PATHWAY: tua00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Triticum urartu (red wild einkorn wheat)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
tua_M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate [PATH:tua00020 ]
tua_M00011 Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate [PATH:tua00020 ]
Other DBs
Organism
Triticum urartu (red wild einkorn wheat) [GN:
tua ]
Gene
125550591 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
125550592 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
125550595 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
125535210 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like [KO:K00658 ] [EC:2.3.1.61 ]
125510763 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
125518009 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
125556048 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
125536824 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
125536828 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
125536831 succinate dehydrogenase subunit 3-2, mitochondrial-like [KO:K00236 ]
125545915 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
125515267 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
125509279 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
125511164 LOW QUALITY PROTEIN: dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
125530031 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
125513274 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
125530999 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
125518934 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
125523022 dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
125508390 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
tua00053 Ascorbate and aldarate metabolism
tua00250 Alanine, aspartate and glutamate metabolism
tua00280 Valine, leucine and isoleucine degradation
tua00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
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