Entry
Name
Thiamine metabolism - Schizosaccharomyces osmophilus (fission yeast)
Class
Metabolism; Metabolism of cofactors and vitamins
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Organism
Schizosaccharomyces osmophilus (fission yeast) [GN:
som ]
Gene
SOMG_02991 nmt1; 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Nmt1 [KO:K18278 ]
SOMG_03225 nfs1; mitochondrial [2Fe-2S] cluster assembly and tRNA modification cysteine desulfurase Nfs1 [KO:K04487 ] [EC:2.8.1.7 ]
Compound
C00118 D-Glyceraldehyde 3-phosphate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03373 Aminoimidazole ribotide
C04294 5-(2-Hydroxyethyl)-4-methylthiazole
C04327 4-Methyl-5-(2-phosphooxyethyl)thiazole
C04556 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
C04752 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
C11437 1-Deoxy-D-xylulose 5-phosphate
C15812 [Enzyme]-S-sulfanylcysteine
C15813 Adenylyl-[sulfur-carrier protein]
C15814 Thiocarboxy-[sulfur-carrier protein]
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20246 2-[(2R,5Z)-2-Carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate
C20247 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate
C20267 4-Amino-5-aminomethyl-2-methylpyrimidine
C20784 ADP-5-ethyl-4-methylthiazole-2-carboxylate
Reference
Authors
Kawasaki Y, Onozuka M, Mizote T, Nosaka K.
Title
Biosynthesis of hydroxymethylpyrimidine pyrophosphate in Saccharomyces cerevisiae.
Journal
Reference
Authors
Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP.
Title
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
Journal
Reference
Authors
Begley TP, Ealick SE, McLafferty FW
Title
Thiamin biosynthesis: still yielding fascinating biological chemistry.
Journal
Reference
Authors
Wightman R, Meacock PA
Title
The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine.
Journal
Reference
Authors
Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP
Title
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase.
Journal
Reference
Authors
Jurgenson CT, Begley TP, Ealick SE
Title
The structural and biochemical foundations of thiamin biosynthesis.
Journal
Related pathway
som00260 Glycine, serine and threonine metabolism
som00270 Cysteine and methionine metabolism
som00400 Phenylalanine, tyrosine and tryptophan biosynthesis
KO pathway
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