KEGG   PATHWAY: sita00480
Entry
sita00480                   Pathway                                
Name
Glutathione metabolism - Setaria italica (foxtail millet)
Class
Metabolism; Metabolism of other amino acids
Pathway map
sita00480  Glutathione metabolism
sita00480

Module
sita_M00118  Glutathione biosynthesis, glutamate => glutathione [PATH:sita00480]
Other DBs
GO: 0006749
Organism
Setaria italica (foxtail millet) [GN:sita]
Gene
101785132  glutathione hydrolase 3 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101768460  glutathione hydrolase 1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
101768570  gamma-glutamylcyclotransferase 2-2 [KO:K22596] [EC:4.3.2.9]
101779265  gamma-glutamylcyclotransferase 2-3 [KO:K22596] [EC:4.3.2.9]
105915176  LOW QUALITY PROTEIN: 5-oxoprolinase [KO:K01469] [EC:3.5.2.9]
101765990  glutamate--cysteine ligase B, chloroplastic [KO:K01919] [EC:6.3.2.2]
101753211  glutamate--cysteine ligase A, chloroplastic [KO:K01919] [EC:6.3.2.2]
101778090  glutathione synthetase, chloroplastic [KO:K21456] [EC:6.3.2.3]
101780781  glutathione synthetase, chloroplastic isoform X1 [KO:K21456] [EC:6.3.2.3]
101768704  leucine aminopeptidase 2, chloroplastic [KO:K01255] [EC:3.4.11.1]
101757755  puromycin-sensitive aminopeptidase [KO:K01256] [EC:3.4.11.2]
101758653  uncharacterized protein LOC101758653 [KO:K00799] [EC:2.5.1.18]
101763376  uncharacterized protein LOC101763376 [KO:K00799] [EC:2.5.1.18]
105914892  uncharacterized protein LOC105914892 [KO:K00799] [EC:2.5.1.18]
101781774  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
101759727  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
101756971  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101760080  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
101767617  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101779885  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101776513  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101776918  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101771251  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101773133  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101775016  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101775422  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101776115  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101776517  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101776923  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101778030  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101760610  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101761158  glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101761945  probable glutathione S-transferase parC [KO:K00799] [EC:2.5.1.18]
101782651  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
101783067  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
101783467  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
101783868  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
101758588  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
101758250  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101777261  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101764756  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
101767217  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
101767877  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
101772003  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
101772403  probable glutathione S-transferase GSTU1 [KO:K00799] [EC:2.5.1.18]
101764309  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101764715  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
101761238  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
101782260  glutathione S-transferase T1 [KO:K00799] [EC:2.5.1.18]
101785634  glutathione S-transferase U24 [KO:K00799] [EC:2.5.1.18]
101766913  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
101759060  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101759463  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
101773452  glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
101759868  uncharacterized protein LOC101759868 [KO:K00799] [EC:2.5.1.18]
101760689  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101761093  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101761477  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101762159  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101764179  uncharacterized protein LOC101764179 [KO:K00799] [EC:2.5.1.18]
101765264  probable glutathione S-transferase GSTU6 isoform X1 [KO:K00799] [EC:2.5.1.18]
101765948  glutathione S-transferase U17 [KO:K00799] [EC:2.5.1.18]
101783765  protein IN2-1 homolog B isoform X1 [KO:K00799] [EC:2.5.1.18]
101784448  protein IN2-1 [KO:K00799] [EC:2.5.1.18]
101765813  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
101766234  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
101766640  glutathione S-transferase F8, chloroplastic [KO:K00799] [EC:2.5.1.18]
101767054  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
101767763  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101777608  probable glutathione S-transferase [KO:K00799] [EC:2.5.1.18]
101763133  glutathione S-transferase 4 [KO:K00799] [EC:2.5.1.18]
101762564  uncharacterized protein LOC101762564 [KO:K00799] [EC:2.5.1.18]
111255738  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101757829  probable glutathione S-transferase GSTU6 [KO:K00799] [EC:2.5.1.18]
101767471  glutathione S-transferase F11 [KO:K00799] [EC:2.5.1.18]
