KEGG   PATHWAY: sge00630
Entry
sge00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Streptomyces griseorubiginosus
Class
Metabolism; Carbohydrate metabolism
Pathway map
sge00630  Glyoxylate and dicarboxylate metabolism
sge00630

Module
sge_M00621  Glycine cleavage system [PATH:sge00630]
sge_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:sge00630]
Other DBs
GO: 0046487 0043648
Organism
Streptomyces griseorubiginosus [GN:sge]
Gene
DWG14_03850  acsA_3; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
DWG14_01842  acsA_2; Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
DWG14_01807  aceB; Malate synthase [KO:K01638] [EC:2.3.3.9]
DWG14_00486  ldhA; L-lactate dehydrogenase 1 [KO:K00024] [EC:1.1.1.37]
DWG14_03312  mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
DWG14_05384  gltA2; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
DWG14_04737  citA_3; Putative citrate synthase 2 [KO:K01647] [EC:2.3.3.1]
DWG14_02203  citA_1; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
DWG14_02204  citA_2; Citrate synthase 1 [KO:K01647] [EC:2.3.3.1]
DWG14_02118  acnA; Aconitate hydratase A [KO:K27802] [EC:4.2.1.3 4.2.1.99]
DWG14_07811  hypothetical protein [KO:K00626] [EC:2.3.1.9]
DWG14_08127  fadA5_2; Steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
DWG14_01434  fadA_1; Putative acyltransferase [KO:K00626] [EC:2.3.1.9]
DWG14_05956  fadA5_1; Steroid 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
DWG14_02747  putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DWG14_03593  fadI_1; 3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
DWG14_00469  putative acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DWG14_04988  thlA; Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
DWG14_02748  cetB; 2-epi-5-epi-valiolone epimerase [KO:K05606] [EC:5.1.99.1]
DWG14_01739  scpA_1; Methylmalonyl-CoA mutase [KO:K14447] [EC:5.4.99.63]
DWG14_08027  accD5_2; putative propionyl-CoA carboxylase beta chain 5 [KO:K01966] [EC:6.4.1.3 2.1.3.15]
DWG14_03180  accC; Biotin carboxylase [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.4.1.- 6.3.4.14]
DWG14_03175  accD5_1; putative propionyl-CoA carboxylase beta chain 5 [KO:K27094] [EC:6.4.1.3 6.4.1.- 2.1.3.15]
DWG14_03176  hypothetical protein [KO:K27095]
DWG14_01868  mutA; putative methylmalonyl-CoA mutase small subunit [KO:K01847] [EC:5.4.99.2]
DWG14_01869  mutB_1; Methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
DWG14_03235  scpA_2; Methylmalonyl-CoA mutase [KO:K01848] [EC:5.4.99.2]
DWG14_05189  putative FAD-linked oxidoreductase [KO:K00104] [EC:1.1.99.14]
DWG14_01693  katE; Catalase HPII [KO:K03781] [EC:1.11.1.6]
DWG14_08077  katA; Catalase [KO:K03781] [EC:1.11.1.6]
DWG14_04691  gph_3; Phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
DWG14_00349  glnA_1; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DWG14_01362  glnA_2; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DWG14_06870  ipuC; Glutamate--isopropylamine ligase [KO:K01915] [EC:6.3.1.2]
DWG14_06077  glnA_3; Glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
DWG14_06109  glnII; Glutamine synthetase 2 [KO:K01915] [EC:6.3.1.2]
DWG14_06127  glnA_4; Glutamine synthetase [KO:K01915] [EC:6.3.1.2]
DWG14_01372  glyA2_1; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DWG14_02607  glyA2_2; Serine hydroxymethyltransferase 2 [KO:K00600] [EC:2.1.2.1]
DWG14_03289  glyA_2; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DWG14_02778  glyA_1; Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
DWG14_07122  gcvP; putative glycine dehydrogenase (decarboxylating) [KO:K00281] [EC:1.4.4.2]
DWG14_02605  gcvT_2; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
DWG14_00332  gcvT_1; Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
DWG14_06149  pdhD; Dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
DWG14_02606  gcvH; Glycine cleavage system H protein [KO:K02437]
DWG14_01839  gcl; Glyoxylate carboligase [KO:K01608] [EC:4.1.1.47]
DWG14_01837  hyi; Hydroxypyruvate isomerase [KO:K01816] [EC:5.3.1.22]
DWG14_01838  garR_2; 2-hydroxy-3-oxopropionate reductase [KO:K00042] [EC:1.1.1.60]
DWG14_01751  glxK; Glycerate 3-kinase [KO:K00865] [EC:2.7.1.165]
DWG14_00515  dmlA; D-malate dehydrogenase [decarboxylating] [KO:K07246] [EC:1.1.1.93 4.1.1.73 1.1.1.83]
DWG14_08166  eda_3; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
DWG14_06000  eda_1; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
DWG14_07242  eda_2; KHG/KDPG aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
DWG14_02860  kgd; Multifunctional 2-oxoglutarate metabolism enzyme [KO:K01616] [EC:2.2.1.5 4.1.1.71 1.2.4.2 2.3.1.61]
DWG14_01608  hypothetical protein [KO:K00126] [EC:1.17.1.9]
DWG14_01609  Putative formate dehydrogenase [KO:K00123] [EC:1.17.1.9]
DWG14_01610  hndC; NADP-reducing hydrogenase subunit HndC [KO:K00124]
DWG14_01611  hndA; NADP-reducing hydrogenase subunit HndA [KO:K00127]
DWG14_08381  fdoI; Formate dehydrogenase, cytochrome b556(fdo) subunit [KO:K00127]
DWG14_06779  fdnI; Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit [KO:K00127]
DWG14_08251  aes_2; Acetyl esterase [KO:K01432] [EC:3.5.1.9]
DWG14_00333  purU_1; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
DWG14_04751  purU_2; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
DWG14_07338  purU_3; Formyltetrahydrofolate deformylase [KO:K01433] [EC:3.5.1.10]
DWG14_01605  oxc; Oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
DWG14_01618  frc_3; Formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
DWG14_01604  frc_1; Formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
DWG14_01614  frc_2; Formyl-CoA:oxalate CoA-transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
sge00010  Glycolysis / Gluconeogenesis
sge00020  Citrate cycle (TCA cycle)
sge00030  Pentose phosphate pathway
sge00053  Ascorbate and aldarate metabolism
sge00071  Fatty acid degradation
sge00230  Purine metabolism
sge00250  Alanine, aspartate and glutamate metabolism
sge00260  Glycine, serine and threonine metabolism
sge00620  Pyruvate metabolism
sge00710  Carbon fixation by Calvin cycle
sge00750  Vitamin B6 metabolism
sge00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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