KEGG   PATHWAY: sutr00010
Entry
sutr00010                   Pathway                                
Name
Glycolysis / Gluconeogenesis - Suttonella sp. R2A3
Description
Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which sometimes contains operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003].
Class
Metabolism; Carbohydrate metabolism
Pathway map
sutr00010  Glycolysis / Gluconeogenesis
sutr00010

Module
sutr_M00002  Glycolysis, core module involving three-carbon compounds [PATH:sutr00010]
sutr_M00003  Gluconeogenesis, oxaloacetate => fructose-6P [PATH:sutr00010]
sutr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA [PATH:sutr00010]
Other DBs
GO: 0006096 0006094
Organism
Suttonella sp. R2A3 [GN:sutr]
Gene
L0B52_09490  glk; glucokinase [KO:K00845] [EC:2.7.1.2]
L0B52_09425  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
L0B52_06750  fbp; class 1 fructose-bisphosphatase [KO:K03841] [EC:3.1.3.11]
L0B52_02335  class I fructose-bisphosphate aldolase [KO:K11645] [EC:4.1.2.13]
L0B52_07215  tpiA; triose-phosphate isomerase [KO:K01803] [EC:5.3.1.1]
L0B52_03200  gap; type I glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
L0B52_03195  phosphoglycerate kinase [KO:K00927] [EC:2.7.2.3]
L0B52_08585  gpmA; 2,3-diphosphoglycerate-dependent phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
L0B52_03835  eno; phosphopyruvate hydratase [KO:K01689] [EC:4.2.1.11]
L0B52_06985  pyk; pyruvate kinase [KO:K00873] [EC:2.7.1.40]
L0B52_02530  ppsA; phosphoenolpyruvate synthase [KO:K01007] [EC:2.7.9.2]
L0B52_00740  aceE; pyruvate dehydrogenase (acetyl-transferring), homodimeric type [KO:K00163] [EC:1.2.4.1]
L0B52_00745  aceF; dihydrolipoyllysine-residue acetyltransferase [KO:K00627] [EC:2.3.1.12]
L0B52_03635  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
L0B52_03905  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
L0B52_01465  L-lactate dehydrogenase [KO:K00016] [EC:1.1.1.27]
L0B52_02085  aldehyde dehydrogenase family protein [KO:K00128] [EC:1.2.1.3]
L0B52_00165  acs; acetate--CoA ligase [KO:K01895] [EC:6.2.1.1]
L0B52_09430  alpha-D-glucose phosphate-specific phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
L0B52_01520  pckA; phosphoenolpyruvate carboxykinase (ATP) [KO:K01610] [EC:4.1.1.49]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00031  D-Glucose
C00033  Acetate
C00036  Oxaloacetate
C00068  Thiamin diphosphate
C00074  Phosphoenolpyruvate
C00084  Acetaldehyde
C00085  D-Fructose 6-phosphate
C00103  D-Glucose 1-phosphate
C00111  Glycerone phosphate
C00118  D-Glyceraldehyde 3-phosphate
C00186  (S)-Lactate
C00197  3-Phospho-D-glycerate
C00221  beta-D-Glucose
C00236  3-Phospho-D-glyceroyl phosphate
C00267  alpha-D-Glucose
C00354  D-Fructose 1,6-bisphosphate
C00469  Ethanol
C00631  2-Phospho-D-glycerate
C00668  alpha-D-Glucose 6-phosphate
C01159  2,3-Bisphospho-D-glycerate
C01172  beta-D-Glucose 6-phosphate
C01451  Salicin
C05125  2-(alpha-Hydroxyethyl)thiamine diphosphate
C06186  Arbutin
C06187  Arbutin 6-phosphate
C06188  Salicin 6-phosphate
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16255  [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
  Authors
Nishizuka Y (ed).
  Title
[Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1980)
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
  Authors
Michal G.
  Title
Biochemical Pathways
  Journal
Wiley (1999)
Related
pathway
sutr00020  Citrate cycle (TCA cycle)
sutr00030  Pentose phosphate pathway
sutr00500  Starch and sucrose metabolism
sutr00620  Pyruvate metabolism
sutr00640  Propanoate metabolism
sutr00710  Carbon fixation by Calvin cycle
KO pathway
ko00010   
LinkDB

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