101761980  LOW QUALITY PROTEIN: glutathione transferase GST 23 [KO:K00799] [EC:2.5.1.18]
111257325  probable glutathione S-transferase GSTF1 [KO:K00799] [EC:2.5.1.18]
101786893  probable glutathione S-transferase BZ2 [KO:K00799] [EC:2.5.1.18]
101766925  glutathione S-transferase U10 [KO:K00799] [EC:2.5.1.18]
101755175  uncharacterized protein LOC101755175 isoform X1 [KO:K00799] [EC:2.5.1.18]
101759688  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101769608  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
101759106  glutathione reductase, cytosolic [KO:K00383] [EC:1.8.1.7]
101762040  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
101783787  glutathione reductase, chloroplastic [KO:K00383] [EC:1.8.1.7]
101783737  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
101772045  cytosolic isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
101764125  isocitrate dehydrogenase [NADP] [KO:K00031] [EC:1.1.1.42]
101779232  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
101785640  6-phosphogluconate dehydrogenase, decarboxylating 1 [KO:K00033] [EC:1.1.1.44 1.1.1.343]
101779163  6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic [KO:K00033] [EC:1.1.1.44 1.1.1.343]
101783950  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101761612  glucose-6-phosphate 1-dehydrogenase, chloroplastic isoform X2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101767719  glucose-6-phosphate 1-dehydrogenase 4, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101771022  glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101778188  glucose-6-phosphate 1-dehydrogenase 2, chloroplastic [KO:K00036] [EC:1.1.1.49 1.1.1.363]
101776814  probable phospholipid hydroperoxide glutathione peroxidase 6, mitochondrial-like [KO:K00432] [EC:1.11.1.9]
101764634  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
101776343  phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic [KO:K00432] [EC:1.11.1.9]
101780768  probable phospholipid hydroperoxide glutathione peroxidase [KO:K00432] [EC:1.11.1.9]
101770687  probable glutathione peroxidase 4 [KO:K00432] [EC:1.11.1.9]
101786937  probable glutathione peroxidase 2 isoform X1 [KO:K00432] [EC:1.11.1.9]
101757638  1-Cys peroxiredoxin PER1 [KO:K11188] [EC:1.11.1.7 1.11.1.27 3.1.1.-]
101759806  ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
101771514  spermine synthase [KO:K00797] [EC:2.5.1.16]
101761225  spermine synthase isoform X2 [KO:K00797] [EC:2.5.1.16]
101781268  spermidine synthase 1 [KO:K00797] [EC:2.5.1.16]
101780973  probable L-ascorbate peroxidase 8, chloroplastic [KO:K00434] [EC:1.11.1.11]
101761338  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
101754668  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
101760004  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
101786781  probable L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
101769679  probable L-ascorbate peroxidase 7, chloroplastic [KO:K00434] [EC:1.11.1.11]
101753441  probable L-ascorbate peroxidase 4, peroxisomal [KO:K00434] [EC:1.11.1.11]
101776821  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
101770596  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101777285  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101769230  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101781737  ribonucleoside-diphosphate reductase small chain [KO:K10808] [EC:1.17.4.1]
101763742  ribonucleoside-diphosphate reductase small chain C [KO:K10808] [EC:1.17.4.1]
Compound
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00025  L-Glutamate
C00037  Glycine
C00051  Glutathione
C00072  Ascorbate
C00077  L-Ornithine
C00097  L-Cysteine
C00127  Glutathione disulfide
C00134  Putrescine
C00151  L-Amino acid
C00315  Spermidine
C00669  gamma-L-Glutamyl-L-cysteine
C00750  Spermine
C01322  RX
C01419  Cys-Gly
C01672  Cadaverine
C01879  5-Oxoproline
C02090  Trypanothione
C02320  R-S-Glutathione
C03170  Trypanothione disulfide
C03646  Bis-gamma-glutamylcystine
C03740  (5-L-Glutamyl)-L-amino acid
C05422  Dehydroascorbate
C05726  S-Substituted L-cysteine
C05727  S-Substituted N-acetyl-L-cysteine
C05729  R-S-Cysteinylglycine
C05730  Glutathionylspermidine
C16562  Glutathionylspermine
C16563  Bis(glutathionyl)spermine
C16564  Bis(glutathionyl)spermine disulfide
C16565  Aminopropylcadaverine
C16566  Glutathionylaminopropylcadaverine
C16567  Homotrypanothione
C16568  Homotrypanothione disulfide
C16663  Tryparedoxin
C16664  Tryparedoxin disulfide
Reference
  Authors
Josch C, Klotz LO, Sies H.
  Title
Identification of cytosolic leucyl aminopeptidase (EC 3.4.11.1) as the major cysteinylglycine-hydrolysing activity in rat liver.
  Journal
Biol Chem 384:213-8 (2003)
DOI:10.1515/BC.2003.023
Reference
  Authors
Chu L, Lai Y, Xu X, Eddy S, Yang S, Song L, Kolodrubetz D.
  Title
A 52-kDa leucyl aminopeptidase from treponema denticola is a cysteinylglycinase that mediates the second step of glutathione metabolism.
  Journal
J Biol Chem 283:19351-8 (2008)
DOI:10.1074/jbc.M801034200
Reference
  Authors
Cappiello M, Lazzarotti A, Buono F, Scaloni A, D'Ambrosio C, Amodeo P, Mendez BL, Pelosi P, Del Corso A, Mura U.
  Title
New role for leucyl aminopeptidase in glutathione turnover.
  Journal
Biochem J 378:35-44 (2004)
DOI:10.1042/BJ20031336
Reference
  Authors
Suzuki H, Kamatani S, Kim ES, Kumagai H.
  Title
Aminopeptidases A, B, and N and dipeptidase D are the four cysteinylglycinases of Escherichia coli K-12.
  Journal
J Bacteriol 183:1489-90 (2001)
DOI:10.1128/JB.183.4.1489-1490.2001
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
Reference
  Authors
Oza SL, Ariyanayagam MR, Fairlamb AH.
