
DC74_5990  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
DC74_7676  enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
DC74_5577  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
DC74_6742  fatty acid oxidation complex alpha-subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
DC74_6063  3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
DC74_2789  lipid-transfer protein [KO:K00632] [EC:2.3.1.16]
DC74_5105  acyl-CoA carboxylase subunit alpha [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
DC74_5114  propionyl-CoA carboxylase complex subunit beta [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
DC74_5113  hypothetical protein [KO:K27095]
DC74_5532  hypothetical protein [KO:K05606] [EC:5.1.99.1]
DC74_6708  methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
DC74_5052  methylmalonyll-CoA mutase [KO:K01848] [EC:5.4.99.2]
DC74_2881  dehydrogenase [KO:K00020] [EC:1.1.1.31]
DC74_420  3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
DC74_5989  3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
DC74_5986  methylmalonic acid semialdehyde dehydrogenase MmsA [KO:K00140] [EC:1.2.1.18 1.2.1.27]
DC74_3210  methylmalonic acid semialdehyde dehydrogenase [KO:K00140] [EC:1.2.1.18 1.2.1.27]
DC74_5090  hypothetical protein [KO:K00128] [EC:1.2.1.3]
DC74_4549  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
DC74_2194  hypothetical protein [KO:K00128] [EC:1.2.1.3]
DC74_2802  oxidoreductase [KO:K00128] [EC:1.2.1.3]
DC74_1642  acyl-CoA synthetase [KO:K18661] [EC:6.2.1.76 6.2.1.-]
DC74_7028  beta alanine--pyruvate transaminase [KO:K00822] [EC:2.6.1.18]
DC74_5775  4-aminobutyrate aminotransferase [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
DC74_3254  acetyl/propionyl CoA carboxylase subunit alpha [KO:K01968] [EC:6.4.1.4]
DC74_3253  acetyl/propionyl CoA carboxylase, beta subunit [KO:K01969] [EC:6.4.1.4]
DC74_7170  3-hydroxybutyryl-CoA dehydratase [KO:K13766] [EC:4.2.1.18]
DC74_3255  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
DC74_485  3-oxoacid CoA-transferase subunit A [KO:K01028] [EC:2.8.3.5]
DC74_484  3-oxoacid CoA-transferase subunit B [KO:K01029] [EC:2.8.3.5]
DC74_1680  acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
DC74_6741  thiolase/acety-coA transferase [KO:K00626] [EC:2.3.1.9]
DC74_2809  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DC74_1722  keto acyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
DC74_5533  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DC74_7430  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DC74_3526  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
salu00020  Citrate cycle (TCA cycle)
salu00240  Pyrimidine metabolism
salu00290  Valine, leucine and isoleucine biosynthesis
salu00640  Propanoate metabolism
salu00900  Terpenoid backbone biosynthesis
salu01056  Biosynthesis of type II polyketide backbone
KO pathway
ko00280   
LinkDB

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