KEGG   PATHWAY: srho00260
Entry
srho00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Spirosoma rhododendri
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
srho00260  Glycine, serine and threonine metabolism
srho00260

Module
srho_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:srho00260]
srho_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:srho00260]
srho_M00621  Glycine cleavage system [PATH:srho00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Spirosoma rhododendri [GN:srho]
Gene
HH216_04495  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HH216_05890  aspartate kinase [KO:K00928] [EC:2.7.2.4]
HH216_10220  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
HH216_06385  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
HH216_09905  homoserine kinase [KO:K00872] [EC:2.7.1.39]
HH216_05570  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
HH216_20370  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
HH216_07810  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
HH216_09235  D-2-hydroxyacid dehydrogenase [KO:K00018] [EC:1.1.1.29]
HH216_00925  glycerate kinase [KO:K00865] [EC:2.7.1.165]
HH216_16650  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
HH216_01120  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
HH216_10455  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HH216_13375  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
HH216_10450  aminotransferase class V-fold PLP-dependent enzyme [KO:K00831] [EC:2.6.1.52]
HH216_15580  pyridoxal phosphate-dependent aminotransferase family protein [KO:K00639] [EC:2.3.1.29]
HH216_07340  flavin monoamine oxidase family protein [KO:K00274] [EC:1.4.3.4]
HH216_09790  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
HH216_08515  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
HH216_04520  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HH216_10720  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
HH216_02020  gcvH; glycine cleavage system protein GcvH [KO:K02437]
HH216_22840  pssA; CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
HH216_08175  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
HH216_05085  cystathionine gamma-synthase [KO:K01758] [EC:4.4.1.1]
HH216_13035  L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]
HH216_06020  ilvA; threonine ammonia-lyase [KO:K01754] [EC:4.3.1.19]
HH216_06860  amino acid racemase [KO:K25316] [EC:5.1.1.10]
HH216_05725  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
HH216_05730  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
srho00010  Glycolysis / Gluconeogenesis
srho00020  Citrate cycle (TCA cycle)
srho00230  Purine metabolism
srho00250  Alanine, aspartate and glutamate metabolism
srho00270  Cysteine and methionine metabolism
srho00290  Valine, leucine and isoleucine biosynthesis
srho00300  Lysine biosynthesis
srho00330  Arginine and proline metabolism
srho00460  Cyanoamino acid metabolism
srho00470  D-Amino acid metabolism
srho00564  Glycerophospholipid metabolism
srho00600  Sphingolipid metabolism
srho00620  Pyruvate metabolism
srho00630  Glyoxylate and dicarboxylate metabolism
srho00640  Propanoate metabolism
srho00680  Methane metabolism
srho00860  Porphyrin metabolism
srho00920  Sulfur metabolism
KO pathway
ko00260   
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