  Title
Characterization of recombinant glutathionylspermidine synthetase/amidase from Crithidia fasciculata.
  Journal
Biochem J 364:679-86 (2002)
DOI:10.1042/BJ20011370
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
Reference
  Authors
Ariyanayagam MR, Oza SL, Mehlert A, Fairlamb AH.
  Title
Bis(glutathionyl)spermine and other novel trypanothione analogues in Trypanosoma cruzi.
  Journal
J Biol Chem 278:27612-9 (2003)
DOI:10.1074/jbc.M302750200
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
Reference
  Authors
Comini M, Menge U, Wissing J, Flohe L.
  Title
Trypanothione synthesis in crithidia revisited.
  Journal
J Biol Chem 280:6850-60 (2005)
DOI:10.1074/jbc.M404486200
Reference
PMID:7813456
  Authors
Hunter KJ, Le Quesne SA, Fairlamb AH.
  Title
Identification and biosynthesis of N1,N9-bis(glutathionyl)aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi.
  Journal
Eur J Biochem 226:1019-27 (1994)
DOI:10.1111/j.1432-1033.1994.t01-1-01019.x
Reference
  Authors
Krauth-Siegel RL, Meiering SK, Schmidt H.
  Title
The parasite-specific trypanothione metabolism of trypanosoma and leishmania.
  Journal
Biol Chem 384:539-49 (2003)
DOI:10.1515/BC.2003.062
Reference
  Authors
Krauth-Siegel RL, Comini MA.
  Title
Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism.
  Journal
Biochim Biophys Acta 1780:1236-48 (2008)
DOI:10.1016/j.bbagen.2008.03.006
Reference
PMID:8892297
  Authors
Krauth-Siegel RL, Ludemann H.
  Title
Reduction of dehydroascorbate by trypanothione.
  Journal
Mol Biochem Parasitol 80:203-8 (1996)
DOI:10.1016/0166-6851(96)02689-8
Reference
  Authors
Dormeyer M, Reckenfelderbaumer N, Ludemann H, Krauth-Siegel RL.
  Title
Trypanothione-dependent synthesis of deoxyribonucleotides by Trypanosoma brucei ribonucleotide reductase.
  Journal
J Biol Chem 276:10602-6 (2001)
DOI:10.1074/jbc.M010352200
Reference
  Authors
Schmidt H, Krauth-Siegel RL.
  Title
Functional and physicochemical characterization of the thioredoxin system in Trypanosoma brucei.
  Journal
J Biol Chem 278:46329-36 (2003)
DOI:10.1074/jbc.M305338200
Reference
PMID:9851611
  Authors
Tetaud E, Fairlamb AH.
  Title
Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata.
  Journal
Mol Biochem Parasitol 96:111-23 (1998)
DOI:10.1016/S0166-6851(98)00120-0
Reference
  Authors
Castro H, Sousa C, Santos M, Cordeiro-da-Silva A, Flohe L, Tomas AM.
  Title
Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum.
  Journal
Free Radic Biol Med 33:1552-62 (2002)
DOI:10.1016/S0891-5849(02)01089-4
Reference
  Authors
Wilkinson SR, Temperton NJ, Mondragon A, Kelly JM.
  Title
Distinct mitochondrial and cytosolic enzymes mediate trypanothione-dependent peroxide metabolism in Trypanosoma cruzi.
  Journal
J Biol Chem 275:8220-5 (2000)
DOI:10.1074/jbc.275.11.8220
Reference
  Authors
Konig J, Fairlamb AH.
  Title
A comparative study of type I and type II tryparedoxin peroxidases in Leishmania major.
  Journal
FEBS J 274:5643-58 (2007)
DOI:10.1111/j.1742-4658.2007.06087.x
Reference
  Authors
Hillebrand H, Schmidt A, Krauth-Siegel RL.
  Title
A second class of peroxidases linked to the trypanothione metabolism.
  Journal
J Biol Chem 278:6809-15 (2003)
DOI:10.1074/jbc.M210392200
Reference
  Authors
Soksawatmaekhin W, Kuraishi A, Sakata K, Kashiwagi K, Igarashi K.
  Title
Excretion and uptake of cadaverine by CadB and its physiological functions in Escherichia coli.
  Journal
Mol Microbiol 51:1401-12 (2004)
DOI:10.1046/j.1365-2958.2003.03913.x
Reference
PMID:6798961
  Authors
Pegg AE, Shuttleworth K, Hibasami H.
  Title
Specificity of mammalian spermidine synthase and spermine synthase.
  Journal
Biochem J 197:315-20 (1981)
DOI:10.1042/bj1970315
Related
pathway
sita00220  Arginine biosynthesis
sita00250  Alanine, aspartate and glutamate metabolism
sita00270  Cysteine and methionine metabolism
sita00430  Taurine and hypotaurine metabolism
sita00460  Cyanoamino acid metabolism
KO pathway
ko00480   
LinkDB

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